دورية أكاديمية
أعرض في EDS

The role of IL-10 in immune responses against Pseudomonas aeruginosa during acute lung infection.

التفاصيل البيبلوغرافية
العنوان: The role of IL-10 in immune responses against Pseudomonas aeruginosa during acute lung infection.
المؤلفون: Belo VA; Departmento de Microbiologia E Imunologia, Universidade Federal de Alfenas, Alfenas, Brazil., Pereira JA; Departmento de Microbiologia E Imunologia, Universidade Federal de Alfenas, Alfenas, Brazil., Souza SFD; Departmento de Microbiologia E Imunologia, Universidade Federal de Alfenas, Alfenas, Brazil., Tana FL; Departmento de Microbiologia E Imunologia, Universidade Federal de Alfenas, Alfenas, Brazil., Pereira BP; Faculdade de Ciências Farmacêuticas, Universidade Federal de Alfenas, Alfenas, Brazil., Lopes DO; Laboratório de Biologia Molecular, Universidade Federal de São João Del-Rei (CCO), Divinópolis, Brazil., Ceron CS; Faculdade de Ciências Farmacêuticas, Universidade Federal de Alfenas, Alfenas, Brazil., Novaes RD; Departamento de Biologia Estrutural, Universidade Federal de Alfenas, Alfenas, Brazil., Corsetti PP; Laboratório de Imunologia das Doenças Infecciosas E Crônicas, Universidade José Do Rosário Vellano, Alfenas, Minas Gerais, Brazil., de Almeida LA; Departmento de Microbiologia E Imunologia, Universidade Federal de Alfenas, Alfenas, Brazil. leonardo.almeida@unifal-mg.edu.br.
المصدر: Cell and tissue research [Cell Tissue Res] 2021 Mar; Vol. 383 (3), pp. 1123-1133. Date of Electronic Publication: 2020 Nov 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417625 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0878 (Electronic) Linking ISSN: 0302766X NLM ISO Abbreviation: Cell Tissue Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin, New York, Springer-Verlag.
مواضيع طبية MeSH: Lung*/immunology , Lung*/pathology, Interleukin-10/*immunology , Pseudomonas Infections/*immunology , Pseudomonas aeruginosa/*immunology, Animals ; Immunity ; Matrix Metalloproteinase 9/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout
مستخلص: Pseudomonas aeruginosa is considered an opportunistic pathogen of great clinical importance. The clearance of this bacterium occurs through recognition of the pathogen by innate immune system receptors, leading to a lung inflammatory response. However, this response must be controlled via immunoregulatory pathways. In this study, we evaluate the role of endogenous murine IL-10 after acute infection with the virulent strain P. aeruginosa PA14. To assess the role of IL-10, intratracheal infection with the PA14 strain was performed in C57BL/6 or IL-10 KO mice. The PA14 strain was recovered in both types of animals, although IL-10 KO mice presented a higher number of viable bacteria in the lung when compared to the C57BL/6 group. Histopathological and stereological analyses showed that IL-10 KO mice had higher tissue damage and inflammatory infiltrate when compared to control animals. The activity of MMP-9 but not MMP-2, as well as IL-6 and TNF-α expression, were augmented in the lungs of infected animals and was much more evident in IL-10 KO animals when compared to the other analyzed groups. This work indicates that endogenous IL-10 control P. aeruginosa infection, the expression of pro-inflammatory genes, MMP-9 activity and histopathological processes of the infectious process in question.
