دورية أكاديمية
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Behavioral and EEGraphic Characterization of the Anticonvulsant Effects of the Predator Odor (TMT) in the Amygdala Rapid Kindling, a Model of Temporal Lobe Epilepsy.

التفاصيل البيبلوغرافية
العنوان: Behavioral and EEGraphic Characterization of the Anticonvulsant Effects of the Predator Odor (TMT) in the Amygdala Rapid Kindling, a Model of Temporal Lobe Epilepsy.
المؤلفون: Delfino-Pereira P; Department of Neuroscience and Behavioral Sciences, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.; Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil., Bertti-Dutra P; Department of Neuroscience and Behavioral Sciences, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.; Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil., Del Vecchio F; Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil., de Oliveira JAC; Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil., Medeiros DC; Department of Physiology and Biophysics, Institute of Biological Science Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil.; Electrical Engineering Graduate Program, Federal University of Minas Gerais, Belo Horizonte, Brazil., Cestari DM; Department of Computer Science, Institute of Mathematics and Computer Sciences, University of São Paulo, São Carlos, Brazil., Santos VR; Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.; Department of Morphology, Institute of Biological Science Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil., Moraes MFD; Department of Physiology and Biophysics, Institute of Biological Science Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil., Rosa JLG; Department of Computer Science, Institute of Mathematics and Computer Sciences, University of São Paulo, São Carlos, Brazil., Mendes EMAM; Electrical Engineering Graduate Program, Federal University of Minas Gerais, Belo Horizonte, Brazil., Garcia-Cairasco N; Department of Neuroscience and Behavioral Sciences, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.; Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
المصدر: Frontiers in neurology [Front Neurol] 2020 Nov 05; Vol. 11, pp. 586724. Date of Electronic Publication: 2020 Nov 05 (Print Publication: 2020).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101546899 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2295 (Print) Linking ISSN: 16642295 NLM ISO Abbreviation: Front Neurol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation, 2010]-
مستخلص: Background: Clinical and experimental evidence indicates that olfactory stimulation modulates limbic seizures, either blocking or inducing ictal activity. Objective: We aim to evaluate the behavioral and electroencephalographic (EEGraphic) effects of dihydro-2,4,5-trimethylthiazoline (TMT) olfactory exposure on limbic seizures induced by amygdala rapid kindling (ARK). Materials and Methods: Wistar male rats (280-300 g) underwent stereotaxic surgery for electrode implantation in piriform cortex (PC), hippocampal formation (HIP), and amygdaloid complex (AMYG). Part of the animals was exposed to a saturated chamber with water or TMT, while others had ARK and olfactory exposure prior to the 21st stimulus. Behavioral responses were measured by traditional seizure severity scales (Racine and Pinel and Rovner) and/or by sequential analysis/neuroethology. The electrographic activity of epileptogenic limbic networks was quantified by the occurrence of the first and second EEG afterdischarges, comparing the 1st and 21st stimulus. The spectral analysis [Fast Fourier Transform (FFT)] of the first afterdischarge was performed at the 21st stimulus. Results: TMT olfactory exposure reduced the seizure severity in kindled rats, altering the displayed behavioral sequence. Moreover, TMT decreased the occurrence of first and second afterdischarges, at the 21st stimulus, and altered the spectral features. Conclusions: Both behavioral and EEGraphic evaluations indicated that TMT, a potent molecule with strong biological relevance, in fact, "predator odor," suppressed the epileptiform activity in limbic networks.
(Copyright © 2020 Delfino-Pereira, Bertti-Dutra, Del Vecchio, de Oliveira, Medeiros, Cestari, Santos, Moraes, Rosa, Mendes and Garcia-Cairasco.)
