دورية أكاديمية
Effectiveness of Core-Shell Nanofibers Incorporating Amphotericin B by Solution Blow Spinning Against Leishmania and Candida Species.
العنوان: | Effectiveness of Core-Shell Nanofibers Incorporating Amphotericin B by Solution Blow Spinning Against Leishmania and Candida Species. |
---|---|
المؤلفون: | Gonçalves IMF; Human Immunology Research and Education Group (GEPIH), Escola Técnica de Saúde da UFPB, Federal University of Paraíba, João Pessoa, Brazil.; Postgraduate Program in Dentistry (PPGO), Federal University of Paraíba, João Pessoa, Brazil., Rocha ÍM; Human Immunology Research and Education Group (GEPIH), Escola Técnica de Saúde da UFPB, Federal University of Paraíba, João Pessoa, Brazil.; Postgraduate Program in Dentistry (PPGO), Federal University of Paraíba, João Pessoa, Brazil., Pires EG; Human Immunology Research and Education Group (GEPIH), Escola Técnica de Saúde da UFPB, Federal University of Paraíba, João Pessoa, Brazil.; Postgraduate Program in Dentistry (PPGO), Federal University of Paraíba, João Pessoa, Brazil., Muniz IAF; Human Immunology Research and Education Group (GEPIH), Escola Técnica de Saúde da UFPB, Federal University of Paraíba, João Pessoa, Brazil.; Postgraduate Program in Dentistry (PPGO), Federal University of Paraíba, João Pessoa, Brazil., Maciel PP; Human Immunology Research and Education Group (GEPIH), Escola Técnica de Saúde da UFPB, Federal University of Paraíba, João Pessoa, Brazil.; Postgraduate Program in Dentistry (PPGO), Federal University of Paraíba, João Pessoa, Brazil., de Lima JM; Human Immunology Research and Education Group (GEPIH), Escola Técnica de Saúde da UFPB, Federal University of Paraíba, João Pessoa, Brazil.; Postgraduate Program in Dentistry (PPGO), Federal University of Paraíba, João Pessoa, Brazil.; Postgraduate Program in Dentistry, Federal University of Pernambuco, Recife, Brazil., Dos Santos IMG; Fuel and Materials Laboratory (LACOM), Federal University of Paraíba, João Pessoa, Brazil., Batista RBD; Human Immunology Research and Education Group (GEPIH), Escola Técnica de Saúde da UFPB, Federal University of Paraíba, João Pessoa, Brazil.; Postgraduate Program in Dentistry, Federal University of Pernambuco, Recife, Brazil., de Medeiros ELG; Postgraduate Program in Materials Engineering, Federal University of Campina Grande, Campina Grande, Brazil., de Medeiros ES; Postgraduate Program in Dentistry (PPGO), Federal University of Paraíba, João Pessoa, Brazil.; Postgraduate Program in Materials Engineering, Federal University of Paraíba, João Pessoa, Brazil., de Oliveira JE; Department of Engineering, Federal University of Lavras, Lavras, Brazil., Goulart LR; Postgraduate Program in Health Sciences, School of Medicine, Federal University of Uberlândia, Uberlândia, Brazil.; Institute of Biochemistry and Genetics, Federal University of Uberlândia, Uberlândia, Brazil.; Department of Medical Microbiology and Immunology, University of California Davis, Davis, CA, United States., Bonan PRF; Human Immunology Research and Education Group (GEPIH), Escola Técnica de Saúde da UFPB, Federal University of Paraíba, João Pessoa, Brazil.; Postgraduate Program in Dentistry (PPGO), Federal University of Paraíba, João Pessoa, Brazil., Castellano LRC; Human Immunology Research and Education Group (GEPIH), Escola Técnica de Saúde da UFPB, Federal University of Paraíba, João Pessoa, Brazil.; Postgraduate Program in Dentistry (PPGO), Federal University of Paraíba, João Pessoa, Brazil. |
المصدر: | Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2020 Oct 30; Vol. 8, pp. 571821. Date of Electronic Publication: 2020 Oct 30 (Print Publication: 2020). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101632513 Publication Model: eCollection Cited Medium: Print ISSN: 2296-4185 (Print) Linking ISSN: 22964185 NLM ISO Abbreviation: Front Bioeng Biotechnol Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media S.A., [2013]- |
