دورية أكاديمية
أعرض في EDS

Opioid Preconditioning Modulates Repair Responses to Prevent Renal Ischemia-Reperfusion Injury.

التفاصيل البيبلوغرافية
العنوان: Opioid Preconditioning Modulates Repair Responses to Prevent Renal Ischemia-Reperfusion Injury.
المؤلفون: Franco-Acevedo A; Doctorado en Farmacologia, Universidad de Guadalajara, Guadalajara 44340, Mexico., Echavarria R; CONACyT-Centro de Investigacion Biomedica de Occidente, Instituto Mexicano de Seguro Social, Guadalajara 44340, Mexico., Moreno-Carranza B; Escuela de Ciencias de la Salud, Universidad Anahuac Queretaro, Queretaro 76246, Mexico., Ortiz CI; Surgical Research Division, Centro de Investigacion Biomedica de Occidente, Instituto Mexicano de Seguro Social, Guadalajara 44340, Mexico., Garcia D; Surgical Research Division, Centro de Investigacion Biomedica de Occidente, Instituto Mexicano de Seguro Social, Guadalajara 44340, Mexico., Gonzalez-Gonzalez R; Surgical Research Division, Centro de Investigacion Biomedica de Occidente, Instituto Mexicano de Seguro Social, Guadalajara 44340, Mexico., Bitzer-Quintero OK; Surgical Research Division, Centro de Investigacion Biomedica de Occidente, Instituto Mexicano de Seguro Social, Guadalajara 44340, Mexico., Portilla-De Buen E; Surgical Research Division, Centro de Investigacion Biomedica de Occidente, Instituto Mexicano de Seguro Social, Guadalajara 44340, Mexico., Melo Z; CONACyT-Centro de Investigacion Biomedica de Occidente, Instituto Mexicano de Seguro Social, Guadalajara 44340, Mexico.
المصدر: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2020 Nov 14; Vol. 13 (11). Date of Electronic Publication: 2020 Nov 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print) Linking ISSN: 14248247 NLM ISO Abbreviation: Pharmaceuticals (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c2004-
مستخلص: Progression to renal damage by ischemia-reperfusion injury (IRI) is the result of the dysregulation of various tissue damage repair mechanisms. Anesthetic preconditioning with opioids has been shown to be beneficial in myocardial IRI models. Our main objective was to analyze the influence of pharmacological preconditioning with opioids in renal function and expression of molecules involved in tissue repair and angiogenesis. Experimental protocol includes male rats with 45 min ischemia occluding the left renal hilum followed by 24 h of reperfusion with or without 60 min preconditioning with morphine/fentanyl. We analyzed serum creatinine and renal KIM-1 expression. We measured circulating and intrarenal VEGF. Immunohistochemistry for HIF-1 and Cathepsin D (CTD) and real-time PCR for angiogenic genes HIF-1α , VEGF , VEGF Receptor 2 ( VEGF-R2 ), CTD , CD31 and IL-6 were performed. These molecules are considered important effectors of tissue repair responses mediated by the development of new blood vessels. We observed a decrease in acute renal injury mediated by pharmacological preconditioning with opioids. Renal function in opioid preconditioning groups was like in the sham control group. Both anesthetics modulated the expression of HIF-1, VEGF, VEGF-R2 and CD31. Preconditioning negatively regulated CTD. Opioid preconditioning decreased injury through modulation of angiogenic molecule expression. These are factors to consider when establishing strategies in pathophysiological and surgical processes.
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معلومات مُعتمدة: PN-2016/2889 Consejo Nacional de Ciencia y Tecnología; INFR 230792 Consejo Nacional de Ciencia y Tecnología; Catedras-653 Consejo Nacional de Ciencia y Tecnología
فهرسة مساهمة: Keywords: angiogenesis; fentanyl; morphine; opioids; renal ischemia-reperfusion; wound healing
تواريخ الأحداث: Date Created: 20201118 Latest Revision: 20201201
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7696679
DOI: 10.3390/ph13110387
PMID: 33202532
قاعدة البيانات: MEDLINE
الوصف
تدمد:1424-8247
DOI:10.3390/ph13110387