دورية أكاديمية
أعرض في EDS

Design of Nanosystems for the Delivery of Quorum Sensing Inhibitors: A Preliminary Study.

التفاصيل البيبلوغرافية
العنوان: Design of Nanosystems for the Delivery of Quorum Sensing Inhibitors: A Preliminary Study.
المؤلفون: Hallan SS; Department of Chemical and Pharmaceutical Sciences, University of Ferrara, I-44121 Ferrara, Italy.; Biofilms-Research Center for Biointerfaces, Faculty of Health and Society, Malmö University, SE-20506 Malmö, Sweden., Marchetti P; Department of Chemical and Pharmaceutical Sciences, University of Ferrara, I-44121 Ferrara, Italy., Bortolotti D; Department of Chemical and Pharmaceutical Sciences, University of Ferrara, I-44121 Ferrara, Italy., Sguizzato M; Department of Chemical and Pharmaceutical Sciences, University of Ferrara, I-44121 Ferrara, Italy.; Biotechnology Interuniversity Consortium (C.I.B.), Ferrara Section, University of Ferrara, I-44121 Ferrara, Italy., Esposito E; Department of Chemical and Pharmaceutical Sciences, University of Ferrara, I-44121 Ferrara, Italy.; Biotechnology Interuniversity Consortium (C.I.B.), Ferrara Section, University of Ferrara, I-44121 Ferrara, Italy., Mariani P; Department of Life and Environmental Sciences, Polytechnic University of Marche, I-60131 Ancona, Italy., Trapella C; Department of Chemical and Pharmaceutical Sciences, University of Ferrara, I-44121 Ferrara, Italy., Rizzo R; Department of Chemical and Pharmaceutical Sciences, University of Ferrara, I-44121 Ferrara, Italy., Cortesi R; Department of Chemical and Pharmaceutical Sciences, University of Ferrara, I-44121 Ferrara, Italy.; Biotechnology Interuniversity Consortium (C.I.B.), Ferrara Section, University of Ferrara, I-44121 Ferrara, Italy.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2020 Nov 30; Vol. 25 (23). Date of Electronic Publication: 2020 Nov 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Drug Delivery Systems* , Drug Design* , Quorum Sensing*, Anti-Bacterial Agents/*administration & dosage , Bacteria/*drug effects , Biofilms/*drug effects , Liposomes/*administration & dosage , Nanoparticles/*administration & dosage, Anti-Bacterial Agents/chemistry ; Liposomes/chemistry ; Nanoparticles/chemistry
مستخلص: Biofilm production is regulated by the Quorum Sensing system. Nowadays, Quorum Sensing represents an appealing target to design new compounds to increase antibiotics effects and avoid development of antibiotics multiresistance. In this research the use of liposomes to target two novel synthetic biofilm inhibitors is presented, focusing on a preformulation study to select a liposome composition for in vitro test. Five different liposome (LP) formulations, composed of phosphatidyl choline, cholesterol and charged surfactant (2:1:1, molar ratio) have been prepared by direct hydration and extrusion. As charged surfactants dicetyl phosphate didecyldimethylammonium chloride, di isobutyl phenoxy ethyl dimethyl benzyl ammonium chloride and stearylamine (SA) and have been used. Liposome charge, size and morphology were investigated by zeta potential, photon correlation spectroscopy, small angle x-ray spectroscopy and electron microscopy. LP-SA was selected for the loading of biofilm inhibitors and subjected to high performance liquid chromatography for entrapment capacity evaluation. LP-SA loaded inhibitors showed a higher diameter (223.6 nm) as compared to unloaded ones (205.7 nm) and a dose-dependent anti-biofilm effect mainly after 48 h of treatment, while free biofilm inhibitors loose activity. In conclusion, our data supported the use of liposomes as a strategy to enhance biofilm inhibitors effect.
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فهرسة مساهمة: Keywords: MTT test; QS inhibitors; biofilm; drug delivery; liposomes; nanotechnological systems
المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Liposomes)
تواريخ الأحداث: Date Created: 20201203 Date Completed: 20210408 Latest Revision: 20210408
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7730761
DOI: 10.3390/molecules25235655
PMID: 33266241
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules25235655