مستخلص: | The aim of this study was to develop polymeric nanofibers for controlled administration of Amphotericin B (AmpB), using the solution centrifugation technique, characterizing its microstructural and physical properties, release rate, and activity against Leishmania and Candida species. The core-shell nanofibers incorporated with AmpB were synthesized by Solution Blow Spinning (SBS) and characterized by scanning electron microscopy (SEM), differential scanning calorimetry, X-Ray diffraction, and drug release assay. In vitro leishmanicidal and antifungal activity were also evaluated. Fibrous membranes with uniform morphology and smooth surfaces were produced. The intensity of the diffraction peaks becomes slightly more pronounced, assuming the increased crystallization in PLA/PEG at high AmpB loadings. Drug release occurred and the solutions with nanofibers to encourage greater incorporation of AmpB showed a higher concentration. In the results of the experiment with promastigotes, the wells treated with nanofibers containing concentrations of AmpB at 0.25, 0.5, and 1%, did not have any viable cells, similar to the positive control. Various concentrations of AmpB improved the inhibition of fungal growth. The delivery system based on PLA/PEG nanofibers was properly developed for AmpB, presenting a controlled release and a successful encapsulation, as well as antifungal and antileishmanial activity. (Copyright © 2020 Gonçalves, Rocha, Pires, Muniz, Maciel, de Lima, dos Santos, Batista, de Medeiros, de Medeiros, de Oliveira, Goulart, Bonan and Castellano.) |
References: | Mater Sci Eng C Mater Biol Appl. 2014 Jul 1;40:32-41. (PMID: 24857462) Med Oral Patol Oral Cir Bucal. 2019 Mar 1;24(2):e172-e180. (PMID: 30818309) Biotechnol Adv. 2010 May-Jun;28(3):325-47. (PMID: 20100560) Molecules. 2012 Oct 08;17(10):11729-47. (PMID: 23044711) PLoS Negl Trop Dis. 2014 May 01;8(5):e2832. (PMID: 24787001) Int J Nanomedicine. 2014 May 23;9:2439-58. (PMID: 24920895) Int J Pharm. 2015 Apr 30;484(1-2):57-74. (PMID: 25701683) Mater Sci Eng C Mater Biol Appl. 2020 May;110:110635. (PMID: 32204071) BMC Infect Dis. 2019 Jul 8;19(1):593. (PMID: 31286895) Acta Biomater. 2015 Apr;16:103-16. (PMID: 25617805) J Control Release. 2005 Jun 20;105(1-2):43-51. (PMID: 15908033) J Antimicrob Chemother. 2002 Feb;49 Suppl 1:7-10. (PMID: 11801575) Mater Sci Eng C Mater Biol Appl. 2013 Mar 1;33(2):844-9. (PMID: 25427496) Biomaterials. 2003 Dec;24(27):4977-85. (PMID: 14559011) Nanomedicine (Lond). 2015;10(11):1785-800. (PMID: 26080700) Braz Oral Res. 2009 Jul-Sep;23(3):255-62. (PMID: 19893959) J Control Release. 2004 Jul 23;98(1):47-56. (PMID: 15245888) J Biomed Mater Res A. 2017 Sep;105(9):2391-2404. (PMID: 28445626) Pharm Dev Technol. 2019 Sep;24(7):864-873. (PMID: 31046546) Eur J Pharm Sci. 2018 Nov 1;124:71-79. (PMID: 30145339) J Microbiol Methods. 2013 Aug;94(2):111-116. (PMID: 23707202) Artif Cells Nanomed Biotechnol. 2018;46(sup1):521-531. (PMID: 29385910) Nanomedicine (Lond). 2015 Jul;10(12):1959-71. (PMID: 26139128) Clin Dermatol. 2010 Mar 4;28(2):178-84. (PMID: 20347660) ACS Appl Mater Interfaces. 2015 Apr 22;7(15):8088-98. (PMID: 25768431) Mater Sci Eng C Mater Biol Appl. 2015 Mar;48:372-7. (PMID: 25579936) Head Neck Pathol. 2019 Mar;13(1):25-32. (PMID: 30693459) Materials (Basel). 2017 Jun 13;10(6):. (PMID: 28773009) Nanoscale. 2010 Apr;2(4):564-72. (PMID: 20644760) Prog Polym Sci. 2010 Jul 1;35(7):868-892. (PMID: 20582161) Acta Biomater. 2015 Dec;28:183-192. (PMID: 26391494) J Nanosci Nanotechnol. 2012 Mar;12(3):2733-41. (PMID: 22755116) Eur J Pharm Biopharm. 2010 Jun;75(2):96-106. (PMID: 20211727) PLoS Negl Trop Dis. 2015 Jul 31;9(7):e0003948. (PMID: 26230675) Adv Drug Deliv Rev. 2007 Jul 30;59(7):617-30. (PMID: 17597252) Int J Nanomedicine. 2015 Sep 01;10:5529-42. (PMID: 26366075) Int J Pharm. 2015 Oct 15;494(1):516-30. (PMID: 26307263) PLoS One. 2014 Jan 31;9(1):e87659. (PMID: 24498160) Parasitol Res. 2006 Jul;99(2):103-7. (PMID: 16506080) J Pharm Sci. 2018 Oct;107(10):2674-2685. (PMID: 29940181) Head Neck Pathol. 2016 Dec;10(4):533-537. (PMID: 27260217) Mater Sci Eng C Mater Biol Appl. 2020 Jul;112:110917. (PMID: 32409068) ACS Chem Neurosci. 2013 Sep 18;4(9):1314-21. (PMID: 23815098) Nanomaterials (Basel). 2019 Jan 08;9(1):. (PMID: 30626067) Chem Rev. 1999 Nov 10;99(11):3181-98. (PMID: 11749514) Acta Biomater. 2012 Feb;8(2):763-71. (PMID: 22100346) |
فهرسة مساهمة: | Keywords: amphotericin B; candidiasis; drug delivery systems; leishmaniasis; nanofibers |
تواريخ الأحداث: | Date Created: 20201116 Latest Revision: 20201117 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC7662013 |
DOI: | 10.3389/fbioe.2020.571821 |
PMID: | 33195132 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2296-4185 |
---|---|
DOI: | 10.3389/fbioe.2020.571821 |