دورية أكاديمية
Dorsal hippocampus plays a causal role in context-induced reinstatement of alcohol-seeking in rats.
| العنوان: | Dorsal hippocampus plays a causal role in context-induced reinstatement of alcohol-seeking in rats. |
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| المؤلفون: | Felipe JM; Department of Pharmacology, Universidade Federal de São Paulo - UNIFESP, São Paulo, SP 04023-062, Brazil. Electronic address: jackfelipe.jm@gmail.com., Palombo P; Department of Pharmacology, Universidade Federal de São Paulo - UNIFESP, São Paulo, SP 04023-062, Brazil. Electronic address: pa_palombo@hotmail.com., Bianchi PC; Department of Pharmacology, Universidade Federal de São Paulo - UNIFESP, São Paulo, SP 04023-062, Brazil. Electronic address: paula.cbianchi@gmail.com., Zaniboni CR; Department of Pharmacology, Universidade Federal de São Paulo - UNIFESP, São Paulo, SP 04023-062, Brazil. Electronic address: carolrzaniboni@gmail.com., Anésio A; Department of Pharmacology, Universidade Federal de São Paulo - UNIFESP, São Paulo, SP 04023-062, Brazil. Electronic address: augusto.sca@hotmail.com., Yokoyama TS; Department of Pharmacology, Universidade Federal de São Paulo - UNIFESP, São Paulo, SP 04023-062, Brazil. Electronic address: thais_yokoyama@hotmail.com., Engi SA; Department of Pharmacology, Universidade Federal de São Paulo - UNIFESP, São Paulo, SP 04023-062, Brazil. Electronic address: she12097@hotmail.com., Carneiro-de-Oliveira PE; Psychology Laboratory, Psychology Department, Universidade Federal de São Carlos - UFSCar, São Carlos, SP, 13565-905, Brazil. Electronic address: paulo_eco5@yahoo.com.br., Planeta CDS; Laboratory of Pharmacology, São Paulo State University (Unesp), School of Pharmaceutical Sciences, Araraquara, SP, Brazil. Electronic address: cplaneta@fcfar.unesp.br., Leão RM; Biomedical Sciences Institute, Universidade Federal de Uberlândia - UFU Uberlândia, MG 38400-902, Brazil. Electronic address: rodrigomolini@yahoo.com.br., Cruz FC; Department of Pharmacology, Universidade Federal de São Paulo - UNIFESP, São Paulo, SP 04023-062, Brazil. Electronic address: ccruzfabio@yahoo.com.br. |
| المصدر: | Behavioural brain research [Behav Brain Res] 2021 Feb 01; Vol. 398, pp. 112978. Date of Electronic Publication: 2020 Oct 24. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8004872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7549 (Electronic) Linking ISSN: 01664328 NLM ISO Abbreviation: Behav Brain Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Reinforcement, Psychology*, Alcoholism/*physiopathology , Hippocampus/*physiology, Animals ; Behavior, Animal/physiology ; Cobalt/pharmacology ; Disease Models, Animal ; Extinction, Psychological/physiology ; Hippocampus/drug effects ; Male ; Rats ; Rats, Long-Evans |
| مستخلص: | Drug addiction is a chronic mental disorder characterized by frequent relapses. Contextual cues associated with drug use to play a critical causal role in drug-seeking behavior. The hippocampus has been implicated in encoding drug associative memories. Here we examine whether the dorsal hippocampus mediates context-induced reinstatement of alcohol-seeking. Male Long-Evans rats were trained to self-administer alcohol in Context A. Alcohol self-administration was extinguished in a distinct context (Context B). On the test day, animals were re-exposed to the alcohol Context A or the extinction Context B. Next, to assess a causal role for the dorsal hippocampus in context-induced alcohol-seeking, on the test day, we injected cobalt chloride (CoCl2; a nonselective synapse inhibitor) or vehicle into the dorsal hippocampus, and 15 min later, rats were tested by re-exposing them to the drug-associated context. The re-exposure to the alcohol-associated Context A reinstated alcohol seeking and increased Fos-positive cells in the dorsal hippocampus neurons (CA1, CA3, and Dentate Gyrus). Pharmacological inactivation with cobalt chloride of the dorsal hippocampus attenuated the reinstatement of alcohol-seeking. Our data suggest that the dorsal hippocampus may be involved in context-induced alcohol-seeking behavior. (Copyright © 2020 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Alcohol self-administration; Drug environment; Extinction; Reinstatement |
| المشرفين على المادة: | 3G0H8C9362 (Cobalt) EVS87XF13W (cobaltous chloride) |
| تواريخ الأحداث: | Date Created: 20201110 Date Completed: 20211115 Latest Revision: 20211115 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.bbr.2020.112978 |
| PMID: | 33169700 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7549 |
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| DOI: | 10.1016/j.bbr.2020.112978 |