دورية أكاديمية
أعرض في EDS

Eosinopenia as predictor of infection in patients admitted to an internal medicine ward: a cross-sectional study.

التفاصيل البيبلوغرافية
العنوان: Eosinopenia as predictor of infection in patients admitted to an internal medicine ward: a cross-sectional study.
المؤلفون: Silva JM; Interno de Formação Específica em Medicina Interna., Costa AM; Interno de Formação Específica em Medicina Interna., Tuna C; Interno de Formação Específica em Medicina Interna., Gonçalves R; Interno de Formação Específica em Medicina Interna., Ferreira S; Interno de Formação Específica em Medicina Interna., Belém F; Interno de Formação Específica em Medicina Interna., Evangelista MC; Assistente Hospitalar em Medicina Interna., Ascensão M; Assistente Hospitalar Graduada Sénior em Medicina Interna, Internal Medicine Department, Centro Hospitalar Universitário Cova da Beira, Covilhã, Portugal.
المصدر: Porto biomedical journal [Porto Biomed J] 2020 Nov 11; Vol. 5 (6), pp. e084. Date of Electronic Publication: 2020 Nov 11 (Print Publication: 2020).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Country of Publication: United States NLM ID: 101707479 Publication Model: eCollection Cited Medium: Internet ISSN: 2444-8672 (Electronic) Linking ISSN: 24448664 NLM ISO Abbreviation: Porto Biomed J Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2018- : [Philadelphia, PA] : Wolters Kluwer
Original Publication: [Barcelona] : Elsevier España, S.L.U., [2016]-[2017]
مستخلص: Background: The identification of infection in an internal medicine ward is crucial but not always straightforward. Eosinopenia has been proposed as a marker of infection, but specific cutoffs for prediction are not established yet. We aim to assess whether there is difference in eosinophil count between infected and noninfected patients and, if so, the best cutoffs to differentiate them.
Methods: Cross-sectional, observational study with analysis of all patients admitted to an Internal Medicine Department during 2 consecutive months. Clinical, laboratory and imaging data were analyzed. Infection at hospital admission was defined in the presence of either a microbiological isolation or suggestive clinical, laboratory, and/or imaging findings. Use of antibiotics in the 8 days before hospital admission, presence of immunosuppression, hematologic neoplasms, parasite, or fungal infections were exclusion criteria. In case of multiple hospital admissions, only the first admission was considered.Sensitivity and specificity values for eosinophils, leukocytes, neutrophils, and C-reactive protein were determined by receiver operating characteristic curve. Statistical analysis was performed with IBM SPSS Statistics® v25 and MedCalc Statistical Software® v19.2.3.
Results: A total of 323 hospitalization episodes were evaluated, each corresponding to a different patient. One hundred fifteen patients were excluded. A total of 208 patients were included, 62.0% (n = 129) of them infected at admission. Ten patients had multiple infections.Infected patients had fewer eosinophils than uninfected patients (15.8 ± 42 vs 71.1 ± 159 cell/mm 3 ; P  < .001). An eosinophil count at admission ≤69 cell/mm 3 had a sensitivity of 89.1% and specificity of 54.4% (area under the curve 0.752; 95% confidence interval 0.682-0.822) for the presence of infection. Eosinophil count of >77 cells/mm 3 had a negative likelihood ratio of 0.16.
Conclusions: Eosinophil count was significantly lower in infected than in uninfected patients. The cutoff 69 cells/mm 3 was the most accurate in predicting infection. Eosinophil count >77 cells/mm 3 was a good predictor of absence of infection.
Competing Interests: Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.The authors declare no conflicts of interest.
(Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of PBJ-Associação Porto Biomedical/Porto Biomedical Society. All rights reserved.)
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فهرسة مساهمة: Keywords: C-reactive protein; eosinopenia; eosinophil count; infection; leukogram
تواريخ الأحداث: Date Created: 20201118 Latest Revision: 20220418
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7665260
DOI: 10.1097/j.pbj.0000000000000084
PMID: 33204891
قاعدة البيانات: MEDLINE
الوصف
تدمد:2444-8672
DOI:10.1097/j.pbj.0000000000000084