دورية أكاديمية
Green synthesis of methoxy-poly(ethylene glycol)-block-poly(l-lactide-co-glycolide) copolymer using zinc proline as a biocompatible initiator for irinotecan delivery to colon cancer in vivo.
| العنوان: | Green synthesis of methoxy-poly(ethylene glycol)-block-poly(l-lactide-co-glycolide) copolymer using zinc proline as a biocompatible initiator for irinotecan delivery to colon cancer in vivo. |
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| المؤلفون: | Giram PS; Polymer Science and Engineering Division, CSIR-National Chemical Laboratory, Pune-411008, India. b.garnaik@ncl.res., Wang JT, Walters AA, Rade PP, Akhtar M, Han S, Faruqu FN, Abdel-Bar HM, Garnaik B, Al-Jamal KT |
| المصدر: | Biomaterials science [Biomater Sci] 2021 Feb 07; Vol. 9 (3), pp. 795-806. Date of Electronic Publication: 2020 Nov 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101593571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-4849 (Electronic) Linking ISSN: 20474830 NLM ISO Abbreviation: Biomater Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, UK : Royal Society of Chemistry |
| مواضيع طبية MeSH: | Colonic Neoplasms*/drug therapy , Nanoparticles* , Pharmaceutical Preparations*, Dioxanes ; Drug Carriers ; Humans ; Irinotecan ; Particle Size ; Polyethylene Glycols ; Proline ; Zinc |
| مستخلص: | Poly(lactic-co-glycolic acid) (PLGA) is the most commonly described biocompatible copolymer used in biomedical applications. In this work, a green synthetic approach based on the biocompatible zinc proline complex, as an initiator for PLGA synthesis, is reported for the first time for the synthesis of methoxy-poly(ethylene glycol)-block-poly(l-lactic-co-glycolic acid) (mPEG-PLGA). mPEG-PLGA with controlled molecular weight and narrow polydispersity was synthesised. Its potential for delivery of irinotecan (Ir), a poorly water-soluble chemotherapeutic drug used for the treatment of colon and pancreatic cancer, was studied. Nanoparticles of controlled size (140-160 nm), surface charge (∼-10 mV), release properties and cytotoxicity against CT-26 (colon) and BxPC-3 (pancreatic) cancer cells, were prepared. Tumor accumulation was confirmed by optical imaging of fluorescently labelled nanoparticles. Unlike Tween® 80 coated NP-Ir, the Pluronic® F-127 coated NP-Ir exhibits significant tumor growth delay compared to untreated and blank formulation treated groups in the CT-26 subcutaneous tumor model, after 4 treatments of 30 mg irinotecan per kg dose. Overall, this proof-of-concept study demonstrates that the newly synthesized copolymer, via a green route, is proven to be nontoxic, requires fewer purification steps and has potential applications in drug delivery. |
| المشرفين على المادة: | 0 (Dioxanes) 0 (Drug Carriers) 0 (Pharmaceutical Preparations) 3WJQ0SDW1A (Polyethylene Glycols) 7673326042 (Irinotecan) 95-96-5 (dilactide) 9DLQ4CIU6V (Proline) J41CSQ7QDS (Zinc) |
| تواريخ الأحداث: | Date Created: 20201118 Date Completed: 20210514 Latest Revision: 20210514 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1039/d0bm01421d |
| PMID: | 33206082 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2047-4849 |
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| DOI: | 10.1039/d0bm01421d |