دورية أكاديمية
أعرض في EDS

Randomised controlled trial to assess the effectiveness of apnoeic oxygenation in adults using low-flow or high-flow nasal cannula with head side elevation versus usual care to prevent desaturation during endotracheal intubation in the emergency department (ApOxED): study protocol.

التفاصيل البيبلوغرافية
العنوان: Randomised controlled trial to assess the effectiveness of apnoeic oxygenation in adults using low-flow or high-flow nasal cannula with head side elevation versus usual care to prevent desaturation during endotracheal intubation in the emergency department (ApOxED): study protocol.
المؤلفون: Waheed S; Emergency Medicine, Aga Khan University Hospital, Karachi, Sindh, Pakistan docshahan83@hotmail.com., Kapadia NN; Emergency Medicine, Aga Khan University Hospital, Karachi, Sindh, Pakistan., Khan MF; Department of Anaesthesiology, Aga Khan University Hospital, Karachi, Pakistan., Kerai SM; Emergency Medicine, Aga Khan University Hospital, Karachi, Sindh, Pakistan., Raheem A; Emergency Medicine, Aga Khan University Hospital, Karachi, Sindh, Pakistan., Naeem R; Emergency Medicine, Aga Khan University Hospital, Karachi, Sindh, Pakistan.
المصدر: BMJ open [BMJ Open] 2020 Nov 16; Vol. 10 (11), pp. e037964. Date of Electronic Publication: 2020 Nov 16.
نوع المنشور: Clinical Trial Protocol; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BMJ Publishing Group Ltd, 2011-
مواضيع طبية MeSH: Cannula* , Intubation, Intratracheal*, Adult ; Emergency Service, Hospital ; Humans ; Oxygen Inhalation Therapy ; Randomized Controlled Trials as Topic ; Respiration, Artificial
مستخلص: Introduction: Apnoeic oxygenation is a process of delivering continuous oxygen through nasal cannula during direct laryngoscopy. The oxygen that is delivered through these nasal cannulas is either low flow or high flow. Although the effectiveness of apnoeic oxygenation has been shown through systematic reviews and randomised controlled trials, a comparison of high-flow versus low-flow oxygen delivery has not been tested through a superiority study design. In this study we propose to assess the effectiveness of giving low-flow oxygen with head side elevation versus high-flow oxygen with head side elevation against the usual practice of care in which no oxygen is provided during direct laryngoscopy.
Methods and Analysis: This will be a three-arm study instituting a block randomisation technique with a sample size of 46 in each arm (see table 1). Due to the nature of the intervention, no blinding will be introduced. The primary outcomes will be lowest non-invasive oxygen saturation measurement during direct laryngoscopy and during the 2 min after the placement of the tube and the first pass success rate. The intervention constitutes head side elevation up to 30° for improving glottis visualisation together with low-flow or high-flow oxygen delivery through nasal cannula to increase safe apnoea time for participants undergoing endotracheal intubation. Primary analysis will be intention to treat.
Ethics and Dissemination: The study is approved by the Ethical Review Committee of Aga Khan University Hospital (2019-0726-2463). The project is an institution University Research Committee grant recipient 192 002ER-PK. The results of the study will be disseminated among participants, patient communities and healthcare professionals in the institution through seminars, presentations and emails. Further, the findings will be published in a highly accessed peer-reviewed medical journal and will be presented at both national and international conferences.
Trial Registration Number: ClinicalTrials.gov Registry (NCT04242537).
Competing Interests: Competing interests: None declared.
(© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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فهرسة مساهمة: Keywords: accident & emergency medicine; adult intensive & critical care; intensive & critical care
سلسلة جزيئية: ClinicalTrials.gov NCT04242537
تواريخ الأحداث: Date Created: 20201117 Date Completed: 20210514 Latest Revision: 20210514
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7670939
DOI: 10.1136/bmjopen-2020-037964
PMID: 33199418
قاعدة البيانات: MEDLINE
الوصف
تدمد:2044-6055
DOI:10.1136/bmjopen-2020-037964