دورية أكاديمية
أعرض في EDS

Low SARS-CoV-2 seroprevalence in blood donors in the early COVID-19 epidemic in the Netherlands.

التفاصيل البيبلوغرافية
العنوان: Low SARS-CoV-2 seroprevalence in blood donors in the early COVID-19 epidemic in the Netherlands.
المؤلفون: Slot E; Department of Blood-borne Infections, Sanquin Research, Amsterdam, The Netherlands. e.slot@sanquin.nl.; Department of Medical Affairs, Sanquin Corporate Staff, Amsterdam, The Netherlands. e.slot@sanquin.nl., Hogema BM; Department of Blood-borne Infections, Sanquin Research, Amsterdam, The Netherlands.; Department of Virology, Sanquin Diagnostic Services, Amsterdam, The Netherlands., Reusken CBEM; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.; Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands., Reimerink JH; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Molier M; Department of Blood-borne Infections, Sanquin Research, Amsterdam, The Netherlands., Karregat JHM; Department of Donor Studies, Sanquin Research, Amsterdam, The Netherlands., IJlst J; National Screening Laboratory, Sanquin Laboratory Services, Amsterdam, The Netherlands., Novotný VMJ; Department of Medical Affairs, Sanquin Blood Bank, Amsterdam, The Netherlands., van Lier RAW; Landsteiner Laboratory, Sanquin Research, Amsterdam, The Netherlands.; Department of Experimental Immunology, University of Amsterdam, Amsterdam, The Netherlands., Zaaijer HL; Department of Blood-borne Infections, Sanquin Research, Amsterdam, The Netherlands. h.zaaijer@sanquin.nl.; Department of Virology, Sanquin Diagnostic Services, Amsterdam, The Netherlands. h.zaaijer@sanquin.nl.; Department of Medical Microbiology, Amsterdam UMC, Amsterdam, The Netherlands. h.zaaijer@sanquin.nl.
المصدر: Nature communications [Nat Commun] 2020 Nov 12; Vol. 11 (1), pp. 5744. Date of Electronic Publication: 2020 Nov 12.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Antibodies, Viral/*blood , Blood Donors/*statistics & numerical data , Coronavirus Infections/*epidemiology , Pneumonia, Viral/*epidemiology, Adolescent ; Adult ; Aged ; Asymptomatic Diseases/epidemiology ; Betacoronavirus/isolation & purification ; COVID-19 ; Humans ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Middle Aged ; Netherlands ; Pandemics ; Prevalence ; SARS-CoV-2 ; Seroepidemiologic Studies ; Social Isolation ; Young Adult
مستخلص: The world is combating an ongoing COVID-19 pandemic with health-care systems, society and economies impacted in an unprecedented way. It is unclear how many people have contracted the causative coronavirus (SARS-CoV-2) unknowingly and are asymptomatic. Therefore, reported COVID-19 cases do not reflect the true scale of outbreak. Here we present the prevalence and distribution of antibodies to SARS-CoV-2 in a healthy adult population of the Netherlands, which is a highly affected country, using a high-performance immunoassay. Our results indicate that one month into the outbreak (i) the seroprevalence in the Netherlands was 2.7% with substantial regional variation, (ii) the hardest-hit areas showed a seroprevalence of up to 9.5%, (iii) the seroprevalence was sex-independent throughout age groups (18-72 years), and (iv) antibodies were significantly more often present in younger people (18-30 years). Our study provides vital information on the extent of exposure to SARS-CoV-2 in a country where social distancing is in place.
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المشرفين على المادة: 0 (Antibodies, Viral)
0 (Immunoglobulin G)
0 (Immunoglobulin M)
تواريخ الأحداث: Date Created: 20201113 Date Completed: 20201124 Latest Revision: 20231112
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7665189
DOI: 10.1038/s41467-020-19481-7
PMID: 33184284
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-020-19481-7