دورية أكاديمية
Yeast Nup84-Nup133 complex structure details flexibility and reveals conservation of the membrane anchoring ALPS motif.
العنوان: | Yeast Nup84-Nup133 complex structure details flexibility and reveals conservation of the membrane anchoring ALPS motif. |
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المؤلفون: | Nordeen SA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Turman DL; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Schwartz TU; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. tus@mit.edu. |
المصدر: | Nature communications [Nat Commun] 2020 Nov 27; Vol. 11 (1), pp. 6060. Date of Electronic Publication: 2020 Nov 27. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [London] : Nature Pub. Group |
مواضيع طبية MeSH: | Conserved Sequence*, Cell Membrane/*metabolism , Nuclear Pore Complex Proteins/*chemistry , Saccharomyces cerevisiae/*metabolism , Saccharomyces cerevisiae Proteins/*chemistry, Amino Acid Motifs ; Humans ; Models, Molecular ; Nuclear Pore Complex Proteins/metabolism ; Protein Domains ; Saccharomyces cerevisiae Proteins/metabolism ; Sequence Homology, Amino Acid |
مستخلص: | The hallmark of the eukaryotic cell is the complex endomembrane system that compartmentalizes cellular functions. Transport into and out of the nucleus occurs through the nuclear pore complex (NPC). The heptameric Nup84 or Y complex is an essential scaffolding component of the NPC. Here we report two nanobody-bound structures: the full-length Nup84-Nup133 C-terminal domain complex and the Nup133 N-terminal domain, both from S. cerevisiae. Together with previously published structures, this work enables the structural description of the entire 575 kDa Y complex from one species. The structure of Nup84-Nup133 |
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معلومات مُعتمدة: | T32 GM007287 United States GM NIGMS NIH HHS |
المشرفين على المادة: | 0 (NUP133 protein, S cerevisiae) 0 (NUP84 protein, S cerevisiae) 0 (Nuclear Pore Complex Proteins) 0 (Saccharomyces cerevisiae Proteins) |
تواريخ الأحداث: | Date Created: 20201128 Date Completed: 20201209 Latest Revision: 20230106 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC7695694 |
DOI: | 10.1038/s41467-020-19885-5 |
PMID: | 33247142 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2041-1723 |
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DOI: | 10.1038/s41467-020-19885-5 |