دورية أكاديمية
Plasma angiotensin II levels in women with severe preeclampsia under magnesium sulfate regimen.
| العنوان: | Plasma angiotensin II levels in women with severe preeclampsia under magnesium sulfate regimen. |
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| المؤلفون: | de Lima ASD; Maternidade Escola Januário Cicco, Federal University of Rio Grande do Norte, Brazil., Holanda IP; Department of Biochemistry, Federal University of Rio Grande do Norte, Brazil., Nascimento PRP; Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Brazil., Jeronimo SMB; Department of Biochemistry, Federal University of Rio Grande do Norte, Brazil; Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Brazil; National Institute of Science and Technology of Tropical Diseases, Brazil., Ferreira LC; Department of Biochemistry, Federal University of Rio Grande do Norte, Brazil; Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Brazil. Electronic address: ferreiralc@cb.ufrn.br. |
| المصدر: | Pregnancy hypertension [Pregnancy Hypertens] 2021 Mar; Vol. 23, pp. 56-58. Date of Electronic Publication: 2020 Nov 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101552483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2210-7797 (Electronic) Linking ISSN: 22107789 NLM ISO Abbreviation: Pregnancy Hypertens Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amtserdam : Elsevier |
| مواضيع طبية MeSH: | Angiotensin II/*drug effects , Magnesium Sulfate/*pharmacology , Pre-Eclampsia/*drug therapy, Age Factors ; Angiotensin II/blood ; Case-Control Studies ; Female ; Humans ; Magnesium Sulfate/administration & dosage ; Pre-Eclampsia/blood ; Pregnancy ; Seizures/prevention & control |
| مستخلص: | The role of Renin-Angiotensin-System (RAS) in the pathogenesis of preeclampsia and eclampsia is still unclear. Our aim was to investigate plasma angiotensin II concentration [Ang II] in women with normotensive pregnancies (NP, n = 22) and severe preeclampsia in use of magnesium sulfate (SPE, n = 29). Despite no difference between the groups (SPE: 47.8 pg/ml vs NP: 39.7 pg/ml, p = 0.195), lower maternal age (p = 0.007) and primigravida (p = 0.028) were associated with lower [Ang II]. Plasma [Ang II] increased over the 24 h of magnesium sulfate administration (r = 0.48, p = 0.009). Our findings suggest that RAS may be involved with the mechanism of magnesium protection against eclamptic seizure. (Copyright © 2020 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Angiotensin; Magnesium; Preeclampsia; Seizure |
| المشرفين على المادة: | 11128-99-7 (Angiotensin II) 7487-88-9 (Magnesium Sulfate) |
| تواريخ الأحداث: | Date Created: 20201129 Date Completed: 20210924 Latest Revision: 20210924 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.preghy.2020.11.003 |
| PMID: | 33249328 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2210-7797 |
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| DOI: | 10.1016/j.preghy.2020.11.003 |