References: Baddeley AJ, Gundersen HJ, Cruz-Orive LM (1986) Estimation of surface area from vertical sections. J Microsc 142:259–276. (PMID: 10.1111/j.1365-2818.1986.tb04282.x)
Chen W, Lian J, Ye J, Mo Q, Qin J, Hong G, Long-Wang C, Shao-Ce Z, Guang-Ju Z, Zhong-Qiu L (2017) Ethyl pyruvate reverses development of Pseudomonas aeruginosa pneumonia during sepsis-induced immunosuppression. Int Immunopharmacol 52:61–69. (PMID: 10.1016/j.intimp.2017.08.024)
Chmiel JF, Konstan MW, Knesebeck JE, Hilliard TL, Dawson DV, Berger M (1999) IL-10 attenuates excessive inflammation in chronic pseudomonas infection in mice. Am J Respir Crit Care Med 160:2040–2047. (PMID: 10.1164/ajrccm.160.6.9901043)
Chmiel JF, Konstan MW, Saadane A, Krenicky JE, Kirchner HL, Berger M (2002) Prolonged inflammatory response to acute pseudomonas challenge in interleukin-10 knockout mice. Am J Respir Crit Care Med 165:1176–1181. (PMID: 10.1164/ajrccm.165.8.2107051)
Corsetti PP, De Almeida LA, Carvalho NB, Azevedo V, Silva T, Teixeira HC, Faria AC, Oliveira S (2013) Enhances production of proinflammatory cytokines and leads to Brucella abortus clearance in mice. PLoS ONE 9:0074729. (PMID: 10.1371/journal.pone.0074729)
Guilbault C, Stotland P, Lachance C, Tam M, Keller A, Thompson-Snipes L, Cowley E, Hamilton T, Eidelman DH, Stevenson MM, Radiozioch D (2002) Influence of gender and interleukin-10 deficiency on the inflammatory response during lung infection with Pseudomonas aeruginosa in mice. Immunology 107:297–305. (PMID: 10.1046/j.1365-2567.2002.01508.x)
Kothari P, Pestana R, Mesraoua R, Elchaki R, Khan KM, Dannenberg AJ, Falcone D (2014) IL-6-mediated induction of matrix metalloproteinase-9 is modulated by JAK-dependent IL-10 expression in macrophages. J Immunology 192:349–357. (PMID: 10.4049/jimmunol.1301906)
Leech JM, Lacey KA, Mulcahy ME, Medina E, Mcloughlin RM (2017) IL-10 plays opposing roles during Staphylococcus aureus systemic and localized infections. J Immunol 198:2352–2365. (PMID: 10.4049/jimmunol.1601018)
Li WL, Wu CH, Yang J, Tang M, Chen LJ, Zhao SL (2015) Local inflammation alters MMP-2 and MMP-9 gelatinase expression associated with theseverity of nifedipine-induced gingival overgrowth: a rat model study. Inflammation. 38(4):1517-28. (PMID: 10.1007/s10753-015-0126-0)
Li Y, Chen L, Wang C, Chen J, Zhang X, Hu Y, Niu X, Pei D, He Z, Bi Y (2016) Extracellular matrix metalloproteinase inducer enhances host resistanceagainst Pseudomonas aeruginosa infection through MAPK signaling pathway. Am J Transl Res 8(12):5619-5627. (PMID: 280780325209512)
Lovewell RR, Patankar YR, Berwin B (2014) Mechanisms of phagocytosis and host clearance of Pseudomonas aeruginosa. Am J Physiol Lung Cell MoL Physiol 306:591–603. (PMID: 10.1152/ajplung.00335.2013)
Mandarim-de-Lacerda CA (2003) Stereological tools in biomedical research. An Acad Bras Cienc 75:469–486. (PMID: 10.1590/S0001-37652003000400006)
Mitzner W, Fallica J, Bishai J (2008) Anisotropic nature of mouse lung parenchyma. Ann Biomed Eng 36:2111–2120. (PMID: 10.1007/s10439-008-9538-4)
Moradali M, Ghods S, Rehm B (2017) Pseudomonas aeruginosa lifestyle: a paradigm for adaptation, survival, and persistence. Front Cell Infect Microbiol 7:39. (PMID: 10.3389/fcimb.2017.00039)
Novaes RD, Gonçalves RV, Cupertino MC, Marques DCS, Rosa DD, Peluzio MCG, Neves CA, Leite JPV (2012) Bark extract of Bathysa cuspidata attenuates extra-pulmonary acute lung injury induced by paraquat and reduces mortality in rats. Int J Exp Pathol 93:225–233. (PMID: 10.1111/j.1365-2613.2012.00808.x)
Novaes RD, Penitente AR, Talvani A, Natali AJ, Neves CA, Maldonado IR (2012) Use of fluorescence in a modified disector method to estimate the number of myocytes in cardiac tissue. Arq Bras Cardiol 98:252–258. (PMID: 10.1590/S0066-782X2012005000014)
Parks WC, Wilson CL, López-Boado Y (2004) Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat Rev Immunol 8:617–629. (PMID: 10.1038/nri1418)
Peñaloza HF, Schultz BM, Nieto PA, Salazar GA, Suazo I, Gonzalez PA et al (2016) Opposing roles of IL-10 in acute bacterial infection. Cytokine Growth Factor Rev 32:17–30. (PMID: 10.1016/j.cytogfr.2016.07.003)
Peñaloza HF, Noguera LP, Riedel CA, Bueno SM (2018) IL-10 plays opposing roles during Staphylococcus aureus systemic and localized infections. Frontiers in Microbiology 198:2352–2365.
