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Prevalence and Risk Factors of Human Leishmaniasis in Ethiopia: A Systematic Review and Meta-Analysis.

التفاصيل البيبلوغرافية
العنوان: Prevalence and Risk Factors of Human Leishmaniasis in Ethiopia: A Systematic Review and Meta-Analysis.
المؤلفون: Haftom M; Department of Nursing, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. haftommekonnen@gmail.com., Petrucka P; College of Nursing, University of Saskatchewan, Saskatchewan, Canada., Gemechu K; Department of Nursing, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia., Nesro J; Department of Midwifery, College of Medicine and Health Science, Jima University, Jima, Ethiopia., Amare E; Department of Public Health, College of Health Sciences, Adigrat University, Adigrat, Ethiopia., Hailu T; Department of Nursing, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia., Ashebir Y; Department of Nursing, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia., Gebreheat G; Department of Nursing, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia., Hagos H; Department of Nursing, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia., Gebremedhin D; Department of Nursing, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia., Gebremariam A; Department of Public Health, College of Health Sciences, Adigrat University, Adigrat, Ethiopia.
المصدر: Infectious diseases and therapy [Infect Dis Ther] 2021 Mar; Vol. 10 (1), pp. 47-60. Date of Electronic Publication: 2020 Nov 10.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Adis Country of Publication: New Zealand NLM ID: 101634499 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2193-8229 (Print) Linking ISSN: 21936382 NLM ISO Abbreviation: Infect Dis Ther Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2014- : [Auckland] Adis
Original Publication: [London] : Springer Healthcare
مستخلص: Introduction: Tropical diseases are public health problems affecting hundreds of millions of people globally. However, the development of adequate, affordable, and accessible treatments is mostly neglected, resulting in significant morbidity and mortality that could otherwise be averted. Leishmaniasis is one of the neglected tropical diseases caused by the obligate intracellular protozoan Leishmania parasite and transmitted by the bite of infected phlebotomine sandflies. No systematic review and meta-analysis has been done to identify the prevalence and risk factors of leishmaniasis to the authors' knowledge. Therefore, the objective was to determine the prevalence and risk factors of human leishmaniasis in Ethiopia.
Methods: Eleven studies conducted in all regions of Ethiopia, which were fully accessible, written in any language, and original articles done on prevalence and risk factors of leishmaniasis, were included. STATA™ version 11.1 was used for statistical analysis. Chi-square, I 2 , and p values were assessed to check heterogeneity. A random effects model with heterogeneity taken from an inverse-variance model was employed to estimate the pooled effect. Subgroup meta-analysis was computed to reduce random variations among each article's point prevalence, and Egger and funnel plots were used to check for publication bias.
Results: The highest proportion of human leishmaniasis was reported from a study done in Amhara region (39.1%), and the lowest was reported from a survey done in Tigray (2.3%). The overall pooled prevalence of leishmaniasis was 9.13% (95% CI 5-13.27). Subgroup analysis by region revealed moderate heterogeneity (I 2  = 51.8%) in studies conducted in the Southern Nations Nationalities and Peoples Region (SNNPR). The presence of hyraxes and being male were associated with an increased risk of human leishmaniasis.
Conclusion: The prevalence of leishmaniasis in Ethiopia remains high (9.13%), with significant risk factors being male and the presence of hyraxes within a 300-m radius of the sleeping area.
References: Alvar J, Vélez ID, Bern C, et al. Leishmaniasis worldwide and global estimates of its incidence. PloS One. 2012;7(5):e35671.
