دورية أكاديمية
Folic acid prevents habituation memory impairment and oxidative stress in an aging model induced by D-galactose.
العنوان: | Folic acid prevents habituation memory impairment and oxidative stress in an aging model induced by D-galactose. |
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المؤلفون: | Garcez ML; Department of Biochemistry, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil., Cassoma RCS; Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, 88806-000, Brazil., Mina F; Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, 88806-000, Brazil., Bellettini-Santos T; Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, 88806-000, Brazil., da Luz AP; Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, 88806-000, Brazil., Schiavo GL; Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, 88806-000, Brazil., Medeiros EB; Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, 88806-000, Brazil., Campos ACBF; Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, 88806-000, Brazil., da Silva S; Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, 88806-000, Brazil., Rempel LCT; Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, 88806-000, Brazil., Steckert AV; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina, Criciúma, SC, Brazil., Barichello T; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina, Criciúma, SC, Brazil.; Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.; Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.; Neuroscience Graduate Program, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX, USA., Budni J; Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, 88806-000, Brazil. josiane.budni@unesc.net. |
المصدر: | Metabolic brain disease [Metab Brain Dis] 2021 Feb; Vol. 36 (2), pp. 213-224. Date of Electronic Publication: 2020 Nov 21. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 8610370 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7365 (Electronic) Linking ISSN: 08857490 NLM ISO Abbreviation: Metab Brain Dis Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2005- : Amsterdam : Springer Original Publication: New York : Plenum, c1986- |
مواضيع طبية MeSH: | Aging/*metabolism , Folic Acid/*pharmacology , Habituation, Psychophysiologic/*drug effects , Memory Disorders/*prevention & control , Oxidative Stress/*drug effects, Animals ; Galactose ; Hippocampus/drug effects ; Hippocampus/metabolism ; Male ; Memory/drug effects ; Memory Disorders/chemically induced ; Memory Disorders/metabolism ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/metabolism ; Rats ; Rats, Wistar |
مستخلص: | The present study aimed to evaluate the effect of folic acid treatment in an animal model of aging induced by D-galactose (D-gal). For this propose, adult male Wistar rats received D-gal intraperitoneally (100 mg/kg) and/or folic acid orally (5 mg/kg, 10 mg/kg or 50 mg/kg) for 8 weeks. D-gal caused habituation memory impairment, and folic acid (10 mg/kg and 50 mg/kg) reversed this effect. However, folic acid 50 mg/kg per se caused habituation memory impairment. D-gal increased the lipid peroxidation and oxidative damage to proteins in the prefrontal cortex and hippocampus from rats. Folic acid (5 mg/kg, 10 mg/kg, or 50 mg/kg) partially reversed the oxidative damage to lipids in the hippocampus, but not in the prefrontal cortex, and reversed protein oxidative damage in the prefrontal cortex and hippocampus. D-gal induced synaptophysin and BCL-2 decrease in the hippocampus and phosphorylated tau increase in the prefrontal cortex. Folic acid was able to reverse these D-gal-related alterations in the protein content. The present study shows folic acid supplementation as an alternative during the aging to prevent cognitive impairment and brain alterations that can cause neurodegenerative diseases. However, additional studies are necessary to elucidate the effect of folic acid in aging. |
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معلومات مُعتمدة: | RF1 AG072491 United States AG NIA NIH HHS |
فهرسة مساهمة: | Keywords: Aging; Cognitive impairment; D-galactose; Folic acid; Oxidative damage; Rats |
المشرفين على المادة: | 935E97BOY8 (Folic Acid) X2RN3Q8DNE (Galactose) |
تواريخ الأحداث: | Date Created: 20201121 Date Completed: 20211005 Latest Revision: 20240308 |
رمز التحديث: | 20240308 |
DOI: | 10.1007/s11011-020-00647-7 |
PMID: | 33219893 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1573-7365 |
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DOI: | 10.1007/s11011-020-00647-7 |