دورية أكاديمية
أعرض في EDS

Diagnostic Accuracy of Cross-Polarization OCT and OCT-Elastography for Differentiation of Breast Cancer Subtypes: Comparative Study.

التفاصيل البيبلوغرافية
العنوان: Diagnostic Accuracy of Cross-Polarization OCT and OCT-Elastography for Differentiation of Breast Cancer Subtypes: Comparative Study.
المؤلفون: Gubarkova EV; Institute of Experimental Oncology and Biomedical Technologies, Privolzhsky Research Medical University, 603950 Nizhny Novgorod, Russia., Kiseleva EB; Institute of Experimental Oncology and Biomedical Technologies, Privolzhsky Research Medical University, 603950 Nizhny Novgorod, Russia., Sirotkina MA; Institute of Experimental Oncology and Biomedical Technologies, Privolzhsky Research Medical University, 603950 Nizhny Novgorod, Russia., Vorontsov DA; Department of Oncology, Nizhny Novgorod Regional Oncologic Hospital, 603126 Nizhny Novgorod, Russia., Achkasova KA; Institute of Experimental Oncology and Biomedical Technologies, Privolzhsky Research Medical University, 603950 Nizhny Novgorod, Russia., Kuznetsov SS; Department of Pathology, Privolzhsky Research Medical University, 603950 Nizhny Novgorod, Russia., Yashin KS; University Clinic, Privolzhsky Research Medical University, 603950 Nizhny Novgorod, Russia., Matveyev AL; Laboratory of Multidimensional Signal Processing, Institute of Applied Physics of the Russian Academy of Sciences, 603950 Nizhny Novgorod, Russia., Sovetsky AA; Laboratory of Wave Methods for Studying Structurally Inhomogeneous Media, Institute of Applied Physics of the Russian Academy of Sciences, 603950 Nizhny Novgorod, Russia., Matveev LA; Laboratory of Wave Methods for Studying Structurally Inhomogeneous Media, Institute of Applied Physics of the Russian Academy of Sciences, 603950 Nizhny Novgorod, Russia., Plekhanov AA; Institute of Experimental Oncology and Biomedical Technologies, Privolzhsky Research Medical University, 603950 Nizhny Novgorod, Russia., Vorontsov AY; Department of Oncology, Nizhny Novgorod Regional Oncologic Hospital, 603126 Nizhny Novgorod, Russia., Zaitsev VY; Laboratory of Wave Methods for Studying Structurally Inhomogeneous Media, Institute of Applied Physics of the Russian Academy of Sciences, 603950 Nizhny Novgorod, Russia., Gladkova ND; Institute of Experimental Oncology and Biomedical Technologies, Privolzhsky Research Medical University, 603950 Nizhny Novgorod, Russia.
المصدر: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2020 Nov 24; Vol. 10 (12). Date of Electronic Publication: 2020 Nov 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101658402 Publication Model: Electronic Cited Medium: Print ISSN: 2075-4418 (Print) Linking ISSN: 20754418 NLM ISO Abbreviation: Diagnostics (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2011]-
مستخلص: The possibility to assess molecular-biological and morphological features of particular breast cancer types can improve the precision of resection margin detection and enable accurate determining of the tumor aggressiveness, which is important for treatment selection. To enable reliable differentiation of breast-cancer subtypes and evaluation of resection margin, without performing conventional histological procedures, here we apply cross-polarization optical coherence tomography (CP-OCT) and compare it with a novel variant of compressional optical coherence elastography (C-OCE) in terms of the diagnostic accuracy (Ac) with histological verification. The study used 70 excised breast cancer specimens with different morphological structure and molecular status (Luminal A, Luminal B, Her2/Neo+, non-luminal and triple-negative cancer). Our first aim was to formulate convenient criteria of visual assessment of CP-OCT and C-OCE images intended (i) to differentiate tumorous and non-tumorous tissues and (ii) to enable more precise differentiation among different malignant states. We identified such criteria based on the presence of heterogeneities and characteristics of signal attenuation in CP-OCT images, as well as the presence of inclusions/mosaic structures combined with visually feasible assessment of several stiffness grades in C-OCE images. Secondly, we performed a blinded reader study of the Ac of C-OCE versus CP-OCT, for delineation of tumorous versus non-tumorous tissues followed by identification of breast cancer subtypes. For tumor detection, C-OCE showed higher specificity than CP-OCT (97.5% versus 93.3%) and higher Ac (96.0 versus 92.4%). For the first time, the Ac of C-OCE and CP-OCT were evaluated for differentiation between non-invasive and invasive breast cancer (90.4% and 82.5%, respectively). Furthermore, for invasive cancers, the difference between invasive but low-aggressive and highly-aggressive subtypes can be detected. For differentiation between non-tumorous tissue and low-aggressive breast-cancer subtypes, Ac was 95.7% for C-OCE and 88.1% for CP-OCT. For differentiation between non-tumorous tissue and highly-aggressive breast cancers, Ac was found to be 98.3% for C-OCE and 97.2% for CP-OCT. In all cases C-OCE showed better diagnostic parameters independently of the tumor type. These findings confirm the high potential of OCT-based examinations for rapid and accurate diagnostics during breast conservation surgery.
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معلومات مُعتمدة: 18-75-10068 Russian Science Foundation
فهرسة مساهمة: Keywords: breast cancer; compressional optical coherence elastography (C-OCE); cross-polarization optical coherence tomography (CP-OCT); image assessment
تواريخ الأحداث: Date Created: 20201201 Latest Revision: 20201226
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7760404
DOI: 10.3390/diagnostics10120994
PMID: 33255263
قاعدة البيانات: MEDLINE
الوصف
تدمد:2075-4418
DOI:10.3390/diagnostics10120994