Bailey F, Mondragon-Shem K, Hotez P, et al. A new perspective on cutaneous leishmaniasis—implications for global prevalence and burden of disease estimates. PLoS Negl Trop Dis. 2017;11(8):e0005739. (PMID: 10.1371/journal.pntd.0005739)
Deribe K, Meribo K, Gebre T, et al. The burden of neglected tropical diseases in Ethiopia, and opportunities for integrated control and elimination. Parasit Vectors. 2012;5(1):240. (PMID: 10.1186/1756-3305-5-240)
Palatnik-de-Sousa CB, Day MJ. One Health: the global challenge of epidemic and endemic leishmaniasis. Parasit Vectors. 2011;4(1):1–10. (PMID: 10.1186/1756-3305-4-197)
Esch KJ, Petersen CA. Transmission and epidemiology of zoonotic protozoal diseases of companion animals. Clin Microbiol Rev. 2013;26(1):58–85. (PMID: 10.1128/CMR.00067-12)
Assefa A. Leishmaniasis in Ethiopia: a systematic review and meta-analysis of prevalence in animals and humans. Heliyon. 2018;4(8):e00723. (PMID: 10.1016/j.heliyon.2018.e00723)
Deribew A, Kebede B, Tessema GA, et al. Mortality and disability-adjusted life-years (dalys) for common neglected tropical diseases in Ethiopia, 1990–2015: evidence from the global burden of disease study 2015. Ethiop Med J. 2017;55(1):3. (PMID: 291486335582634)
Chappuis F, Sundar S, Hailu A, et al. Visceral leishmaniasis: what are the needs for diagnosis, treatment and control? Nat Rev Microbiol. 2007;5(11):873–82. (PMID: 10.1038/nrmicro1748)
Murray HW, Berman JD, Davies CR, Saravia NG. Advances in leishmaniasis. Lancet. 2005;366(9496):1561–77. (PMID: 10.1016/S0140-6736(05)67629-5)
Kühne V, Rezaei Z, Pitzinger P, Büscher P. Systematic review on antigens for serodiagnosis of visceral leishmaniasis, with a focus on East Africa. PLoS Negl Trop Dis. 2019;13(8):e0007658. (PMID: 10.1371/journal.pntd.0007658)
Den Boer M, Argaw D, Jannin J, Alvar J. Leishmaniasis impact and treatment access. Clin Microbiol Infect. 2011;17(10):1471–7. (PMID: 10.1111/j.1469-0691.2011.03635.x)
Hotez PJ, Molyneux DH, Fenwick A, et al. Control of neglected tropical diseases. N Engl J Med. 2007;357(10):1018–27. (PMID: 10.1056/NEJMra064142)
Tsegaw T, Gadisa E, Seid A, et al. Identification of environmental parameters and risk mapping of visceral leishmaniasis in Ethiopia by using geographical information systems and a statistical approach. Geospatial Health. 2013;7(2):299–308. (PMID: 10.4081/gh.2013.88)
Hailu A, Gramiccia M, Kager P. Visceral leishmaniasis in Aba-Roba, south-western Ethiopia: prevalence and incidence of active and subclinical infections. Ann Trop Med Parasitol. 2009;103(8):659–70. (PMID: 10.1179/000349809X12554106963555)
Khalil E, Zijlstra EE, Kager PA, El Hassan AM. Epidemiology and clinical manifestations of Leishmania donovani infection in two villages in an endemic area in eastern Sudan. Trop Med Int Health. 2002;7(1):35–44. (PMID: 10.1046/j.1365-3156.2002.00832.x)
Renslo AR, McKerrow JH. Drug discovery and development for neglected parasitic diseases. Nat Chem Biol. 2006;2(12):701. (PMID: 10.1038/nchembio837)
Trouiller P, Olliaro P, Torreele E, Orbinski J, Laing R, Ford N. Drug development for neglected diseases: a deficient market and a public-health policy failure. Lancet. 2002;359(9324):2188–94. (PMID: 10.1016/S0140-6736(02)09096-7)
Gadisa E, Tsegaw T, Abera A, et al. Eco-epidemiology of visceral leishmaniasis in Ethiopia. Parasit Vectors. 2015;8(1):381. (PMID: 10.1186/s13071-015-0987-y)
Pires M, Wright B, Kaye PM, et al. The impact of leishmaniasis on mental health and psychosocial well-being: a systematic review. PLoS One. 2019;14(10):e0223313.
Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264–9. (PMID: 10.7326/0003-4819-151-4-200908180-00135)
Modesti PA, Reboldi G, Cappuccio FP, et al. Panethnic differences in blood pressure in Europe: a systematic review and meta-analysis. PLoS One. 2016;11(1):e0147601. (PMID: 10.1371/journal.pone.0147601)
Ali A, Ashford R. Visceral leishmaniasis in Ethiopia. I. Cross-sectional leishmanin skin test in an endemic locality. Ann Trop Med Parasitol. 1993;87(2):157–61. (PMID: 10.1080/00034983.1993.11812749)
Wondimeneh Y, Takele Y, Atnafu A, Ferede G, Muluye D. Trend analysis of visceral leishmaniasis at Addis Zemen health center, Northwest Ethiopia. BioMed Res Int. 2014;2014:2014:545393. https://doi.org/10.1155/2014/545393 .
