دورية أكاديمية
Eltrombopag preferentially expands haematopoietic multipotent progenitors in human aplastic anaemia.
| العنوان: | Eltrombopag preferentially expands haematopoietic multipotent progenitors in human aplastic anaemia. |
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| المؤلفون: | Quintino de Oliveira B; Department of Medical Imaging, Haematology, and Clinical Oncology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil., Catto LFB; Department of Medical Imaging, Haematology, and Clinical Oncology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil., Santana BAA; Department of Medical Imaging, Haematology, and Clinical Oncology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil., Tellechea MF; Department of Medical Imaging, Haematology, and Clinical Oncology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil., Scheucher PS; Department of Medical Imaging, Haematology, and Clinical Oncology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil., Scheinberg P; Division of Haematology, Hospital A Beneficência Portuguesa, São Paulo, SP, Brazil., Calado RT; Department of Medical Imaging, Haematology, and Clinical Oncology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil. |
| المصدر: | British journal of haematology [Br J Haematol] 2021 Apr; Vol. 193 (2), pp. 410-414. Date of Electronic Publication: 2020 Nov 20. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Wiley-Blackwell Original Publication: Oxford : Blackwell Scientific Publications |
| مواضيع طبية MeSH: | Anemia, Aplastic/*drug therapy , Benzoates/*pharmacology , Hematopoietic Stem Cells/*drug effects , Hydrazines/*pharmacology , Multipotent Stem Cells/*drug effects , Pyrazoles/*pharmacology , Receptors, Thrombopoietin/*agonists, Adolescent ; Adult ; Antigens, CD34/drug effects ; Benzoates/administration & dosage ; Biopsy, Needle/methods ; Bone Marrow Cells/cytology ; Bone Marrow Cells/drug effects ; Bone Marrow Cells/pathology ; Brazil/epidemiology ; Female ; Flow Cytometry/methods ; Hematopoietic Stem Cells/cytology ; Humans ; Hydrazines/administration & dosage ; Immunosuppressive Agents/therapeutic use ; Male ; Middle Aged ; Multipotent Stem Cells/cytology ; Pyrazoles/administration & dosage |
| مستخلص: | Eltrombopag has been added to first-line treatment of immune aplastic anaemia (AA), resulting in higher responses. We analysed marrow samples of AA patients who responded to immunosuppressive therapy (IST) alone or in combination with eltrombopag for the composition of the haematopoietic stem and progenitor cell (HSPC) compartment. The number of CD34 + cells and multipotent progenitors was higher in patients treated with eltrombopag (P < 0·005; P < 0·05; respectively), but not the number of stem cells. No aberrant phenotype was observed. These results indicate that eltrombopag augments CD34 + cells in vivo and preferentially expands multipotent progenitors, but not stem cells. (© 2020 British Society for Haematology and John Wiley & Sons Ltd.) |
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| فهرسة مساهمة: | Keywords: aplastic anaemia; eltrombopag; flow cytometry; haematopoietic stem cells; thrombopoietin receptor agonist |
| المشرفين على المادة: | 0 (Antigens, CD34) 0 (Benzoates) 0 (Hydrazines) 0 (Immunosuppressive Agents) 0 (Pyrazoles) 0 (Receptors, Thrombopoietin) 143641-95-6 (MPL protein, human) S56D65XJ9G (eltrombopag) |
| تواريخ الأحداث: | Date Created: 20201120 Date Completed: 20210924 Latest Revision: 20210924 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1111/bjh.17140 |
| PMID: | 33216370 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1365-2141 |
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| DOI: | 10.1111/bjh.17140 |