دورية أكاديمية
Bone-Targeted Calcium Phosphate-Polymer Hybrid Nanoparticle Co-Deliver Zoledronate and Docetaxel to Treat Bone Metastasis of Prostate Cancer.
| العنوان: | Bone-Targeted Calcium Phosphate-Polymer Hybrid Nanoparticle Co-Deliver Zoledronate and Docetaxel to Treat Bone Metastasis of Prostate Cancer. |
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| المؤلفون: | Yang Q; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China; Department of Pharmacy, School of Medicine, Shaanxi Energy Institute, Xianyang 712000, China., Liu DZ; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China., Liu M; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China., Ji QF; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China., Mei QB; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China., Cheng Y; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China. Electronic address: chengying86128@126.com., Zhou SY; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China. Electronic address: zhousy@fmmu.edu.cn. |
| المصدر: | Journal of pharmaceutical sciences [J Pharm Sci] 2021 Feb; Vol. 110 (2), pp. 876-887. Date of Electronic Publication: 2020 Nov 07. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : New York, NY : Elsevier Original Publication: Easton, Pa., American Pharmaceutical Assn. |
| مواضيع طبية MeSH: | Antineoplastic Agents*/therapeutic use , Nanoparticles* , Prostatic Neoplasms*/drug therapy, Calcium Phosphates ; Cell Line, Tumor ; Docetaxel ; Humans ; Male ; Polymers ; Zoledronic Acid/therapeutic use |
| مستخلص: | Prostate cancer is the most common malignant tumor with bone metastasis, and there is still no ideal treatment for bone metastasis of prostate cancer. In this study, a pH and GSH dual sensitive calcium phosphate-polymer hybrid nanoparticle (DTX@Cap/HP) was prepared to co-deliver zoledronate (ZOL) and docetaxel (DTX) to treat bone metastasis of prostate cancer. DTX@Cap/HP exhibited high bone binding affinity and released more DTX and ZOL in acidic and high GSH concentration environment. A large amount of DTX@Cap/HP was uptaken by PC-3 cell in acidic medium than that in neutral medium. DTX@Cap/HP obviously reduced PC-3 cell proliferation and bone lesion in in-vitro 3D model of bone metastases of prostate cancer. Besides, DTX@Cap/HP also exhibited stronger anti bone metastases of prostate cancer activity in vivo as compared with the same dose of DTX + ZOL, which resulted from the co-delivery of DTX and ZOL to bone metastases of prostate cancer by DTX@Cap/HP and the synergistic effects of DTX and ZOL. DTX@Cap/HP has great potential in the treatment of bone metastases of prostate cancer. (Copyright © 2020 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.) |
| التعليقات: | Erratum in: J Pharm Sci. 2024 Jan 28;:. (PMID: 38290614) |
| فهرسة مساهمة: | Keywords: Bone lesion; Bone metastasis of prostate cancer; Docetaxel; Zoledronate |
| المشرفين على المادة: | 0 (Antineoplastic Agents) 0 (Calcium Phosphates) 0 (Polymers) 15H5577CQD (Docetaxel) 6XC1PAD3KF (Zoledronic Acid) |
| تواريخ الأحداث: | Date Created: 20201109 Date Completed: 20210617 Latest Revision: 20240201 |
| رمز التحديث: | 20240201 |
| DOI: | 10.1016/j.xphs.2020.11.005 |
| PMID: | 33166581 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1520-6017 |
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| DOI: | 10.1016/j.xphs.2020.11.005 |