References: Nat Rev Neurosci. 2009 Jun;10(6):459-66. (PMID: 19339973)
Epilepsy Behav. 2016 Aug;61:90-96. (PMID: 27344500)
J Chem Ecol. 1984 Jul;10(7):1007-18. (PMID: 24318845)
Lancet Neurol. 2014 Sep;13(9):949-60. (PMID: 25127174)
Epilepsy Behav. 2017 Jun;71(Pt B):243-249. (PMID: 26440280)
Seizure. 2011 Jun;20(5):359-68. (PMID: 21292505)
Neuron. 2009 Sep 24;63(6):854-64. (PMID: 19778513)
J Neurosci. 2001 May 15;21(10):3619-27. (PMID: 11331391)
Exp Neurol. 1986 Nov;94(2):379-90. (PMID: 3095132)
Prog Neurobiol. 1980;15(2):139-59. (PMID: 6109361)
Neurosci Lett. 2005 Nov 4;388(1):33-8. (PMID: 16039062)
Brain Res. 2015 Mar 2;1599:1-8. (PMID: 25532494)
Behav Brain Res. 1992 May 8;48(1):49-56. (PMID: 1622553)
Epilepsy Behav. 2005 Dec;7(4):602-19. (PMID: 16169281)
Neurosci Biobehav Rev. 2004 Sep;28(5):507-24. (PMID: 15465138)
Front Neural Circuits. 2015 May 29;9:27. (PMID: 26074779)
Synapse. 2002 Oct;46(1):11-8. (PMID: 12211094)
Clin Neurol Neurosurg. 2008 Jun;110(6):535-8. (PMID: 18353533)
Neuroscience. 1995 May;66(2):265-76. (PMID: 7477871)
Neurology. 2014 Nov 18;83(21):1968-77. (PMID: 25339211)
J Neurol Sci. 2011 Sep 15;308(1-2):21-4. (PMID: 21762929)
Nat Commun. 2018 Apr 18;9(1):1528. (PMID: 29670106)
Nat Rev Drug Discov. 2013 Oct;12(10):757-76. (PMID: 24052047)
Biochem Pharmacol. 1996 Nov 8;52(9):1323-9. (PMID: 8937441)
Epilepsy Behav. 2018 Feb;79:213-224. (PMID: 29346088)
Med Hypotheses. 2010 Jan;74(1):24-6. (PMID: 19762161)
Brain Res. 1997 Aug 22;766(1-2):39-49. (PMID: 9359585)
Can J Neurol Sci. 2000 May;27 Suppl 1:S6-10; discussion S20-1. (PMID: 10830320)
Nat Rev Neurosci. 2005 Jun;6(6):463-75. (PMID: 15891777)
Seizure. 2003 Dec;12(8):534-8. (PMID: 14630489)
Epilepsia. 1989;30 Suppl 1:S13-8; discussion S64-8. (PMID: 2776709)
Mol Psychiatry. 2007 Dec;12(12):1103-17. (PMID: 17505467)
Nat Rev Neurosci. 2016 Jan;17(1):45-59. (PMID: 26675822)
Brain Res. 1985 Dec 23;360(1-2):83-91. (PMID: 3000538)
Epilepsia. 1975 Sep;16(3):457-61. (PMID: 1183420)
Prog Neurobiol. 1996 Dec;50(5-6):427-81. (PMID: 9015822)
Nature. 1967 Jun 3;214(5092):1020-1. (PMID: 6055396)
Exp Neurol. 1969 Nov;25(3):295-330. (PMID: 4981856)
Behav Processes. 2012 Jun;90(2):161-6. (PMID: 22248569)
J Pharmacol Exp Ther. 1984 Aug;230(2):407-12. (PMID: 6431079)
Brain Res. 2004 Oct 29;1025(1-2):139-51. (PMID: 15464754)
Epilepsy Res. 2015 Nov;117:90-6. (PMID: 26432759)
Epilepsia. 2007;48 Suppl 2:65-74. (PMID: 17571354)
Compr Physiol. 2015 Jan;5(1):1-15. (PMID: 25589262)
Epilepsy Res. 2008 May;79(2-3):166-72. (PMID: 18378119)
Brain Res. 2000 May 2;864(1):146-51. (PMID: 10793199)
J Neurosci. 1994 Jun;14(6):3413-25. (PMID: 8207463)
