دورية أكاديمية
أعرض في EDS

Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of Aspergillus and Penicillium Genera.

التفاصيل البيبلوغرافية
العنوان: Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of Aspergillus and Penicillium Genera.
المؤلفون: Girich EV; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, Russia., Yurchenko AN; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, Russia., Smetanina OF; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, Russia., Trinh PTH; Department of Marine Biotechnology, Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang 650000, Vietnam., Ngoc NTD; Department of Marine Biotechnology, Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang 650000, Vietnam., Pivkin MV; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, Russia., Popov RS; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, Russia., Pislyagin EA; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, Russia., Menchinskaya ES; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, Russia., Chingizova EA; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, Russia., Afiyatullov SS; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, Russia., Yurchenko EA; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, Russia.
المصدر: Marine drugs [Mar Drugs] 2020 Nov 30; Vol. 18 (12). Date of Electronic Publication: 2020 Nov 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101213729 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-3397 (Electronic) Linking ISSN: 16603397 NLM ISO Abbreviation: Mar Drugs Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2003]-
مواضيع طبية MeSH: Antiparkinson Agents/*pharmacology , Aspergillus/*metabolism , Neurons/*drug effects , Neuroprotective Agents/*pharmacology , Parkinson Disease/*drug therapy , Penicillium/*metabolism, Animals ; Antiparkinson Agents/isolation & purification ; Cell Line, Tumor ; Cell Survival/drug effects ; Mice ; Molecular Structure ; Neurons/metabolism ; Neurons/pathology ; Neuroprotective Agents/isolation & purification ; Oxidative Stress/drug effects ; Paraquat/toxicity ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Reactive Oxygen Species/metabolism ; Rotenone/toxicity ; Secondary Metabolism ; Structure-Activity Relationship ; Vietnam
مستخلص: Low molecular weight secondary metabolites of marine fungi Aspergillus flocculosus , Aspergillus terreus and Penicillium sp. from Van Phong and Nha Trang Bays (Vietnam) were studied and a number of polyketides, bis-indole quinones and terpenoids were isolated. The structures of the isolated compounds were determined by 1D and 2D NMR and HR-ESI-MS techniques. Stereochemistry of some compounds was established based on ECD data. A chemical structure of asterriquinone F ( 6 ) was thoroughly described for the first time. Anthraquinone ( 13 ) was firstly obtained from a natural source. Neuroprotective influences of the isolated compounds against 6-OHDA, paraquat and rotenone toxicity were investigated. 4-Hydroxyscytalone ( 1 ), 4-hydroxy-6-dehydroxyscytalone ( 2 ) and demethylcitreoviranol ( 3 ) have shown significant increasing of paraquat- and rotenone-treated Neuro-2a cell viability and anti-ROS activity.
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معلومات مُعتمدة: 19-53-54002 Russian Foundation for Basic Research
فهرسة مساهمة: Keywords: Aspergillus flocculosus; Aspergillus terreus; Penicillium sp.; South China Sea; asterriquinones; marine-derived fungi; neuroprotective activity; polyketides; reactive oxygen species; secondary metabolites
المشرفين على المادة: 0 (Antiparkinson Agents)
0 (Neuroprotective Agents)
0 (Reactive Oxygen Species)
03L9OT429T (Rotenone)
PLG39H7695 (Paraquat)
SCR Organism: Aspergillus flocculosus; Aspergillus terreus
تواريخ الأحداث: Date Created: 20201203 Date Completed: 20210525 Latest Revision: 20210525
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7760690
DOI: 10.3390/md18120608
PMID: 33266016
قاعدة البيانات: MEDLINE
الوصف
تدمد:1660-3397
DOI:10.3390/md18120608