Epidemiological and immunological features of obesity and SARS-CoV-2.
| العنوان: | Epidemiological and immunological features of obesity and SARS-CoV-2. |
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| المؤلفون: | Nilles EJ; Brigham and Women's Hospital, Boston, MA.; Harvard Medical School, Boston, MA.; Harvard Humanitarian Initiative, Boston, MA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA., Siddiqui SM; Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA.; Broad Institute of MIT and Harvard, Cambridge, MA., Fischinger S; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA., Bartsch YC; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA., de Saint Aubin M; Harvard Humanitarian Initiative, Boston, MA., Zhou G; Brigham and Women's Hospital, Boston, MA.; Harvard Medical School, Boston, MA., Gluck MJ; Space Exploration Technologies Corp, Hawthorne, CA.; Icahn School of Medicine- Mount Sinai, New York, NY., Berger S; Space Exploration Technologies Corp, Hawthorne, CA., Rhee J; Space Exploration Technologies Corp, Hawthorne, CA., Petersen E; Space Exploration Technologies Corp, Hawthorne, CA., Mormann B; Brigham and Women's Hospital, Boston, MA.; Space Exploration Technologies Corp, Hawthorne, CA., Loesche M; Brigham and Women's Hospital, Boston, MA.; Space Exploration Technologies Corp, Hawthorne, CA., Chen Z; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA., Yu J; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA.; Harvard T.H. Chan School of Public Health, Boston, MA., Gebre M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA.; Harvard T.H. Chan School of Public Health, Boston, MA., Atyeo C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA., Gorman MJ; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA., Lee Zhu A; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA., Burke J; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA., Slein M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA., Hasdianda MA; Brigham and Women's Hospital, Boston, MA.; Harvard Medical School, Boston, MA., Jambaulikar G; Brigham and Women's Hospital, Boston, MA.; Harvard Medical School, Boston, MA., Boyer E; Brigham and Women's Hospital, Boston, MA.; Harvard Medical School, Boston, MA., Sabeti P; Massachusetts Consortium on Pathogen Readiness, Boston, MA.; Broad Institute of MIT and Harvard, Cambridge, MA.; Harvard T.H. Chan School of Public Health, Boston, MA.; Howard Hughes Medical Institute, Chevy Chase, MD., Barouch DH; Broad Institute of MIT and Harvard, Cambridge, MA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA., Julg BD; Broad Institute of MIT and Harvard, Cambridge, MA., Kucharski AJ; London School of Hygiene and Tropical Medicine, London., Musk ER; Space Exploration Technologies Corp, Hawthorne, CA., Lauffenburger DA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA., Alter G; Massachusetts Consortium on Pathogen Readiness, Boston, MA.; Broad Institute of MIT and Harvard, Cambridge, MA., Menon AS; Space Exploration Technologies Corp, Hawthorne, CA. |
| المصدر: | MedRxiv : the preprint server for health sciences [medRxiv] 2020 Dec 11. Date of Electronic Publication: 2020 Dec 11. |
| نوع المنشور: | Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
| مستخلص: | Obesity is a key correlate of severe SARS-CoV-2 outcomes while the role of obesity on risk of SARS-CoV-2 infection, symptom phenotype, and immune response are poorly defined. We examined data from a prospective SARS-CoV-2 cohort study to address these questions. Serostatus, body mass index, demographics, comorbidities, and prior COVID-19 compatible symptoms were assessed at baseline and serostatus and symptoms monthly thereafter. SARS-CoV-2 immunoassays included an IgG ELISA targeting the spike RBD, multiarray Luminex targeting 20 viral antigens, pseudovirus neutralization, and T cell ELISPOT assays. Our results from a large prospective SARS-CoV-2 cohort study indicate symptom phenotype is strongly influenced by obesity among younger but not older age groups; we did not identify evidence to suggest obese individuals are at higher risk of SARS-CoV-2 infection; and, remarkably homogenous immune activity across BMI categories suggests natural- and vaccine-induced protection may be similar across these groups. |
| التعليقات: | Update in: Viruses. 2021 Nov 06;13(11):. (PMID: 34835041) |
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| معلومات مُعتمدة: | 206250/Z/17/Z United Kingdom WT_ Wellcome Trust; U19 AI135995 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: COVID-19; SARS-CoV-2; epidemiology; immunity; obesity |
| تواريخ الأحداث: | Date Created: 20201117 Latest Revision: 20231110 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7668749 |
| DOI: | 10.1101/2020.11.11.20229724 |
| PMID: | 33200139 |
| قاعدة البيانات: | MEDLINE |
| DOI: | 10.1101/2020.11.11.20229724 |
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