دورية أكاديمية
أعرض في EDS

The Association Between Anemia of Chronic Inflammation and Alzheimer's Disease and Related Dementias.

التفاصيل البيبلوغرافية
العنوان: The Association Between Anemia of Chronic Inflammation and Alzheimer's Disease and Related Dementias.
المؤلفون: Andreev A; Brookdale University Hospital Medical Center, Department of Internal Medicine, Brooklyn, NY, USA.; Beth Israel Deaconess Medical Center, Department of Neurology, Boston, MA, USA., Erdinc B; Brookdale University Hospital Medical Center, Department of Internal Medicine, Brooklyn, NY, USA., Shivaraj K; Brookdale University Hospital Medical Center, Department of Internal Medicine, Brooklyn, NY, USA., Schmutz J; Ross University School of Medicine, Miramar, FL, USA., Levochkina O; Richmond University Medical Center, Department of Psychiatry, Staten Island, NY, USA., Bhowmik D; Brookdale University Hospital Medical Center, Department of Internal Medicine, Brooklyn, NY, USA., Farag F; Brookdale University Hospital Medical Center, Department of Internal Medicine, Brooklyn, NY, USA., Money KM; Beth Israel Deaconess Medical Center, Department of Neurology, Boston, MA, USA., Primavera LH; Touro College, School of Health Sciences, Bay Shore, NY, USA., Gotlieb V; Brookdale University Hospital Medical Center, Department of Internal Medicine, Division of Hematology & Oncology, Brooklyn, NY, USA., Sahni S; Brookdale University Hospital Medical Center, Department of Internal Medicine, Brooklyn, NY, USA.; Department of Primary Care, Touro College of Osteopathic Medicine, New York, NY, USA.; Department of Research Medicine, NYIT College of Osteopathic Medicine, Glen Head, NY, USA.
المصدر: Journal of Alzheimer's disease reports [J Alzheimers Dis Rep] 2020 Sep 18; Vol. 4 (1), pp. 379-391. Date of Electronic Publication: 2020 Sep 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: IOS Press Country of Publication: Netherlands NLM ID: 101705500 Publication Model: Electronic Cited Medium: Internet ISSN: 2542-4823 (Electronic) Linking ISSN: 25424823 NLM ISO Abbreviation: J Alzheimers Dis Rep Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam : IOS Press, [2017]-
مستخلص: Background: Dementia is a spectrum of neurological diseases characterized by memory impairment and cognitive decline with the pathogenesis and effective management remaining elusive. Several studies have identified a correlation between anemia and Alzheimer's disease and related dementias (ADRD); however, anemia subtypes and association with ADRD have yet to be studied conclusively.
Objective: To study an association between ADRD and anemia of chronic inflammation.
Methods: We conducted a retrospective case-control study of the patients, diagnosed with ADRD at Brookdale Hospital. Pair-wise comparisons between means of controls and cases in terms of iron studies and laboratory results were performed using a Mann-Whitney U test. Pair-wise comparisons between anemia subgroups (moderate and severe) were performed using a Two Sample proportion Z-Test, where for each couple of normally distributed population.
Results: There was a total of 4,517 (1,274 ADRD group; 3,243 Control group) patients. There was significant difference in hemoglobin 10.15 versus 11.04 [ p -value <0.001]. Iron studies showed a significant difference in ferritin 395±488.18 versus 263±1023.4 [ p  < 0.001], total iron binding capacity 225±84.08 versus 266±82.30 [ p  < 0.001] and serum iron level 64±39.34 versus 53±41.83 [ p  < 0.001]. Folic acid and vitamin B12 levels were normal in both groups. Severe and moderate anemia in the ADRD group were respectively 6.2% [95% CI: 4.2-8.4] and 13% [95% CI: 9.8-16.2] higher. Overall, incidence of moderate-to-severe anemia was found to be 19% higher in ADRD group [95% CI: 15.8-22.1].
Conclusion: We demonstrated an association between ADRD and anemia of chronic inflammation independent of age, renal function, and HgbA1C levels.
Competing Interests: The authors have no conflict of interest to report.
(© 2020 – IOS Press and the authors. All rights reserved.)
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فهرسة مساهمة: Keywords: Alzheimer’s disease; Alzheimer’s disease and related dementia; anemia; anemia of chronic inflammation; dementia
تواريخ الأحداث: Date Created: 20201109 Latest Revision: 20220418
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7592836
DOI: 10.3233/ADR-200178
PMID: 33163899
قاعدة البيانات: MEDLINE
الوصف
تدمد:2542-4823
DOI:10.3233/ADR-200178