دورية أكاديمية
Clinically established biodegradable long acting injectables: An industry perspective.
| العنوان: | Clinically established biodegradable long acting injectables: An industry perspective. |
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| المؤلفون: | Nkanga CI; Center for Chemico- and Bio-Medicinal Research (CCBR), Department of Chemistry, Rhodes University, P.O. Box 94, Grahamstown 6140, South Africa; Faculty of Pharmaceutical Sciences, University of Kinshasa, B.P. 212, Kinshasa, XI, Democratic Republic of the Congo; Technical Research and Development, Novartis Pharma AG, Basel 4002, Switzerland., Fisch A; Technical Research and Development, Novartis Pharma AG, Basel 4002, Switzerland., Rad-Malekshahi M; Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran., Romic MD; Technical Research and Development, Novartis Pharma AG, Basel 4002, Switzerland., Kittel B; Novartis Institute for Biomedical Research, Novartis Pharma AG, Basel 4002, Switzerland., Ullrich T; Novartis Institute for Biomedical Research, Novartis Pharma AG, Basel 4002, Switzerland., Wang J; Technical Research and Development, Novartis Pharma AG, Basel 4002, Switzerland., Krause RWM; Center for Chemico- and Bio-Medicinal Research (CCBR), Department of Chemistry, Rhodes University, P.O. Box 94, Grahamstown 6140, South Africa., Adler S; Technical Research and Development, Novartis Pharma AG, Basel 4002, Switzerland., Lammers T; Department of Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany., Hennink WE; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, the Netherlands., Ramazani F; Technical Research and Development, Novartis Pharma AG, Basel 4002, Switzerland. Electronic address: farshad.ramazani@novartis.com. |
| المصدر: | Advanced drug delivery reviews [Adv Drug Deliv Rev] 2020 Dec; Vol. 167, pp. 19-46. Date of Electronic Publication: 2020 Nov 14. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Publishers, B.V Country of Publication: Netherlands NLM ID: 8710523 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8294 (Electronic) Linking ISSN: 0169409X NLM ISO Abbreviation: Adv Drug Deliv Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science Publishers, B.V., c1987- |
| مواضيع طبية MeSH: | Absorbable Implants*, Delayed-Action Preparations/*chemistry , Drug Delivery Systems/*methods , Drug Implants/*chemistry, Chemistry, Pharmaceutical ; Drug Liberation ; Emulsions/chemistry ; Humans ; Microspheres ; Nanoparticles/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; Suspensions/chemistry |
| مستخلص: | Long acting injectable formulations have been developed to sustain the action of drugs in the body over desired periods of time. These delivery platforms have been utilized for both systemic and local drug delivery applications. This review gives an overview of long acting injectable systems that are currently in clinical use. These products are categorized in three different groups: biodegradable polymeric systems, including microparticles and implants; micro and nanocrystal suspensions and oil-based formulations. Furthermore, the applications of these drug delivery platforms for the management of various chronic diseases are summarized. Finally, this review addresses industrial challenges regarding the development of long acting injectable formulations. (Copyright © 2020 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Drug crystal suspensions; Drug crystals; Drug delivery; Extended release; Implants; In situ forming implants; Long acting injectables; Microspheres; Oil-based formulations; PLGA microparticles |
| المشرفين على المادة: | 0 (Delayed-Action Preparations) 0 (Drug Implants) 0 (Emulsions) 0 (Suspensions) 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer) |
| تواريخ الأحداث: | Date Created: 20201117 Date Completed: 20210920 Latest Revision: 20210920 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.addr.2020.11.008 |
| PMID: | 33202261 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-8294 |
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| DOI: | 10.1016/j.addr.2020.11.008 |