دورية أكاديمية
A novel streptonigrin type alkaloid from the Streptomyces flocculus CGMCC 4.1223 mutant Δ stnA/Q2 .
| العنوان: | A novel streptonigrin type alkaloid from the Streptomyces flocculus CGMCC 4.1223 mutant Δ stnA/Q2 . |
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| المؤلفون: | Wang X; State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory on Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China., Xu F; School of Medicine, Zhejiang University, Hangzhou, China., Huang T; State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory on Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China., Deng Z; State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory on Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China., Lin S; State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory on Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China. |
| المصدر: | Natural product research [Nat Prod Res] 2022 Jul; Vol. 36 (13), pp. 3337-3345. Date of Electronic Publication: 2020 Dec 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مواضيع طبية MeSH: | Alkaloids*/metabolism , Antineoplastic Agents*/chemistry , Streptomyces*/genetics , Streptomyces*/metabolism, Streptonigrin/chemistry ; Streptonigrin/metabolism |
| مستخلص: | Streptonigrin (STN) is a highly functionalized aminoquinone alkaloid with broad and potent antitumor activities. Previously, the biosynthetic gene cluster of STN was identified in Streptomyces flocculus CGMCC 4.1223, revealing an α/β-hydrolase (StnA) and a methyltransferase (StnQ2). In this work, a double mutant Δ stnA/Q2 was constructed by genetic manipulation and produced a novel derivative of STN, named as streptonigramide. Structure of streptonigramide was established by spectroscopic analyses. Its biosynthetic pathway has been proposed as well. |
| فهرسة مساهمة: | Keywords: Streptomyces flocculus; streptonigramide biosynthesis; streptonigrin |
| المشرفين على المادة: | 0 (Alkaloids) 0 (Antineoplastic Agents) 261Q3JB310 (Streptonigrin) |
| SCR Organism: | Streptomyces albus |
| تواريخ الأحداث: | Date Created: 20201207 Date Completed: 20220706 Latest Revision: 20220706 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1080/14786419.2020.1856840 |
| PMID: | 33280413 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1478-6427 |
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| DOI: | 10.1080/14786419.2020.1856840 |