دورية أكاديمية
Significance of Intracellular Adhesion Molecule-1 Polymorphism and IP-10 among Breast Cancer Patients.
| العنوان: | Significance of Intracellular Adhesion Molecule-1 Polymorphism and IP-10 among Breast Cancer Patients. |
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| المؤلفون: | Ghazy AA; Department of Pathology (Microbiology & Immunology unit), College of Medicine, Jouf University, Saudi Arabia.; Microbiology & Immunology Department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt., Elsheredy HG; Department of Cancer management and research, Medical Research Institute, Alexandria University, Alexandria, Egypt., Abouelella AM; Radiation Biology Department, National Centre for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt., Rashwan EK; Department of Physiology, College of Medicine, Jouf University, Saudi Arabia.; Department of Physiology, Faculty of Medicine, Al-Azhar University, Assuit, Egypt., Khaled BEA; Anatomy Department, College of Medicine, Jouf University, Saudi Arabia.; Anatomy Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Elsheredy AG; Department of Microbiology, Medical Research Institute, Alexandria University, Alexandria, Egyp. |
| المصدر: | The Egyptian journal of immunology [Egypt J Immunol] 2020 Jan; Vol. 27 (1), pp. 187-195. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Modern Commercial Press Country of Publication: Egypt NLM ID: 9816016 Publication Model: Print Cited Medium: Print ISSN: 1110-4902 (Print) NLM ISO Abbreviation: Egypt J Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cairo : Modern Commercial Press, |
| مواضيع طبية MeSH: | Breast Neoplasms*/genetics , Chemokine CXCL10*/genetics, Intercellular Adhesion Molecule-1/*genetics, Alleles ; Case-Control Studies ; Egypt ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Polymorphism, Single Nucleotide |
| مستخلص: | Breast cancer (BC) is the second leading cause of women's death worldwide. Intercellular adhesion molecule-1 (ICAM-1) is involved in cell-cell interaction, migration and recruitment of immune cells. Polymorphisms in ICAM-1 gene may be involved in BC progression. IFN-gamma inducible protein-10 (IP-10) has the ability to recruit T-cells to induce cellular immunity and may have protective effect against BC development. The current study aimed to shed light on the role of of ICAM-1 SNP and/or serum levels of IP10 in BC in Egyptian female patients and detect possible correlation between these two factors and pathological prognostic markers. 40 breast cancer patients and 40 healthy females were enrolled in the study. Genotyping of ICAM-1 rs281437 SNP was done using real time PCR and serum levels of IP-10 were measured using ELISA. Allelic distribution demonstrated high frequency of ICAM-1 rs281437 CC genotype among BC patients (60%) compared to CT and TT alleles (30% and 10%, respectively). ICAM-1 rs281437 CC genotype showed 9.8 folds more risk to develop BC than other genotypes (95% CI=5.8-21.8, P<0.05). Relation between the studied alleles and hormonal receptors (ER, PR) showed that both ICAM-1 rs281437 CC and CT genotype have 5 folds more to be ER+, PR+ BC compared to TT allele (95% CI=0.21-117.8 and 0.15-125.4, respectively). Serum IP-10 levels were markedly decreased among breast cancer patients when compared with healthy controls (P = 0.001). In conclusion, ICAM-1 rs281437 CC genotype is significantly associated with breast cancer; females carrying CC allele may be at higher risk to develop BC than those carrying CT or TT genotypes. On the other hand, IP-10 may have a protective effect against breast cancer. (Copyright© by the Egyptian Association of Immunologists.) |
| المشرفين على المادة: | 0 (CXCL10 protein, human) 0 (Chemokine CXCL10) 0 (ICAM1 protein, human) 126547-89-5 (Intercellular Adhesion Molecule-1) |
| تواريخ الأحداث: | Date Created: 20201125 Date Completed: 20210114 Latest Revision: 20210114 |
| رمز التحديث: | 20231215 |
| PMID: | 33236621 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1110-4902 |
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