دورية أكاديمية
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Effectiveness of Core-Shell Nanofibers Incorporating Amphotericin B by Solution Blow Spinning Against Leishmania and Candida Species.

التفاصيل البيبلوغرافية
العنوان: Effectiveness of Core-Shell Nanofibers Incorporating Amphotericin B by Solution Blow Spinning Against Leishmania and Candida Species.
المؤلفون: Gonçalves IMF; Human Immunology Research and Education Group (GEPIH), Escola Técnica de Saúde da UFPB, Federal University of Paraíba, João Pessoa, Brazil.; Postgraduate Program in Dentistry (PPGO), Federal University of Paraíba, João Pessoa, Brazil., Rocha ÍM; Human Immunology Research and Education Group (GEPIH), Escola Técnica de Saúde da UFPB, Federal University of Paraíba, João Pessoa, Brazil.; Postgraduate Program in Dentistry (PPGO), Federal University of Paraíba, João Pessoa, Brazil., Pires EG; Human Immunology Research and Education Group (GEPIH), Escola Técnica de Saúde da UFPB, Federal University of Paraíba, João Pessoa, Brazil.; Postgraduate Program in Dentistry (PPGO), Federal University of Paraíba, João Pessoa, Brazil., Muniz IAF; Human Immunology Research and Education Group (GEPIH), Escola Técnica de Saúde da UFPB, Federal University of Paraíba, João Pessoa, Brazil.; Postgraduate Program in Dentistry (PPGO), Federal University of Paraíba, João Pessoa, Brazil., Maciel PP; Human Immunology Research and Education Group (GEPIH), Escola Técnica de Saúde da UFPB, Federal University of Paraíba, João Pessoa, Brazil.; Postgraduate Program in Dentistry (PPGO), Federal University of Paraíba, João Pessoa, Brazil., de Lima JM; Human Immunology Research and Education Group (GEPIH), Escola Técnica de Saúde da UFPB, Federal University of Paraíba, João Pessoa, Brazil.; Postgraduate Program in Dentistry (PPGO), Federal University of Paraíba, João Pessoa, Brazil.; Postgraduate Program in Dentistry, Federal University of Pernambuco, Recife, Brazil., Dos Santos IMG; Fuel and Materials Laboratory (LACOM), Federal University of Paraíba, João Pessoa, Brazil., Batista RBD; Human Immunology Research and Education Group (GEPIH), Escola Técnica de Saúde da UFPB, Federal University of Paraíba, João Pessoa, Brazil.; Postgraduate Program in Dentistry, Federal University of Pernambuco, Recife, Brazil., de Medeiros ELG; Postgraduate Program in Materials Engineering, Federal University of Campina Grande, Campina Grande, Brazil., de Medeiros ES; Postgraduate Program in Dentistry (PPGO), Federal University of Paraíba, João Pessoa, Brazil.; Postgraduate Program in Materials Engineering, Federal University of Paraíba, João Pessoa, Brazil., de Oliveira JE; Department of Engineering, Federal University of Lavras, Lavras, Brazil., Goulart LR; Postgraduate Program in Health Sciences, School of Medicine, Federal University of Uberlândia, Uberlândia, Brazil.; Institute of Biochemistry and Genetics, Federal University of Uberlândia, Uberlândia, Brazil.; Department of Medical Microbiology and Immunology, University of California Davis, Davis, CA, United States., Bonan PRF; Human Immunology Research and Education Group (GEPIH), Escola Técnica de Saúde da UFPB, Federal University of Paraíba, João Pessoa, Brazil.; Postgraduate Program in Dentistry (PPGO), Federal University of Paraíba, João Pessoa, Brazil., Castellano LRC; Human Immunology Research and Education Group (GEPIH), Escola Técnica de Saúde da UFPB, Federal University of Paraíba, João Pessoa, Brazil.; Postgraduate Program in Dentistry (PPGO), Federal University of Paraíba, João Pessoa, Brazil.
المصدر: Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2020 Oct 30; Vol. 8, pp. 571821. Date of Electronic Publication: 2020 Oct 30 (Print Publication: 2020).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101632513 Publication Model: eCollection Cited Medium: Print ISSN: 2296-4185 (Print) Linking ISSN: 22964185 NLM ISO Abbreviation: Front Bioeng Biotechnol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Media S.A., [2013]-
مستخلص: The aim of this study was to develop polymeric nanofibers for controlled administration of Amphotericin B (AmpB), using the solution centrifugation technique, characterizing its microstructural and physical properties, release rate, and activity against Leishmania and Candida species. The core-shell nanofibers incorporated with AmpB were synthesized by Solution Blow Spinning (SBS) and characterized by scanning electron microscopy (SEM), differential scanning calorimetry, X-Ray diffraction, and drug release assay. In vitro leishmanicidal and antifungal activity were also evaluated. Fibrous membranes with uniform morphology and smooth surfaces were produced. The intensity of the diffraction peaks becomes slightly more pronounced, assuming the increased crystallization in PLA/PEG at high AmpB loadings. Drug release occurred and the solutions with nanofibers to encourage greater incorporation of AmpB showed a higher concentration. In the results of the experiment with promastigotes, the wells treated with nanofibers containing concentrations of AmpB at 0.25, 0.5, and 1%, did not have any viable cells, similar to the positive control. Various concentrations of AmpB improved the inhibition of fungal growth. The delivery system based on PLA/PEG nanofibers was properly developed for AmpB, presenting a controlled release and a successful encapsulation, as well as antifungal and antileishmanial activity.
(Copyright © 2020 Gonçalves, Rocha, Pires, Muniz, Maciel, de Lima, dos Santos, Batista, de Medeiros, de Medeiros, de Oliveira, Goulart, Bonan and Castellano.)
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فهرسة مساهمة: Keywords: amphotericin B; candidiasis; drug delivery systems; leishmaniasis; nanofibers
تواريخ الأحداث: Date Created: 20201116 Latest Revision: 20201117
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7662013
DOI: 10.3389/fbioe.2020.571821
PMID: 33195132
قاعدة البيانات: MEDLINE
الوصف
تدمد:2296-4185
DOI:10.3389/fbioe.2020.571821