دورية أكاديمية
أعرض في EDS

Epidemiologic and clinical investigations during a chikungunya outbreak in Rio Grande do Norte State, Brazil.

التفاصيل البيبلوغرافية
العنوان: Epidemiologic and clinical investigations during a chikungunya outbreak in Rio Grande do Norte State, Brazil.
المؤلفون: Monteiro JD; Immunogenetics Laboratory, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil.; Post-Graduate Program in Parasite Biology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Laboratory of Molecular Biology for Infectious Diseases and Cancer, Department of Microbiology and Parasitology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Laboratory of Virology, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil.; Post-Graduate Program in Health Sciences, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil., Valverde JG; Immunogenetics Laboratory, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil.; Laboratory of Complex Diseases, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil.; Institute of Science and Technology of Tropical Diseases, Brazil., Morais IC; Institute of Science and Technology of Tropical Diseases, Brazil., Souza CRM; Immunogenetics Laboratory, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil.; Laboratory of Complex Diseases, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil.; Institute of Science and Technology of Tropical Diseases, Brazil., Fagundes Neto JC; Post-Graduate Program in Parasite Biology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Laboratory of Molecular Biology for Infectious Diseases and Cancer, Department of Microbiology and Parasitology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Laboratory of Virology, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil., Melo MF; Post-Graduate Program in Parasite Biology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Laboratory of Molecular Biology for Infectious Diseases and Cancer, Department of Microbiology and Parasitology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Laboratory of Virology, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil., Nascimento YM; Laboratory of Molecular Biology for Infectious Diseases and Cancer, Department of Microbiology and Parasitology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Laboratory of Virology, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil., Alves BEB; Post-Graduate Program in Parasite Biology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Laboratory of Molecular Biology for Infectious Diseases and Cancer, Department of Microbiology and Parasitology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Laboratory of Virology, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil., Medeiros LG; Post-Graduate Program in Parasite Biology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Laboratory of Molecular Biology for Infectious Diseases and Cancer, Department of Microbiology and Parasitology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Laboratory of Virology, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil., Pereira HWB; Post-Graduate Program in Parasite Biology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Laboratory of Molecular Biology for Infectious Diseases and Cancer, Department of Microbiology and Parasitology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Laboratory of Virology, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil., Paiva AAP; Laboratory of Molecular Biology for Infectious Diseases and Cancer, Department of Microbiology and Parasitology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Laboratory of Virology, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil., Teixeira DG; Immunogenetics Laboratory, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil.; Laboratory of Complex Diseases, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil.; Institute of Science and Technology of Tropical Diseases, Brazil., Moura MCBM; Secretaria Municipal de Saúde, Centro de Controle de Zoonoses, Natal, Brazil., Tavares AM; Secretaria Municipal de Saúde, Centro de Controle de Zoonoses, Natal, Brazil., Fernandes JV; Post-Graduate Program in Parasite Biology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Laboratory of Molecular Biology for Infectious Diseases and Cancer, Department of Microbiology and Parasitology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil., Jeronimo SMB; Immunogenetics Laboratory, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil.; Post-Graduate Program in Health Sciences, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Laboratory of Complex Diseases, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil.; Institute of Science and Technology of Tropical Diseases, Brazil., Araújo JMG; Post-Graduate Program in Parasite Biology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Laboratory of Molecular Biology for Infectious Diseases and Cancer, Department of Microbiology and Parasitology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Laboratory of Virology, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil.
المصدر: PloS one [PLoS One] 2020 Nov 20; Vol. 15 (11), pp. e0241799. Date of Electronic Publication: 2020 Nov 20 (Print Publication: 2020).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Chikungunya Fever/*epidemiology, Antibodies, Viral/immunology ; Brazil/epidemiology ; Chikungunya Fever/genetics ; Chikungunya Fever/immunology ; Chikungunya virus/genetics ; Chikungunya virus/immunology ; Chikungunya virus/pathogenicity ; Disease Outbreaks ; Enzyme-Linked Immunosorbent Assay ; Female ; Genotype ; Humans ; Male ; RNA, Viral/genetics ; Real-Time Polymerase Chain Reaction
مستخلص: The first autochthonous case of chikungunya virus (CHIKV) infection in Brazil was in September 2014 in the State of Amapá, and from there it rapidly spread across the country. The present study was conducted in 2016 in the state of Rio Grande do Norte, and the aims were to describe the epidemiological and the clinical aspects of the CHIKV outbreak. Biological samples from 284 chikungunya suspected cases were screened for CHIKV and Flavivirus (FV) RNA using qRT-PCR. Negative PCR samples were also screened for anti-CHIKV and anti-FVIgM by ELISA. CHIKV RNA were detected in 125 samples mostly occurring from January through March (46%), mainly affecting adults and older adults. We found a gradual decrease in viral RNA over the disease time. Anti-CHIKV IgM was found in 47.5% after negative CHIKV qRT-PCR. Interestingly, 45.0% simultaneously had positive results for CHIKV and FV IgM, suggesting the occurrence of virus co-circulation. The most frequent symptom was fever (91%). Women presented more chance to develop nausea and abdominal pain compared to men. Our data described and allows us to better understand the clinical and epidemiological aspects of the 2016 chikungunya outbreak in Rio Grande do Norte and can help in the early clinical diagnosis of the virus.
