التفاصيل البيبلوغرافية
| العنوان: |
[Hypertrophic Cardiomyopathy as an Oligogenic Disease: Transcriptomic Arguments]. |
| المؤلفون: |
Baulina NM; National Medical Research Center for Cardiology, Moscow, 121552 Russia.; tasha.baulina@gmail.com., Kiselev IS; National Medical Research Center for Cardiology, Moscow, 121552 Russia., Chumakova OS; National Medical Research Center for Cardiology, Moscow, 121552 Russia., Favorova OO; National Medical Research Center for Cardiology, Moscow, 121552 Russia. |
| المصدر: |
Molekuliarnaia biologiia [Mol Biol (Mosk)] 2020 Nov-Dec; Vol. 54 (6), pp. 955-967. |
| نوع المنشور: |
Journal Article; Review |
| اللغة: |
Russian |
| بيانات الدورية: |
Publisher: Izdatelstvo Nauka Country of Publication: Russia (Federation) NLM ID: 0105454 Publication Model: Print Cited Medium: Print ISSN: 0026-8984 (Print) Linking ISSN: 00268984 NLM ISO Abbreviation: Mol Biol (Mosk) Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Moskva : Izdatelstvo Nauka |
| مواضيع طبية MeSH: |
Cardiomyopathy, Hypertrophic*/genetics , Cardiomyopathy, Hypertrophic*/pathology , MicroRNAs*/genetics , Transcriptome*, Animals ; Humans ; Mutation ; Sarcomeres/pathology |
| مستخلص: |
Hypertrophic cardiomyopathy (HCM) is the most common genetically determined heart pathology and is often accompanied by fatal complications. Today, the traditional view of the monogenic origin of HCM is being replaced by the idea of it as an oligogenic disease, the clinical phenotype of which is determined not only by mutations in the genes encoding sarcomere proteins in cardiomyocytes, but also by the contribution of other genes (other sarcomeric genes, non-sarcomeric protein-coding modifier genes, and regulatory non-coding RNA genes). Transcriptome analysis is an informative approach for elucidating the nature of HCM, which allows one to evaluate the expression of all genes, evaluate the effect of mutations in a gene on its transcript level, and reveal the mechanisms involved in the regulation of gene expression. This review presents an analysis of published data on the spectra of genes whose differential expression has been detected in the myocardium during the development of HCM in humans and model animals. Special attention is paid to the genes of non-coding regulatory RNAs: miRNAs and long non-coding RNAs, which may be involved in the pathogenesis of the disease. We analyzed studies devoted to the investigation of miRNA levels in the blood of HCM patients to explore the available diagnostic and prognostic biomarkers of the disease. The totality of the reviewed data, despite their relative scarcity, indicates the effectiveness of transcriptome profiling in studying the molecular mechanisms of HCM pathogenesis. |
| فهرسة مساهمة: |
Keywords: gene expression; hypertrophic cardiomyopathy; long non-coding RNA; miRNA; monogenic diseases; oligogenic diseases; regulatory non-coding RNA; transcriptome profiling |
| المشرفين على المادة: |
0 (MicroRNAs) |
| تواريخ الأحداث: |
Date Created: 20201204 Date Completed: 20201209 Latest Revision: 20201214 |
| رمز التحديث: |
20221213 |
| DOI: |
10.31857/S0026898420060026 |
| PMID: |
33276358 |
| قاعدة البيانات: |
MEDLINE |