Rocha Pereira AE, Rodrigues MÂ, Novaes RD, Caldas IS, Martins Souza RL, Costa Pereira AA (2017) Lipopolysaccharide-induced acute lung injury in mice chronically infected by Schistosoma mansoni. Exp Parasitol 178:21–29. (PMID: 10.1016/j.exppara.2017.05.004)
Rosa CP, Pereira JA, de Melo C, Santos N, Brancaglion GA, Silva EM, Tagliati CA, Novaes RD, Corsetti PP, de Almeida LA (2020) Vancomycin-induced gut dysbiosis during Pseudomonas aeruginosa pulmonary infection in a mice model. J Leukoc Biol 107(1):95–104. (PMID: 10.1002/JLB.4AB0919-432R)
Weibel ER (1989) Measuring through the microscope: development and evolution of stereological methods. J Microsc 155:393–403. (PMID: 10.1111/j.1365-2818.1989.tb02898.x)
Weibel ER, Hsia CC, Ochs M (2007) How much is there really? Why stereology is essential in lung morphometry. J Appl Physiol 102:459–467. (PMID: 10.1152/japplphysiol.00808.2006)
Wonnenberg B, Bischoff M, Beisswenger C, Dinh T, Bals R, Singh B, Tschering T (2016) The role of IL-1β in Pseudomonas aeruginosa in lung infection. Cell Tissue Res 364(2):225–229. (PMID: 10.1007/s00441-016-2387-9)
Zhang R, Ni HJ, Zhou HS (2017) Study on the expression of Toll-like receptor 4 and matrix metalloproteinase-9 in patients with chronic obstructive pulmonary disease and their clinical significance. Eur Rev Medical Pharmacol Sci 21(9):2185–2191.
Buff SM, Yu H, McCall JN, Caldwell SM, Ferkol TW, Flotte TR, Virella-Lowell IL (2010) IL-10 delivery by AAV5 vector attenuates inflammation in mice with Pseudomonas pneumonia. Gene Ther. 17(5):567‐576.
Christofi T, Apidianakis Y (2013) Drosophila immune priming against Pseudomonas aeruginosa short-lasting and depends on cellular and humoral immunity. F1000Research 1: 2–76.
Raoust E, Balloy V, Garcia-Verdugo I, Touqui L, Ramphal R, Chignard, M (2009) Pseudomonas aeruginosa LPS or flagellin are sufficient to activate TLR-dependent signaling in murine alveolar macrophages and airway epithelial cells. PLoS ONE.
فهرسة مساهمة: Keywords: Immunoregulation; Inflammatory response; Interleukin-10; Lung infection; MMP-9; P. aeruginosa
المشرفين على المادة: 0 (IL10 protein, mouse)
130068-27-8 (Interleukin-10)
EC 3.4.24.35 (Matrix Metalloproteinase 9)
EC 3.4.24.35 (Mmp9 protein, mouse)
تواريخ الأحداث: Date Created: 20201109 Date Completed: 20211001 Latest Revision: 20211001
رمز التحديث: 20221213
DOI: 10.1007/s00441-020-03308-4
PMID: 33165659
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-0878
DOI:10.1007/s00441-020-03308-4