Competing Interests: No authors have competing interests.
References: Nat Rev Rheumatol. 2012 May 08;8(7):420-9. (PMID: 22565316)
Neurocrit Care. 2017 Dec;27(3):447-457. (PMID: 28741102)
Cad Saude Publica. 2015 May;31(5):906-8. (PMID: 26083166)
PLoS Negl Trop Dis. 2017 Jul 27;11(7):e0005724. (PMID: 28749964)
PLoS Negl Trop Dis. 2017 Jan 20;11(1):e0005319. (PMID: 28107342)
Clin Chem. 2007 Aug;53(8):1408-14. (PMID: 17586592)
Sci Rep. 2019 Feb 26;9(1):2760. (PMID: 30809003)
Emerg Infect Dis. 2015 Dec;21(12):2274-6. (PMID: 26584464)
New Microbiol. 2013 Jul;36(3):211-27. (PMID: 23912863)
Emerg Infect Dis. 2012 Mar;18(3):529-30. (PMID: 22377013)
PLoS Curr. 2018 Feb 15;10:. (PMID: 29588874)
Rev Saude Publica. 2017 Apr 10;51:30. (PMID: 28423140)
Eur J Pediatr. 2010 Jan;169(1):67-72. (PMID: 19401826)
J Clin Microbiol. 1992 Mar;30(3):545-51. (PMID: 1372617)
Rev Soc Bras Med Trop. 2019 Feb 21;52:e20180429. (PMID: 30810657)
PLoS One. 2017 Nov 16;12(11):e0188002. (PMID: 29145452)
Lancet Infect Dis. 2017 Apr;17(4):e107-e117. (PMID: 28159534)
Int J Infect Dis. 2015 Sep;38:60-1. (PMID: 26216764)
BMC Infect Dis. 2009 Dec 10;9:200. (PMID: 20003320)
Nat Struct Mol Biol. 2016 Sep;23(9):865-7. (PMID: 27455458)
Emerg Infect Dis. 2007 May;13(5):764-7. (PMID: 17553261)
J Immunol Methods. 1998 Dec 1;221(1-2):35-41. (PMID: 9894896)
Lancet Infect Dis. 2007 May;7(5):319-27. (PMID: 17448935)
PLoS Curr. 2017 Feb 14;9:. (PMID: 28286701)
BMC Infect Dis. 2010 Feb 19;10:31. (PMID: 20170492)
Cien Saude Colet. 2016 Feb;21(2):641-6. (PMID: 26910171)
Trans R Soc Trop Med Hyg. 1955 Jan;49(1):28-32. (PMID: 14373834)
Virol J. 2013 Oct 22;10:311. (PMID: 24148652)
BMC Med. 2015 Apr 30;13:102. (PMID: 25976325)
Int J Dermatol. 2011 Jan;50(1):61-9. (PMID: 21182504)
Clin Infect Dis. 2019 Sep 27;69(8):1353-1359. (PMID: 30561554)
Reumatol Clin. 2015 May-Jun;11(3):161-4. (PMID: 25192946)
PLoS Negl Trop Dis. 2013;7(1):e2004. (PMID: 23350006)
J Gen Virol. 2018 Jun;99(6):761-762. (PMID: 29745869)
Rambam Maimonides Med J. 2016 Oct 31;7(4):. (PMID: 27824550)
Int J Dermatol. 2008 Feb;47(2):154-9. (PMID: 18211486)
PLoS One. 2019 Feb 1;14(2):e0211036. (PMID: 30707708)
J Lab Physicians. 2016 Jul-Dec;8(2):85-9. (PMID: 27365916)
Rev Saude Publica. 2015;49:58. (PMID: 26398876)
Science. 2016 Aug 19;353(6301):823-6. (PMID: 27417494)
J Rheumatol. 1980 Mar-Apr;7(2):231-6. (PMID: 7373626)
PLoS Negl Trop Dis. 2010 Apr 27;4(4):e623. (PMID: 20436958)
Natl Med J India. 2006 Nov-Dec;19(6):315-22. (PMID: 17343016)
المشرفين على المادة: 0 (Antibodies, Viral)
0 (RNA, Viral)
تواريخ الأحداث: Date Created: 20201120 Date Completed: 20210120 Latest Revision: 20210120
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7678967
DOI: 10.1371/journal.pone.0241799
PMID: 33216743
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0241799