دورية أكاديمية
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Novel Solid Dispersions of Naphthoquinone Using Different Polymers for Improvement of Antichagasic Activity.

التفاصيل البيبلوغرافية
العنوان: Novel Solid Dispersions of Naphthoquinone Using Different Polymers for Improvement of Antichagasic Activity.
المؤلفون: Oliveira VDS; Department of Pharmacy, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte 59012-570, Brazil., Dantas ED; Department of Pharmacy, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte 59012-570, Brazil., Queiroz ATS; Department of Pharmacy, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte 59012-570, Brazil., Oliveira JWF; Department of Pharmacy, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte 59012-570, Brazil., Silva MSD; Department of Pharmacy, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte 59012-570, Brazil.; Global Health and Tropical Medicine, Institute of Hygiene and Tropical Medicine, NOVA University Lisbon, 1800-166 Lisbon, Portugal., Ferreira PG; Department of Pharmaceutical Technology, Faculty of Pharmacy, Federal Fluminense University, Niterói, Rio de Janeiro 24241-002, Brazil., Siva FCD; Institute of Chemistry, Federal University Fluminense, Niterói, Rio de Janeiro 24020-150, Brazil., Ferreira VF; Department of Pharmaceutical Technology, Faculty of Pharmacy, Federal Fluminense University, Niterói, Rio de Janeiro 24241-002, Brazil., Lima ÁAN; Department of Pharmacy, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte 59012-570, Brazil.
المصدر: Pharmaceutics [Pharmaceutics] 2020 Nov 24; Vol. 12 (12). Date of Electronic Publication: 2020 Nov 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مستخلص: IVS320 (3a,10b-dihydro-1 H -cyclopenta[ b ]naphtho[2,3- d ]furan-5,10-dione) is a naphthoquinone that has low solubility in aqueous medium, a physical behavior that limits its biological activities, considering that compounds from this class have several activities. In this work, solid dispersions (SDs) prepared between IVS320 and polymers hydroxypropyl methylcellulose (HPMC), polyethylene glycol (PEG), and polyvinylpyrrolidone (PVP) were developed using physical mixture (PM), kneading (KN), and rotary evaporation (RE) methods. Dispersions were investigated using Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetry (TG), powder X-ray diffraction (PXRD), and scanning electron microscopy (SEM). In addition, in vitro antiparasitic activity in Trypanosoma cruzi Y strains was evaluated. Physical-chemical characterization demonstrated the formation of SDs through the interaction of IVS320 with polymeric matrices. SDs of IVS320-polymer presented a significant potentiation of antichagasic activity, with inhibitory growth around 62% (IVS320-HPMC/RE), 55% (IVS320-PEG/RE), and 85% (IVS320-PVP/RE), while pure IVS320 showed a value of 48% for the highest concentrations evaluated (50 µg/mL).
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فهرسة مساهمة: Keywords: antichagasic activity; delivery system; polymeric carriers; solid dispersion
تواريخ الأحداث: Date Created: 20201201 Latest Revision: 20201226
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7760255
DOI: 10.3390/pharmaceutics12121136
PMID: 33255502
قاعدة البيانات: MEDLINE
الوصف
تدمد:1999-4923
DOI:10.3390/pharmaceutics12121136