دورية أكاديمية
أعرض في EDS

Childhood bronchiolitis obliterans in Hong Kong-case series over a 20-year period.

التفاصيل البيبلوغرافية
العنوان: Childhood bronchiolitis obliterans in Hong Kong-case series over a 20-year period.
المؤلفون: Chan KC; Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Sha Tin, Hong Kong., Yu MW; Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Sha Tin, Hong Kong., Cheung TWY; Department of Paediatrics and Adolescent Medicine, Tuen Mun Hospital, Tuen Mun, Hong Kong., Lam DSY; Department of Paediatrics and Adolescent Medicine, Tuen Mun Hospital, Tuen Mun, Hong Kong., Leung TNH; Department of Paediatrics and Adolescent Medicine, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong., Tsui TK; Department of Paediatrics and Adolescent Medicine, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong., Ip KI; Department of Paediatrics and Adolescent Medicine, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong., Chau CSK; Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Pok Fu Lam, Hong Kong., Lee SL; Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Pok Fu Lam, Hong Kong., Yip AYF; Department of Paediatrics, Kwong Wah Hospital, Yau Ma Tei, Hong Kong., Wong TW; Department of Paediatrics and Adolescent Medicine, Alice Ho Miu Ling Nethersole Hospital, Tai Po, Hong Kong., Mak VCW; Department of Paediatrics and Adolescent Medicine, Alice Ho Miu Ling Nethersole Hospital, Tai Po, Hong Kong., Li AM; Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Sha Tin, Hong Kong.
المصدر: Pediatric pulmonology [Pediatr Pulmonol] 2021 Jan; Vol. 56 (1), pp. 153-161. Date of Electronic Publication: 2020 Nov 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8510590 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-0496 (Electronic) Linking ISSN: 10990496 NLM ISO Abbreviation: Pediatr Pulmonol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2005-> : Hoboken, NJ : Wiley-Liss
Original Publication: [Philadelphia, PA] : W.B. Saunders, [c1985-
مواضيع طبية MeSH: Bronchiolitis Obliterans/*epidemiology, Adenoviridae Infections ; Adolescent ; Bronchiolitis Obliterans/physiopathology ; Child ; Child, Preschool ; Disease Progression ; Female ; Hong Kong/epidemiology ; Humans ; Infant ; Male ; Retrospective Studies ; Risk Factors
مستخلص: Background and Objective: Bronchiolitis obliterans (BO) is a rare but serious condition. The natural history and outcomes remain poorly understood. In this clinical review, we aimed to describe the clinical characteristics and outcomes of children diagnosed with BO in Hong Kong (HK).
Methods: This was a retrospective study of pediatric patients with BO under the care of six respiratory units in HK from January 1996 to December 2015. Information was retrieved from medical records.
Results: Fifty-six patients were included with a male predominance (67.9%). The median age at diagnosis was 1.98 years (interquartile range [IQR]: 0.84-4.99 years). Postinfectious BO (PIBO) was the commonest cause (64.3%) followed by posthematopoietic stem-cell transplant (21.4%). Adenovirus (63.2%) was the commonest causative pathogen among PIBO. The median follow-up duration was 9.7 years (IQR: 2.9-14.3 years). Twenty-five patients (44.6%) could achieve symptom-free recovery at the time of follow-up. Five (8.9%) and three (5.4%) were oxygen or ventilator dependent, respectively. There were two deaths, both had posttransplant BO. Patients who developed BO after transplant had significantly worse lung function than those with PIBO. There were no risk factors significantly associated with worse clinical outcomes (oxygen/ventilator dependence or death) by logistic regression. Among patients with PIBO, coinfection at presentation was significantly associated with persistent symptoms at follow-up (p = .028).
Conclusions: The most common cause of childhood BO in HK is postinfectious and coinfection at presentation was associated with persistent symptoms at follow-up. Further studies are needed to better elucidate disease progression, treatment options and long term outcomes.
(© 2020 Wiley Periodicals LLC.)
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فهرسة مساهمة: Keywords: bronchiolitis obliterans; children; lung GvHD; postinfection
تواريخ الأحداث: Date Created: 20201111 Date Completed: 20210609 Latest Revision: 20210609
رمز التحديث: 20240628
DOI: 10.1002/ppul.25166
PMID: 33174693
قاعدة البيانات: MEDLINE
الوصف
تدمد:1099-0496
DOI:10.1002/ppul.25166