دورية أكاديمية
Outcomes and predictors of juvenile idiopathic arthritis in Southeast Asia: a Singapore longitudinal study over a decade.
| العنوان: | Outcomes and predictors of juvenile idiopathic arthritis in Southeast Asia: a Singapore longitudinal study over a decade. |
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| المؤلفون: | Teh KL; Rheumatology and Immunology Service, Department of Pediatric Subspecialties, KK Women's and Children's Hospital, 100 Bukit Timah Road, Children's Tower, Level 3, zone B, Singapore, 229899, Singapore., Tanya M; Rheumatology and Immunology Service, Department of Pediatric Subspecialties, KK Women's and Children's Hospital, 100 Bukit Timah Road, Children's Tower, Level 3, zone B, Singapore, 229899, Singapore., Das L; Rheumatology and Immunology Service, Department of Pediatric Subspecialties, KK Women's and Children's Hospital, 100 Bukit Timah Road, Children's Tower, Level 3, zone B, Singapore, 229899, Singapore., Hoh SF; Division of Nursing, KK Women's and Children's Hospital, Singapore, Singapore., Gao X; Division of Nursing, KK Women's and Children's Hospital, Singapore, Singapore., Arkachaisri T; Rheumatology and Immunology Service, Department of Pediatric Subspecialties, KK Women's and Children's Hospital, 100 Bukit Timah Road, Children's Tower, Level 3, zone B, Singapore, 229899, Singapore. thaschawee.arkachaisri@singhealth.com.sg.; Duke-NUS Medical School, Singapore, Singapore. thaschawee.arkachaisri@singhealth.com.sg. |
| المصدر: | Clinical rheumatology [Clin Rheumatol] 2021 Jun; Vol. 40 (6), pp. 2339-2349. Date of Electronic Publication: 2020 Nov 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Germany NLM ID: 8211469 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1434-9949 (Electronic) Linking ISSN: 07703198 NLM ISO Abbreviation: Clin Rheumatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2008->: Heidelberg : Springer Original Publication: Brussels : Acta Medica Belgica, [1982- |
| مواضيع طبية MeSH: | Antirheumatic Agents*/therapeutic use , Arthritis, Juvenile*/drug therapy , Arthritis, Juvenile*/epidemiology, Child ; Female ; Humans ; Longitudinal Studies ; Male ; Singapore/epidemiology ; Treatment Outcome ; Young Adult |
| مستخلص: | Objective: To assess short- and long-term outcomes and predictors of juvenile idiopathic arthritis (JIA) children treated with contemporary therapy and compare those with reports elsewhere. Methods: Children with JIA were recruited from our web-based REgistry for Childhood Onset Rheumatic Diseases (RECORD) from 1997 to 2015. Disease status was defined using modified Wallace criteria. Nonparametric statistics described the data. Kaplan-Meier survival and logistic regression analyses were used to estimate probabilities and to determine predictors of outcomes. Results: A total of 251 children with JIA (62% males, 71% Chinese) were included. Median follow-up duration was 2.9 years (range 0.1-17.5). Short-term clinical inactive disease (CID) was attained in 37% with 62% systemic JIA (sJIA) and 47% persistent oligoarthritis (oJIA). Methotrexate (OR 0.34) decreased but sJIA (OR 3.25) increased chance of attaining CID at 6 months. Overall, 79% of patients achieved CID within 2 years (sJIA 92%, the highest, and RF+ polyarthritis 50%, the lowest probability). Biologics were associated with CID attainment (OR 2.73). One-half of patients flare after CID, median 1.2 years (IQR 0.71-1.97). Late CID achievement predicted flare (OR 2.15). Only 15% had clinical remission off medication (none RF+ polyarthritis and 7% ERA). Only 13% of patients had active arthritis as young adults and 22% had active arthritis at last visit. Conclusion: Despite high proportion of JIA patients attaining CID, only one-fourth could stop all medications for at least 1 year. Persistent oJIA patients were less likely to achieve clinical remission on medication and ERA patients had the least chance stopping medications. One-tenth of patients had active arthritis as young adults. Key Points • Majority of Asian children with JIA attained inactive disease within 2 years after diagnosis. • Outcome predictors were different from reports from the West. • Despite high inactive disease numbers, only one-in-four JIA patients discontinued treatment within 5 years. |
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| معلومات مُعتمدة: | ILAR 2011 The International Leagues of Associations for Rheumatology; NAF 2011 The National Arthritis Foundation of Singapore |
| فهرسة مساهمة: | Keywords: Juvenile idiopathic arthritis; Outcomes; Predictors; Singapore; Southeast Asia; Treatment |
| المشرفين على المادة: | 0 (Antirheumatic Agents) |
| تواريخ الأحداث: | Date Created: 20201125 Date Completed: 20210518 Latest Revision: 20210518 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s10067-020-05520-7 |
| PMID: | 33236179 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1434-9949 |
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| DOI: | 10.1007/s10067-020-05520-7 |