دورية أكاديمية
AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth.
| العنوان: | AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth. |
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| المؤلفون: | Sari IN; Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, Republic of Korea., Yang YG; Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, Republic of Korea.; Shenzhen Key Laboratory of Viral Oncology, The Clinical Innovation & Research Center (CIRC), Shenzhen Hospital, Southern Medical University, Shenzhen, China., Wijaya YT; Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, Republic of Korea., Jun N; Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, Republic of Korea., Lee S; Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, Republic of Korea., Kim KS; Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, Republic of Korea., Bajaj J; Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Oehler VG; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Kim SH; Catholic Leukemia Research Institute, The Catholic University of Korea, Seoul, Republic of Korea., Choi SY; Catholic Leukemia Research Institute, The Catholic University of Korea, Seoul, Republic of Korea., Park SH; Catholic Leukemia Research Institute, The Catholic University of Korea, Seoul, Republic of Korea., Kim DW; Catholic Leukemia Research Institute, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Hematology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea., Reya T; Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA.; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, 27710, USA., Han J; Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, Republic of Korea., Kwon HY; Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, Republic of Korea. hykwon@sch.ac.kr. |
| المصدر: | Oncogene [Oncogene] 2021 Jan; Vol. 40 (3), pp. 603-617. Date of Electronic Publication: 2020 Nov 17. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2002->: Basingstoke : Nature Publishing Group Original Publication: Basingstoke, Hampshire, UK : Scientific & Medical Division, MacMillan Press, c1987- |
| مواضيع طبية MeSH: | Cell Proliferation*, Adenosylmethionine Decarboxylase/*metabolism , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*enzymology , Neoplasm Proteins/*metabolism , Neoplastic Stem Cells/*enzymology, Adenosylmethionine Decarboxylase/genetics ; Animals ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Mice ; Neoplasm Proteins/genetics ; Reactive Oxygen Species/metabolism |
| مستخلص: | Polyamines are critical elements in mammals, but it remains unknown whether adenosyl methionine decarboxylase (AMD1), a rate-limiting enzyme in polyamine synthesis, is required for myeloid leukemia. Here, we found that leukemic stem cells (LSCs) were highly differentiated, and leukemia progression was severely impaired in the absence of AMD1 in vivo. AMD1 was highly upregulated as chronic myeloid leukemia (CML) progressed from the chronic phase to the blast crisis phase, and was associated with the poor prognosis of CML patients. In addition, the pharmacological inhibition of AMD1 by AO476 treatment resulted in a robust reduction of the progression of leukemic cells both in vitro and in vivo. Mechanistically, AMD1 depletion induced loss of mitochondrial membrane potential and accumulation of reactive oxygen species (ROS), resulting in the differentiation of LSCs via oxidative stress and aberrant activation of unfolded protein response (UPR) pathway, which was partially rescued by the addition of polyamine. These results indicate that AMD1 is an essential element in the progression of myeloid leukemia and could be an attractive target for the treatment of the disease. |
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| المشرفين على المادة: | 0 (Neoplasm Proteins) 0 (Reactive Oxygen Species) EC 4.1.1.50 (AMD1 protein, human) EC 4.1.1.50 (Adenosylmethionine Decarboxylase) |
| تواريخ الأحداث: | Date Created: 20201118 Date Completed: 20210726 Latest Revision: 20220417 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1038/s41388-020-01547-x |
| PMID: | 33203990 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1476-5594 |
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| DOI: | 10.1038/s41388-020-01547-x |