دورية أكاديمية
Superoxide-anion triggers impairments of immune efficiency and stress response behaviors of Eisenia fetida earthworms.
| العنوان: | Superoxide-anion triggers impairments of immune efficiency and stress response behaviors of Eisenia fetida earthworms. |
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| المؤلفون: | Cruz Jung IED; Graduate Program of Pharmacology, Federal University of Santa Maria, Santa Maria, Brazil., Assmann CE; Graduate Program of Toxicological Biochemistry, Federal University of Santa Maria, Santa Maria, Brazil., Mastella MH; Graduate Program of Pharmacology, Federal University of Santa Maria, Santa Maria, Brazil., Barbisan F; Graduate Program of Pharmacology, Federal University of Santa Maria, Santa Maria, Brazil; Biogenomics Lab, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil; Graduate Program of Gerontology, Federal University of Santa Maria, Santa Maria, Brazil., Spilliari Ruaro RA; Biogenomics Lab, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil., Roggia I; Biogenomics Lab, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil; Graduate Program of Gerontology, Federal University of Santa Maria, Santa Maria, Brazil., Turra BO; Graduate Program of Pharmacology, Federal University of Santa Maria, Santa Maria, Brazil., Chitolina B; Biogenomics Lab, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil., de Oliveira Alves A; Graduate Program of Pharmacology, Federal University of Santa Maria, Santa Maria, Brazil., Teixeira CF; Graduate Program of Pharmacology, Federal University of Santa Maria, Santa Maria, Brazil., Azzolin VF; Biogenomics Lab, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil; Graduate Program of Gerontology, Federal University of Santa Maria, Santa Maria, Brazil., Ribeiro EE; Open University of the Third Age Foundation, State University of Amazonas, Manaus, Brazil., Medeiros Frescura Duarte MM; Graduate Program of Pharmacology, Federal University of Santa Maria, Santa Maria, Brazil., Mânica da Cruz IB; Graduate Program of Pharmacology, Federal University of Santa Maria, Santa Maria, Brazil; Biogenomics Lab, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil; Graduate Program of Gerontology, Federal University of Santa Maria, Santa Maria, Brazil. Electronic address: ivana.ufsm@gmail.com. |
| المصدر: | Chemosphere [Chemosphere] 2021 Apr; Vol. 269, pp. 128712. Date of Electronic Publication: 2020 Oct 22. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 0320657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1298 (Electronic) Linking ISSN: 00456535 NLM ISO Abbreviation: Chemosphere Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Science Ltd Original Publication: Oxford, New York, : Pergamon Press. |
| مواضيع طبية MeSH: | Oligochaeta*/genetics , Oligochaeta*/metabolism , Soil Pollutants*/toxicity, Animals ; Humans ; Hydrogen Peroxide ; Oxidative Stress ; Superoxide Dismutase/metabolism ; Superoxides |
| مستخلص: | Superoxide-hydrogen peroxide (S-HP), triggered by Val16Ala-SOD2 human polymorphism, may influence the risk of depression. Therefore, it is plausible that higher basal S-anion levels and chronic inflammatory states associated with the VV-SOD2 genotype can negatively modulate the stress response associated with resilience in various species, from primitive species to humans. To test this hypothesis, Eisenia fetida earthworms were exposed for 24 h to 30 nM rotenone, which causes mitochondrial dysfunction by generating high S-anion levels (known as the "VV-like phenotype"), and 10 μM porphyrin, a SOD2-like compound, which generates elevated HP levels (known as the "AA-like phenotype"). The results suggested that both S-anion and HP acted as signaling molecules, differentially altering the immune function and acute hydric stressful response. Although the AA-like phenotype improved the immune and stress response efficiencies, the VV-like phenotype showed a downregulated expression of the toll-like receptor (EaTLR, JX898685) and antimicrobial peptide (AMP) (AF060552) genes, which triggered the impairment of encapsulation and earthworms extracellular trap (EET) processes used by earthworms to trap and destroy microorganisms. When exposed to adverse environments and dangerous hydric stress, VV-like earthworms exhibited an impulsive behavior and failed to quickly identify and migrate to a protected environment, unlike control earthworms and AA-like earthworms. All results corroborated that the S-anion imbalance could concomitantly induce alterations in immune function and stress behavior related to earthworm survival. From a human perspective, this information may corroborate the potential specific role of superoxide anion in the modulation of the stress response, resilience, and risk of depression. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2020. Published by Elsevier Ltd.) |
| فهرسة مساهمة: | Keywords: Antimicrobial peptide gene; Eisenia fetida; Inflammation; Major depression; Superoxide dismutase 2; Toll-like receptor gene |
| المشرفين على المادة: | 0 (Soil Pollutants) 11062-77-4 (Superoxides) BBX060AN9V (Hydrogen Peroxide) EC 1.15.1.1 (Superoxide Dismutase) |
| تواريخ الأحداث: | Date Created: 20201115 Date Completed: 20210224 Latest Revision: 20210224 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.chemosphere.2020.128712 |
| PMID: | 33189402 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-1298 |
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| DOI: | 10.1016/j.chemosphere.2020.128712 |