Neurosci Lett. 1995 May 12;190(3):199-202. (PMID: 7637892)
Neuropharmacology. 2012 Mar;62(4):1737-45. (PMID: 22210331)
Epilepsy Behav. 2005 May;6(3):328-36. (PMID: 15820339)
Front Behav Neurosci. 2010 Dec 23;4:188. (PMID: 21206761)
Epilepsia. 1995 Jun;36(6):531-42. (PMID: 7555965)
Front Behav Neurosci. 2014 Mar 11;8:72. (PMID: 24653685)
Nat Neurosci. 2015 Oct;18(10):1446-54. (PMID: 26322927)
Electroencephalogr Clin Neurophysiol. 1990 Nov;76(5):459-72. (PMID: 1699739)
Pharmacol Rev. 2010 Dec;62(4):668-700. (PMID: 21079040)
Med Hypotheses. 2010 Jan;74(1):210. (PMID: 19656637)
J Neurosci. 2003 Apr 1;23(7):2759-68. (PMID: 12684462)
Epilepsia. 2008 Jul;49(7):1230-8. (PMID: 18363709)
Epilepsia. 2005 Apr;46(4):470-2. (PMID: 15816939)
Nature. 1999 Jun 24;399(6738 Suppl):A15-22. (PMID: 10392576)
Nat Rev Drug Discov. 2010 Jan;9(1):68-82. (PMID: 20043029)
Neurosci Biobehav Rev. 2008 Sep;32(7):1259-66. (PMID: 18579206)
Front Integr Neurosci. 2011 Oct 03;5:49. (PMID: 22102836)
Behav Brain Res. 2010 Dec 25;214(2):317-22. (PMID: 20595033)
Brain Res. 1997 Oct 3;770(1-2):221-7. (PMID: 9372222)
Electroencephalogr Clin Neurophysiol. 1972 Mar;32(3):281-94. (PMID: 4110397)
Exp Neurol. 1978 Jan 15;58(2):190-202. (PMID: 618743)
Brain Res Brain Res Rev. 1989 Jul-Sep;14(3):245-78. (PMID: 2679941)
Epilepsy Behav. 2014 Sep;38:37-42. (PMID: 24113565)
PLoS One. 2012;7(7):e41899. (PMID: 22848650)
Stereotact Funct Neurosurg. 1989;52(1):26-41. (PMID: 2784007)
J Neurol. 2013 Apr;260(4):1004-8. (PMID: 23135292)
Brain. 1957 Jun;80(2):251-62. (PMID: 13446311)
Neuropsychiatr Dis Treat. 2014 Sep 09;10:1693-705. (PMID: 25228809)
Brain. 1956 Jun;79(2):267-81. (PMID: 13364083)
Neurosci Lett. 2017 Aug 24;656:144-151. (PMID: 28746840)
Epilepsy Res. 2002 Jun;50(1-2):105-23. (PMID: 12151122)
J Neurosci. 2003 Jan 1;23(1):23-8. (PMID: 12514197)
Clin EEG Neurosci. 2015 Jul;46(3):263-5. (PMID: 25013184)
Behav Brain Res. 2013 Feb 1;238:227-31. (PMID: 23089645)
Epilepsia. 2014 Apr;55(4):475-82. (PMID: 24730690)
Neurosci Lett. 2000 Jun 30;287(3):199-202. (PMID: 10863029)
Brain Res. 1987 Mar 31;407(2):212-22. (PMID: 3105818)
Sci Rep. 2013;3:1483. (PMID: 23514826)
Epilepsy Res. 2016 Oct;126:157-84. (PMID: 27505294)
Seizure. 2010 Jul;19(6):311-8. (PMID: 20493725)
فهرسة مساهمة: Keywords: 2,5-dihydro-2,4,5-trimethylthiazoline (TMT); amygdala rapid kindling (ARK); epilepsy; olfaction; seizures; temporal lobe epilepsy (TLE)
تواريخ الأحداث: Date Created: 20201130 Latest Revision: 20201201
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7674931
DOI: 10.3389/fneur.2020.586724
PMID: 33250852
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-2295
DOI:10.3389/fneur.2020.586724