دورية أكاديمية
[Systematic evaluation and Meta-analysis of efficacy and safety of Tianzhi Granules in treatment of vascular cognitive impairment].
| العنوان: | [Systematic evaluation and Meta-analysis of efficacy and safety of Tianzhi Granules in treatment of vascular cognitive impairment]. |
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| المؤلفون: | Wen-Yue HU; Beijing University of Chinese Medicine Beijing 100029, China., Zhen-Yun H; Beijing University of Chinese Medicine Beijing 100029, China., Hua-Ping MA; Beijing University of Chinese Medicine Beijing 100029, China., Jing-Feng L; Beijing University of Chinese Medicine Beijing 100029, China., Ze C; Beijing University of Chinese Medicine Beijing 100029, China. |
| المصدر: | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2020 Oct; Vol. 45 (19), pp. 4766-4775. |
| نوع المنشور: | Journal Article; Meta-Analysis |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Country of Publication: China NLM ID: 8913656 Publication Model: Print Cited Medium: Print ISSN: 1001-5302 (Print) Linking ISSN: 10015302 NLM ISO Abbreviation: Zhongguo Zhong Yao Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Beijing : Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Original Publication: [Beijing] : Zhongguo yao xue hui : [Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo, 1989- |
| مواضيع طبية MeSH: | Cognitive Dysfunction*/drug therapy , Drugs, Chinese Herbal*/adverse effects, Humans ; Treatment Outcome |
| مستخلص: | Tianzhi Granules has effects in calming liver wind, nourishing liver and kidney and activating blood. At present, it is used for treatment of vascular cognitive impairment. However, its efficacy and safety remained to be verified. Therefore, this study aims to systematically analyze the efficacy and safety of Tianzhi Granules in the treatment of vascular cognitive impairment. CNKI, VIP, WanFang, SinoMed, PubMed and Cochrane Library, ClinicalTrials.gov were retrieved to screen out relevant randomized controlled trials about the effect of Tianzhi Granules on vascular cognitive impairment according to the inclusion criteria. Two researchers independently used the risk of bias assessment tool for quality assessment, and extracted and checked the data. Cochrane systematic evaluation software RevMan 5.3 was used for data analysis. Twenty-seven articles involving 2 741 subjects were included. The intervention measure was Tianzhi Granules alone, and the control measure was Western medicine alone or blank control. According to the results, Tianzhi Granules was better than blank control and brain metabolism promoter in clinical efficacy rate and improvement of MMSE score. And it was better than blank control and nimodipine in the improvement of event-related potential(ERP) P300. Within 3 months, Tianzhi Granules had better effects than Western medicine group and blank group, with a low incidence of adverse events. Tianzhi Granules can be recommended for clinical use. However, due to the low quality of the include literatures, these potential benefits need to be confirmed in future standardized clinical trials with a large sample size. |
| فهرسة مساهمة: | Keywords: Meta-analysis; Tianzhi Granules; systematic review; vascular cognitive impairment |
| المشرفين على المادة: | 0 (Drugs, Chinese Herbal) |
| تواريخ الأحداث: | Date Created: 20201109 Date Completed: 20201110 Latest Revision: 20201110 |
| رمز التحديث: | 20221213 |
| DOI: | 10.19540/j.cnki.cjcmm.20200309.501 |
| PMID: | 33164444 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1001-5302 |
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| DOI: | 10.19540/j.cnki.cjcmm.20200309.501 |