دورية أكاديمية
Positron annihilation localization by nanoscale magnetization.
| العنوان: | Positron annihilation localization by nanoscale magnetization. |
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| المؤلفون: | Gholami YH; Faculty of Science, School of Physics, The University of Sydney, Sydney, NSW, Australia. yaser.gholami@sydney.edu.au.; Sydney Vital Translational Cancer Research Centre, St Leonards, NSW, Australia. yaser.gholami@sydney.edu.au.; Bill Walsh Translational Cancer Research Laboratory, The Kolling Institute, Northern Sydney Local Health District, Sydney, Australia. yaser.gholami@sydney.edu.au., Yuan H; Gordon Center for Medical Imaging, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Wilks MQ; Gordon Center for Medical Imaging, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Josephson L; Gordon Center for Medical Imaging, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., El Fakhri G; Gordon Center for Medical Imaging, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Normandin MD; Gordon Center for Medical Imaging, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Kuncic Z; Faculty of Science, School of Physics, The University of Sydney, Sydney, NSW, Australia. zdenka.kuncic@sydney.edu.au.; Sydney Vital Translational Cancer Research Centre, St Leonards, NSW, Australia. zdenka.kuncic@sydney.edu.au.; The University of Sydney Nano Institute, Sydney, NSW, Australia. zdenka.kuncic@sydney.edu.au. |
| المصدر: | Scientific reports [Sci Rep] 2020 Nov 20; Vol. 10 (1), pp. 20262. Date of Electronic Publication: 2020 Nov 20. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
| مواضيع طبية MeSH: | Magnetic Resonance Imaging/*methods , Magnetite Nanoparticles/*chemistry , Positron-Emission Tomography/*methods, Humans |
| مستخلص: | In positron emission tomography (PET), the finite range over which positrons travel before annihilating with an electron places a fundamental physical limit on the spatial resolution of PET images. After annihilation, the photon pair detected by the PET instrumentation is emitted from a location that is different from the positron-emitting source, resulting in image blurring. Here, we report on the localization of positron range, and hence annihilation quanta, by strong nanoscale magnetization of superparamagnetic iron oxide nanoparticles (SPIONs) in PET-MRI. We found that positron annihilations localize within a region of interest by up to 60% more when SPIONs are present (with [Fe] = 3 mM) compared to when they are not. The resulting full width at half maximum of the PET scans showed the spatial resolution improved by up to [Formula: see text] 30%. We also found evidence suggesting that the radiolabeled SPIONs produced up to a six-fold increase in ortho-positronium. These results may also have implications for emerging cancer theranostic strategies, where charged particles are used as therapeutic as well as diagnostic agents and improved dose localization within a tumor is a determinant of better treatment outcomes. |
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| معلومات مُعتمدة: | P41 EB022544 United States EB NIBIB NIH HHS |
| المشرفين على المادة: | 0 (Magnetite Nanoparticles) |
| تواريخ الأحداث: | Date Created: 20201121 Date Completed: 20210414 Latest Revision: 20210507 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7680104 |
| DOI: | 10.1038/s41598-020-76980-9 |
| PMID: | 33219274 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2045-2322 |
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| DOI: | 10.1038/s41598-020-76980-9 |