دورية أكاديمية
Evaluation of a collagen matrix in a mandible defect in rats submitted to the use of bisphosphonates.
| العنوان: | Evaluation of a collagen matrix in a mandible defect in rats submitted to the use of bisphosphonates. |
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| المؤلفون: | Cunha VV; Fellow Master degree, Academic Master in Dental Sciences, School of Dentistry, Centro Universitário Christus (UNICHRISTUS), Fortaleza-CE, Brazil. Substantive scientific and intellectual contributions to the study., Silva PGB; Professor, Division of Oral and Maxillofacial Surgery, School of Dentistry, UNICHRISTUS, Fortaleza-CE, Brazil. Critical revision, final approval., Lemos JVM; Dentist, School of Dentistry, UNICHRISTUS, Fortaleza-CE, Brazil. Statistics analysis, manuscript preparation., Martins JOL; Dentist, School of Dentistry, UNICHRISTUS, Fortaleza-CE, Brazil. Manuscript preparation., Freitas MO; Dentist, School of Dentistry, UNICHRISTUS, Fortaleza-CE, Brazil. Acquisition, analysis and interpretation of data; technical procedures., Avelar RL; Professor, Division of Oral and Maxillofacial Surgery, School of Dentistry, UNICHRISTUS, Fortaleza-CE, Brazil. Critical revision, final approval. |
| المصدر: | Acta cirurgica brasileira [Acta Cir Bras] 2020 Nov 30; Vol. 35 (10), pp. e202001005. Date of Electronic Publication: 2020 Nov 30 (Print Publication: 2020). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sociedade Brasileira Para O Desenvolvimento Da Pesquisa Em Cirurgia Curso De Pos-Graduacao Em Tecnica Operatoria E Cirurgia Experimental Escola Paulista De Medicina Country of Publication: Brazil NLM ID: 9103983 Publication Model: eCollection Cited Medium: Internet ISSN: 1678-2674 (Electronic) Linking ISSN: 01028650 NLM ISO Abbreviation: Acta Cir Bras Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Sao Paulo : Sociedade Brasileira Para O Desenvolvimento Da Pesquisa Em Cirurgia Curso De Pos-Graduacao Em Tecnica Operatoria E Cirurgia Experimental Escola Paulista De Medicina Original Publication: São Paulo : A Sociedade, |
| مواضيع طبية MeSH: | Collagen* , Diphosphonates*, Animals ; Mandible ; Rats ; Rats, Wistar ; Zoledronic Acid |
| مستخلص: | Purpose: To assess the effect of a collagen matrix (Mucograft®) on the inflammatory process in a semi-critical experimental defect model in rats treated with bisphosphonates. Methods: Eighteen Wistar rats were randomly divided into three groups: saline (CG), alendronate (ALD) 5mg/kg (AG) or zoledronic acid (ZA) 0.2mg/kg (ZG). ALD was administered orally for 10 weeks and ZA was administered intravascularly on days 0, 7 and 14 and 49. On day 42, a 2mm defect was created and filled with Mucograft® collagen matrix. The contralateral side was filled with a clot (control side). The animals were euthanized 70 days after the beginning of the experiment and the hemimandibles were radiographically and histologically (counting of empty osteocyte lacunae (%), apoptotic (%) and total osteoclasts, neutrophil and mononuclear inflammatory cells) analyzed. The variables were submitted to ANOVA/Bonferroni and t test (parametric data) (p <0.05, GraphPad Prism 5.0). Results: Significant bone repair occurred in the groups treated with Mucograft®. High number of total inflammatory cells and neutrophils cells were showed in AG (p=0.026 and p=0.035) and AZ groups (p=0.005, p=0.034) on the control sides associated with delayed bone repair and the presence of devitalized bone tissue in AG and ZG on the Mucograft® side. Conclusion: Mucograft® collagen matrix attenuated the inflammatory process in a mandible defect in rats submitted to the use of bisphosphonates (AG and ZG). |
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| المشرفين على المادة: | 0 (Diphosphonates) 6XC1PAD3KF (Zoledronic Acid) 9007-34-5 (Collagen) |
| تواريخ الأحداث: | Date Created: 20201202 Date Completed: 20201204 Latest Revision: 20240804 |
| رمز التحديث: | 20240804 |
| مُعرف محوري في PubMed: | PMC7709902 |
| DOI: | 10.1590/s0102-865020200100000005 |
| PMID: | 33263607 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1678-2674 |
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| DOI: | 10.1590/s0102-865020200100000005 |