Clinical, haematological and biochemical profiling of podoconiosis lymphoedema patients prior to their involvement in a clinical trial in the Northwest Region of Cameroon.

التفاصيل البيبلوغرافية
العنوان:	Clinical, haematological and biochemical profiling of podoconiosis lymphoedema patients prior to their involvement in a clinical trial in the Northwest Region of Cameroon.
المؤلفون:	Ndzeshang BL; Department of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.; Research Foundation in Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon., Mbiakop RT; Department of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.; Research Foundation in Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon., Nchanji GT; Department of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.; Research Foundation in Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon., Kien CA; Department of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.; Research Foundation in Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon., Amambo GN; Department of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.; Research Foundation in Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon., Abong RA; Department of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.; Research Foundation in Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon., Yuyun T; Regional Hospital Bamenda, P.O. Box 818, Bamenda Cameroon., Beng AA; Department of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.; Research Foundation in Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon., Bonekeh J; Research Foundation in Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon., Ritter M; Institute for Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn (UKB), Bonn, Germany., Esum ME; Department of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.; Research Foundation in Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon., Cho JF; Department of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.; Research Foundation in Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon., Njouendou AJ; Department of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.; Research Foundation in Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon., Ndifor IN; Ndop District Hospital, P.O. Box 07, Ndop, Cameroon., Deribe K; Global Health and Infection Department, Brighton and Sussex Medical School, Brighton, BN1 9PX, UK.; School of Public Health, Addis Ababa University, Ethiopia., Fombad FF; Department of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.; Research Foundation in Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon., Enyong P; Department of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.; Research Foundation in Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon., Klarmann-Schulz U; Institute for Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn (UKB), Bonn, Germany.; German Center for Infection Research (DZIF), partner-site Bonn-Cologne, Germany., Hoerauf A; Institute for Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn (UKB), Bonn, Germany.; German Center for Infection Research (DZIF), partner-site Bonn-Cologne, Germany., Wanji S; Department of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon.; Research Foundation in Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon.
المصدر:	Transactions of the Royal Society of Tropical Medicine and Hygiene [Trans R Soc Trop Med Hyg] 2020 Dec 16; Vol. 114 (12), pp. 954-961.
نوع المنشور:	Journal Article; Research Support, Non-U.S. Gov't
اللغة:	English
بيانات الدورية:	Publisher: Oxford University Press Country of Publication: England NLM ID: 7506129 Publication Model: Print Cited Medium: Internet ISSN: 1878-3503 (Electronic) Linking ISSN: 00359203 NLM ISO Abbreviation: Trans R Soc Trop Med Hyg Subsets: MEDLINE
أسماء مطبوعة:	Publication: 2013- : Oxford : Oxford University Press Original Publication: 1920- : London : Royal Society of Tropical Medicine and Hygiene
مواضيع طبية MeSH:	Elephantiasis/diagnosis , Elephantiasis/epidemiology , Lymphedema/epidemiology , Lymphedema/etiology, Cameroon/epidemiology ; Erythrocyte Indices ; Humans
مستخلص:	Background: Prior to carrying out clinical trials, it is important to assess the health status of the study participants to be able to interpret subsequent changes that may be related to the effects of the treatments during the follow-up of patients. This study presents the clinical, haematological and biochemical profiles of podoconiosis patients prior to their involvement in the PodoLEDoxy clinical trial. Methods: All lower limb lymphoedema patients visiting the centre were screened and a podoconiosis diagnosis was based on clinical manifestation and detailed medical history. Patients who satisfied the eligibility criteria were enrolled in the study and their demographic data, vital signs and medical history were collected followed by biochemical and haematological examinations. Results: Of the 222 participants enrolled in the study, 55.4% and 41.4% had either stage 3 or 2 podoconiosis as their highest stages, respectively. On physical examination, gastritis (46%) and poor vision (2.7%) were the most prevalent health issues identified. The majority of haematological and biochemical values were within the normal range except for mean platelet volume (47.7%), plateletcrit (58.1%), platelet distribution width (66.2%), mean corpuscular volume (67.6%) and red cell distribution width-standard deviation (79.3%), where >40% of the study participants had values out of the normal. Conclusion: The clinical, haematological and biochemical profiles of the study participants were largely within the normal range except for certain haematological parameters that might be worth investigating. (© The Author(s) 2020. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.)
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معلومات مُعتمدة:	201900/Z/16/Z United Kingdom WT_ Wellcome Trust
فهرسة مساهمة:	Keywords: biochemical; clinical; haematological; lymphodema; podoconiosis; profiling
تواريخ الأحداث:	Date Created: 20201201 Date Completed: 20210624 Latest Revision: 20220105
رمز التحديث:	20240628
مُعرف محوري في PubMed:	PMC7738657
DOI:	10.1093/trstmh/traa146
PMID:	33258944
قاعدة البيانات:	MEDLINE

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تدمد:	1878-3503
DOI:	10.1093/trstmh/traa146