دورية أكاديمية
[Research progress on potential targets-mitochondrial dynamics-related proteins in treatment of myocardial ischemia-reperfusion injury].
| العنوان: | [Research progress on potential targets-mitochondrial dynamics-related proteins in treatment of myocardial ischemia-reperfusion injury]. |
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| المؤلفون: | Man-Li Z; College of Traditional Chinese Medicine, Hunan University of Traditional Chinese Medicine Changsha 410208, China., Yu F; College of Traditional Chinese Medicine, Hunan University of Traditional Chinese Medicine Changsha 410208, China., Shu-le Q; College of Traditional Chinese Medicine, Hunan University of Traditional Chinese Medicine Changsha 410208, China., Xiao-Xin L; College of Traditional Chinese Medicine, Hunan University of Traditional Chinese Medicine Changsha 410208, China., Si-Qi XU; College of Traditional Chinese Medicine, Hunan University of Traditional Chinese Medicine Changsha 410208, China., Wei-Xiong J; College of Traditional Chinese Medicine, Hunan University of Traditional Chinese Medicine Changsha 410208, China National Key Discipline of Traditional Chinese Medicine Diagnostics, Hunan Provincial Key Laboratory,Hunan University of Chinese Medicine Changsha 410208, China. |
| المصدر: | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2020 Sep; Vol. 45 (17), pp. 4183-4195. |
| نوع المنشور: | Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Country of Publication: China NLM ID: 8913656 Publication Model: Print Cited Medium: Print ISSN: 1001-5302 (Print) Linking ISSN: 10015302 NLM ISO Abbreviation: Zhongguo Zhong Yao Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Beijing : Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Original Publication: [Beijing] : Zhongguo yao xue hui : [Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo, 1989- |
| مواضيع طبية MeSH: | Myocardial Infarction* , Myocardial Reperfusion Injury*/drug therapy , Percutaneous Coronary Intervention*, Humans ; Mitochondrial Dynamics ; Mitochondrial Proteins |
| مستخلص: | Acute myocardial infarction(AMI) is still the leading cause of death worldwide. At present, the treatment of AMI is mainly to restore the cardiac blood supply through myocardial reperfusion. With the widespread use of coronary artery bypass grafting and percutaneous coronary intervention(PCI), myocardial reperfusion injury is a major clinical problem. Mitochondrial dysfunction is an important pathological basis for myocardial ischemic injury. Therefore, mitochondria can be used as an important target against myocardial damage. In this article, we would briefly review the physiological functions of mitochondrial dynamics-related proteins as well as their pathological mechanisms and pharmacological interventions in treatment of myocardial ischemia-reperfusion injury. |
| فهرسة مساهمة: | Keywords: Ca~(2+); ROS; fission protein; fusion protein; mPTP; mitochondrial dynamics; mitophagy and apoptosis; pharmacological intervention |
| المشرفين على المادة: | 0 (Mitochondrial Proteins) |
| تواريخ الأحداث: | Date Created: 20201109 Date Completed: 20201110 Latest Revision: 20201110 |
| رمز التحديث: | 20231215 |
| DOI: | 10.19540/j.cnki.cjcmm.20200623.602 |
| PMID: | 33164403 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1001-5302 |
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| DOI: | 10.19540/j.cnki.cjcmm.20200623.602 |