دورية أكاديمية
Rh(III)-Catalyzed Imidoyl C-H Carbamylation and Cyclization to Bicyclic [1,3,5]Triazinones.
| العنوان: | Rh(III)-Catalyzed Imidoyl C-H Carbamylation and Cyclization to Bicyclic [1,3,5]Triazinones. |
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| المؤلفون: | Confair DN; Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States., Greenwood NS; Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States., Mercado BQ; Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States., Ellman JA; Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States. |
| المصدر: | Organic letters [Org Lett] 2020 Nov 20; Vol. 22 (22), pp. 8993-8997. Date of Electronic Publication: 2020 Nov 10. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : American Chemical Society, c1999- |
| مواضيع طبية MeSH: | Imines/*chemistry , Rhodium/*chemistry , Triazines/*chemistry, Catalysis ; Cyclization ; Molecular Structure ; Protein Carbamylation |
| مستخلص: | A Rh(III)-catalyzed synthesis of bicyclic [1,3,5]triazinones from a diverse array of imines coupled with ethyl (pivaloyloxy)carbamate is reported. The preparation of [5,6]- and [6,6]-bicyclic heterocycles substituted with aryl, alkyl, and alkoxy groups demonstrated a broad reaction scope. The efficiency of this approach was further enhanced with the development of a three-component variant featuring in situ imine formation. X-ray crystallographic characterization of a rhodacycle formed by imidoyl C-H activation provides support for the proposed mechanism. |
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| معلومات مُعتمدة: | R35 GM122473 United States GM NIGMS NIH HHS |
| المشرفين على المادة: | 0 (Imines) 0 (Triazines) DMK383DSAC (Rhodium) |
| تواريخ الأحداث: | Date Created: 20201111 Date Completed: 20210810 Latest Revision: 20211121 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7702018 |
| DOI: | 10.1021/acs.orglett.0c03393 |
| PMID: | 33172274 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1523-7052 |
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| DOI: | 10.1021/acs.orglett.0c03393 |