Yohannes M, Abebe Z, Boelee E. Prevalence and environmental determinants of cutaneous leishmaniasis in rural communities in Tigray, northern Ethiopia. PLoS Negl Trop Dis. 2019;13(9):e0007722. (PMID: 10.1371/journal.pntd.0007722)
Abera A, Tasew G, Tsegaw T, et al. Visceral leishmaniasis in Benishangul-Gumuz regional state, Western Ethiopia: reemerging or emerging? Am J Trop Med Hygiene. 2016;95(1):104–8. (PMID: 10.4269/ajtmh.15-0738)
Alebie G, Worku A, Yohannes S, Urga B, Hailu A, Tadesse D. Epidemiology of visceral leishmaniasis in Shebelle Zone of Somali Region, eastern Ethiopia. Parasit Vectors. 2019;12(1):209. (PMID: 10.1186/s13071-019-3452-5)
Ayehu A, Aschale Y, Lemma W, et al. Seroprevalence of asymptomatic leishmania donovani among laborers and associated risk factors in agricultural camps of West Armachiho District, Northwest Ethiopia: a cross-sectional study. J Parasitol Res. 20182018:5751743. https://doi.org/10.1155/2018/5751743.
Bekele F, Belay T, Zeynudin A, Hailu A. Visceral leishmaniasis in selected communities of Hamar and Banna-Tsamai districts in Lower Omo Valley, South West Ethiopia: Sero-epidemological and Leishmanin Skin Test Surveys. PloS One. 2018;13(5):e0197430. https://doi.org/10.1371/journal.pone.0197430.
Bsrat A, Berhe M, Gadissa E, et al. Serological investigation of visceral Leishmania infection in human and its associated risk factors in Welkait District, Western Tigray, Ethiopia. Parasite Epidemiol Control. 2018;3(1):13–20. (PMID: 10.1016/j.parepi.2017.10.004)
Bsrat A, Berhe N, Balkew M, et al. Epidemiological study of cutaneous leishmaniasis in Saesie Tsaeda-emba district, eastern Tigray, northern Ethiopia. Parasit Vectors. 2015;8(1):149. (PMID: 10.1186/s13071-015-0758-9)
Negera E, Gadisa E, Yamuah L, et al. Outbreak of cutaneous leishmaniasis in Silti woreda, Ethiopia: risk factor assessment and causative agent identification. Trans R Soc Trop Med Hyg. 2008;102(9):883–90. (PMID: 10.1016/j.trstmh.2008.03.021)
Gebremichael TD, Bariagabr FH, Abreha HH. Incidence and trends of leishmaniasis and its risk factors in Humera, Western Tigray. J Parasitol Res. 2018;2018:8463097.
Argaw D, Mulugeta A, Herrero M, et al. Risk factors for visceral leishmaniasis among residents and migrants in Kafta-Humera, Ethiopia. PLoS Negl Trop Dis. 2013;7(11):e2543.
Hotez PJ, Kamath A. Neglected tropical diseases in sub-Saharan Africa: review of their prevalence, distribution, and disease burden. PLoS Negl Trop Dis. 2009;3(8):e412.
van Griensven J, Gadisa E, Aseffa A, Hailu A, Beshah AB, Diro E. Treatment of cutaneous leishmaniasis caused by Leishmania aethiopica: a systematic review. PLoS Negl Trop Dis. 2016;10(3):e0004495.
Nackers F, Mueller YK, Salih N, et al. Determinants of visceral leishmaniasis: a case-control study in Gedaref State, Sudan. PLoS Negl Trop Dis. 2015;9(11):e0004187.
van Henten S, Adriaensen W, Fikre H, et al. Cutaneous leishmaniasis due to leishmania aethiopica. EClinicalMedicine. 2018;6:69–81. (PMID: 10.1016/j.eclinm.2018.12.009)
Yared S, Deribe K, Gebreselassie A, et al. Risk factors of visceral leishmaniasis: a case control study in north-western Ethiopia. Parasit Vectors. 2014;7(1):470. (PMID: 10.1186/s13071-014-0470-1)
فهرسة مساهمة: Keywords: Ethiopia; Infectious disease; Leishmaniasis; Neglected tropical diseases; Prevalence
تواريخ الأحداث: Date Created: 20201110 Latest Revision: 20210315
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7652913
DOI: 10.1007/s40121-020-00361-y
PMID: 33170497
قاعدة البيانات: MEDLINE
الوصف
تدمد:2193-8229
DOI:10.1007/s40121-020-00361-y