دورية أكاديمية
Positron annihilation localization by nanoscale magnetization.
العنوان: | Positron annihilation localization by nanoscale magnetization. |
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المؤلفون: | Gholami YH; Faculty of Science, School of Physics, The University of Sydney, Sydney, NSW, Australia. yaser.gholami@sydney.edu.au.; Sydney Vital Translational Cancer Research Centre, St Leonards, NSW, Australia. yaser.gholami@sydney.edu.au.; Bill Walsh Translational Cancer Research Laboratory, The Kolling Institute, Northern Sydney Local Health District, Sydney, Australia. yaser.gholami@sydney.edu.au., Yuan H; Gordon Center for Medical Imaging, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Wilks MQ; Gordon Center for Medical Imaging, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Josephson L; Gordon Center for Medical Imaging, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., El Fakhri G; Gordon Center for Medical Imaging, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Normandin MD; Gordon Center for Medical Imaging, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA., Kuncic Z; Faculty of Science, School of Physics, The University of Sydney, Sydney, NSW, Australia. zdenka.kuncic@sydney.edu.au.; Sydney Vital Translational Cancer Research Centre, St Leonards, NSW, Australia. zdenka.kuncic@sydney.edu.au.; The University of Sydney Nano Institute, Sydney, NSW, Australia. zdenka.kuncic@sydney.edu.au. |
المصدر: | Scientific reports [Sci Rep] 2020 Nov 20; Vol. 10 (1), pp. 20262. Date of Electronic Publication: 2020 Nov 20. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
مواضيع طبية MeSH: | Magnetic Resonance Imaging/*methods , Magnetite Nanoparticles/*chemistry , Positron-Emission Tomography/*methods, Humans |
مستخلص: | In positron emission tomography (PET), the finite range over which positrons travel before annihilating with an electron places a fundamental physical limit on the spatial resolution of PET images. After annihilation, the photon pair detected by the PET instrumentation is emitted from a location that is different from the positron-emitting source, resulting in image blurring. Here, we report on the localization of positron range, and hence annihilation quanta, by strong nanoscale magnetization of superparamagnetic iron oxide nanoparticles (SPIONs) in PET-MRI. We found that positron annihilations localize within a region of interest by up to 60% more when SPIONs are present (with [Fe] = 3 mM) compared to when they are not. The resulting full width at half maximum of the PET scans showed the spatial resolution improved by up to [Formula: see text] 30%. We also found evidence suggesting that the radiolabeled SPIONs produced up to a six-fold increase in ortho-positronium. These results may also have implications for emerging cancer theranostic strategies, where charged particles are used as therapeutic as well as diagnostic agents and improved dose localization within a tumor is a determinant of better treatment outcomes. |
References: | IEEE Nucl Sci Symp Conf Rec (1997). 2014 Nov;2014:. (PMID: 27076778) EJNMMI Phys. 2020 Jun 30;7(1):44. (PMID: 32607664) Q J Nucl Med Mol Imaging. 2008 Jun;52(2):151-8. (PMID: 18043539) Phys Med Biol. 2020 Jun 18;65(12):125013. (PMID: 32348968) ACS Nano. 2012 Aug 28;6(8):6821-8. (PMID: 22762250) Nanotechnology. 2019 Mar 15;30(11):112001. (PMID: 30609414) Philos Trans A Math Phys Eng Sci. 2010 Sep 28;368(1927):4419-37. (PMID: 20732895) J Nucl Med. 2018 Jan;59(1):3-12. (PMID: 28935835) J Nucl Med. 2015 Jun;56(6):951-4. (PMID: 25766897) Nat Protoc. 2018 Feb;13(2):392-412. (PMID: 29370158) Nat Rev Cancer. 2002 Sep;2(9):683-93. (PMID: 12209157) Med Phys. 2004 Jan;31(1):57-61. (PMID: 14761021) Phys Med Biol. 2005 Dec 7;50(23):5679-95. (PMID: 16306661) AJR Am J Roentgenol. 2015 Jul;205(1):64-9. (PMID: 26102381) Phys Med Biol. 2006 Apr 7;51(7):1707-23. (PMID: 16552099) Eur Phys J C Part Fields. 2016;76:445. (PMID: 27547122) Nucl Instrum Methods Phys Res A. 2011 Aug 21;648 Supplement 1:S236-S240. (PMID: 21804677) Cancer Biother Radiopharm. 2002 Feb;17(1):83-99. (PMID: 11915176) Eur J Radiol. 2012 Nov;81(11):3363-70. (PMID: 22613508) Sci Rep. 2018 Jun 27;8(1):9764. (PMID: 29950606) Front Chem. 2014 Jul 15;2:48. (PMID: 25077142) Phys Med Biol. 2014 Dec 7;59(23):7419-34. (PMID: 25386999) Nat Biotechnol. 2002 Aug;20(8):816-20. (PMID: 12134166) J Nucl Med. 2005 Jan;46 Suppl 1:4S-12S. (PMID: 15653646) Int J Nanomedicine. 2020 Feb 24;15:1253-1266. (PMID: 32161456) Phys Med Biol. 1999 Mar;44(3):781-99. (PMID: 10211810) J Nucl Med. 2004 Jul;45(7):1168-71. (PMID: 15235063) Int J Nanomedicine. 2020 Jan 07;15:31-47. (PMID: 32021163) Nat Commun. 2017 Sep 25;8(1):689. (PMID: 28947803) J Nucl Med. 2010 Jul;51(7):1049-58. (PMID: 20554737) Med Phys. 2015 Mar;42(3):1398-410. (PMID: 25735294) Sci Rep. 2015 Aug 06;5:12674. (PMID: 26246002) Nat Med. 2004 Jul;10 Suppl:S34-41. (PMID: 15298007) Phys Med Biol. 2015 Jan 7;60(1):117-36. (PMID: 25479147) |
معلومات مُعتمدة: | P41 EB022544 United States EB NIBIB NIH HHS |
المشرفين على المادة: | 0 (Magnetite Nanoparticles) |
تواريخ الأحداث: | Date Created: 20201121 Date Completed: 20210414 Latest Revision: 20210507 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC7680104 |
DOI: | 10.1038/s41598-020-76980-9 |
PMID: | 33219274 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2045-2322 |
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DOI: | 10.1038/s41598-020-76980-9 |