دورية أكاديمية
Bone marrow Tregs mediate stromal cell function and support hematopoiesis via IL-10.
| العنوان: | Bone marrow Tregs mediate stromal cell function and support hematopoiesis via IL-10. |
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| المؤلفون: | Camacho V; Division of Hematology-Oncology., Matkins VR; Division of Hematology-Oncology., Patel SB; Division of Hematology-Oncology., Lever JM; Nephrology Research and Training Center, Division of Nephrology, Department of Medicine, and., Yang Z; Division of Cardiothoracic Surgery, Department of Surgery, The University of Alabama at Birmingham, Birmingham, Alabama, USA., Ying L; Cancer Science Institute of Singapore & Department of Biochemistry, National University of Singapore, Singapore., Landuyt AE; Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Dean EC; Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA., George JF; Division of Cardiothoracic Surgery, Department of Surgery, The University of Alabama at Birmingham, Birmingham, Alabama, USA., Yang H; Cancer Science Institute of Singapore & Department of Biochemistry, National University of Singapore, Singapore., Ferrell PB; Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Maynard CL; Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Weaver CT; Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Turnquist HR; Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Welner RS; Division of Hematology-Oncology. |
| المصدر: | JCI insight [JCI Insight] 2020 Nov 19; Vol. 5 (22). Date of Electronic Publication: 2020 Nov 19. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Ann Arbor, Michigan : American Society for Clinical Investigation, [2016]- |
| مواضيع طبية MeSH: | Hematopoiesis*, Bone Marrow Cells/*physiology , Hematopoietic Stem Cells/*physiology , Interleukin-10/*metabolism , Mesenchymal Stem Cells/*physiology , Stromal Cells/*physiology , T-Lymphocytes, Regulatory/*immunology, Animals ; Bone Marrow Cells/cytology ; Bone Marrow Cells/immunology ; Cell Communication ; Cell Proliferation ; Cells, Cultured ; Coculture Techniques ; Female ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/immunology ; Male ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/immunology ; Mice ; Mice, Inbred C57BL ; Stromal Cells/cytology ; Stromal Cells/immunology |
| مستخلص: | The nonimmune roles of Tregs have been described in various tissues, including the BM. In this study, we comprehensively phenotyped marrow Tregs, elucidating their key features and tissue-specific functions. We show that marrow Tregs are migratory and home back to the marrow. For trafficking, marrow Tregs use S1P gradients, and disruption of this axis allows for specific targeting of the marrow Treg pool. Following Treg depletion, the function and phenotype of both mesenchymal stromal cells (MSCs) and hematopoietic stem cells (HSCs) was impaired. Transplantation also revealed that a Treg-depleted niche has a reduced capacity to support hematopoiesis. Finally, we found that marrow Tregs are high producers of IL-10 and that Treg-secreted IL-10 has direct effects on MSC function. This is the first report to our knowledge revealing that Treg-secreted IL-10 is necessary for stromal cell maintenance, and our work outlines an alternative mechanism by which this cytokine regulates hematopoiesis. |
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| معلومات مُعتمدة: | K12 CA090625 United States CA NCI NIH HHS; K23 HL138291 United States HL NHLBI NIH HHS; R01 HL150078 United States HL NHLBI NIH HHS; T32 AI007051 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: Bone marrow; Hematology; Hematopoietic stem cells; Immunology; T cells |
| المشرفين على المادة: | 0 (IL10 protein, mouse) 130068-27-8 (Interleukin-10) |
| تواريخ الأحداث: | Date Created: 20201119 Date Completed: 20210607 Latest Revision: 20230223 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7710301 |
| DOI: | 10.1172/jci.insight.135681 |
| PMID: | 33208555 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2379-3708 |
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| DOI: | 10.1172/jci.insight.135681 |