دورية أكاديمية

The impact of chronic kidney disease on long-term outcomes following semi-urgent and elective percutaneous coronary intervention.

التفاصيل البيبلوغرافية
العنوان: The impact of chronic kidney disease on long-term outcomes following semi-urgent and elective percutaneous coronary intervention.
المؤلفون: Soh RY; Internal Medicine Residency, National University Health System., Sia CH; Department of Cardiology, National University Heart Centre.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore., Lau RH; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore., Ho PY; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore., Timothy NY; National University Health System, University Medicine Cluster, Singapore, Singapore., Ho JS; School of Clinical Medicine, University of Cambridge, Cambridge, UK., Kaur H; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore., Sim HW; Department of Cardiology, National University Heart Centre., Yeo TC; Department of Cardiology, National University Heart Centre.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore., Tan HC; Department of Cardiology, National University Heart Centre., Chan MY; Department of Cardiology, National University Heart Centre.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore., Loh JP; Department of Cardiology, National University Heart Centre.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore.
المصدر: Coronary artery disease [Coron Artery Dis] 2021 Sep 01; Vol. 32 (6), pp. 517-525.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 9011445 Publication Model: Print Cited Medium: Internet ISSN: 1473-5830 (Electronic) Linking ISSN: 09546928 NLM ISO Abbreviation: Coron Artery Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: London : Lippincott Williams & Wilkins
Original Publication: Philadelphia, Pa. : Current Science, c1990-
مواضيع طبية MeSH: Percutaneous Coronary Intervention*, Coronary Artery Disease/*surgery , Renal Insufficiency, Chronic/*complications, Aged ; Coronary Artery Disease/mortality ; Female ; Glomerular Filtration Rate ; Humans ; Male ; Middle Aged ; Renal Insufficiency, Chronic/mortality ; Renal Insufficiency, Chronic/therapy ; Retrospective Studies ; Risk Factors
مستخلص: Introduction: The effects of chronic kidney disease (CKD) on outcomes in patients undergoing semi-urgent and elective percutaneous coronary intervention (PCI) are unclear. This study aims to investigate impact of CKD on long-term outcomes of this population.
Methods: This was a retrospective cohort study of patients who underwent semi-urgent and elective PCI from 1 January 2014 to 31 December 2015 at a tertiary academic center. They were stratified into five groups - group 1 [estimated glomerular filtration rate (eGFR) ≥90 ml/min/1.73m2], group 2 (eGFR 60-89 ml/min/1.73m2), group 3 (eGFR 30-59 ml/min/1.73 m2), group 4 (eGFR <30 ml/min/1.73m2), and group 5 (dialysis). Demographics, risk factors in relation to endpoints of all-cause mortality, contrast-induced nephropathy (CIN), three-point major adverse cardiac events (MACE) (cardiac death, subsequent myocardial infarction, subsequent stroke), and four-point MACE (including target lesion revascularization) were analyzed.
Results: One thousand six hundred nine patients were included. Advanced CKD patients were more likely to be female and older, with higher prevalence of co-morbidities. Compared to group 1, group 4 patients were associated with increased risk of three-point [adjusted hazard ratio (aHR) 1.94, 95% confidence interval (CI): 1.06-3.55; P = 0.031] and four-point MACE (aHR 2.15, 95% CI: 1.21-3.80; P = 0.009). However, higher contrast volume usage [odds ratio (OR) 2.20, 95% CI: 1.04-4.68; P = 0.040) was associated with increased CIN risk but not reduced eGFR (OR 1.62, 95% CI: 0.57-4.65; P = 0.369).
Conclusion: Advanced CKD patients undergoing PCI were associated with higher co-morbid burden. Despite adjustments for co-morbidities, these patients had higher mortality and worse cardiovascular outcomes at 3 years following contemporary PCI.
(Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.)
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تواريخ الأحداث: Date Created: 20201124 Date Completed: 20220124 Latest Revision: 20220124
رمز التحديث: 20221213
DOI: 10.1097/MCA.0000000000000980
PMID: 33229937
قاعدة البيانات: MEDLINE
الوصف
تدمد:1473-5830
DOI:10.1097/MCA.0000000000000980