دورية أكاديمية
Does antipsychotic combination therapy reduce the risk of hospitalization in schizophrenia?
| العنوان: | Does antipsychotic combination therapy reduce the risk of hospitalization in schizophrenia? |
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| المؤلفون: | Faden J; Department of Psychiatry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA., Kiryankova-Dalseth N; Department of Psychiatry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA., Barghini R; Department of Psychiatry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA., Citrome L; Department of Psychiatry & Behavioral Sciences, New York Medical College, Valhalla, NY, USA. |
| المصدر: | Expert opinion on pharmacotherapy [Expert Opin Pharmacother] 2021 Apr; Vol. 22 (5), pp. 635-646. Date of Electronic Publication: 2020 Nov 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 100897346 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-7666 (Electronic) Linking ISSN: 14656566 NLM ISO Abbreviation: Expert Opin Pharmacother Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: London : Ashley Publications, c1999- |
| مواضيع طبية MeSH: | Antipsychotic Agents*/adverse effects , Schizophrenia*/drug therapy, Drug Therapy, Combination ; Hospitalization ; Humans ; Retrospective Studies |
| مستخلص: | Introduction: : Despite treatment with antipsychotic medication, approximately 1/3 of individuals with schizophrenia will fail to have an adequate response. To treat these patients, a commonly utilized approach is antipsychotic combination therapy. Antipsychotic combination therapy is controversial with mixed efficacy and tolerability results. It is also unclear if antipsychotic combination therapy reduces or increases the risk of psychiatric hospitalization. Areas Covered: : The authors review the prevalence, efficacy and tolerability concerns, and rationale behind antipsychotic combination therapy. Evidence comparing antipsychotic monotherapy vs polypharmacy using hospitalization as an outcome measure is summarized. Expert Opinion: : Psychiatric rehospitalization is a useful measure of treatment effectiveness, incorporating aspects of treatment efficacy and tolerability. The evidence comparing the impact of antipsychotic monotherapy vs combination therapy on rehospitalization is mixed. Evidence is primarily retrospective in nature, and there is high heterogeneity between studies, which could partially explain the mixed results. There is likely a subset of patients for whom antipsychotic combination therapy reduces the risk of hospitalization greater than antipsychotic monotherapy. Patients should be treated individually taking into account their specific pattern of response. |
| فهرسة مساهمة: | Keywords: Antipsychotic combination therapy; antipsychotic monotherapy; antipsychotic polypharmacy; hospitalization; rehospitalization |
| المشرفين على المادة: | 0 (Antipsychotic Agents) |
| تواريخ الأحداث: | Date Created: 20201130 Date Completed: 20210427 Latest Revision: 20220421 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1080/14656566.2020.1847274 |
| PMID: | 33251870 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1744-7666 |
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| DOI: | 10.1080/14656566.2020.1847274 |