دورية أكاديمية
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Therapeutic potential of natural products against atherosclerosis: Targeting on gut microbiota.

التفاصيل البيبلوغرافية
العنوان: Therapeutic potential of natural products against atherosclerosis: Targeting on gut microbiota.
المؤلفون: Zhao X; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin, China., Oduro PK; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China., Tong W; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China., Wang Y; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin, China., Gao X; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin, China. Electronic address: gaoxiumei@tjutcm.edu.cn., Wang Q; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin, China. Electronic address: wangqilong_00@tjutcm.edu.cn.
المصدر: Pharmacological research [Pharmacol Res] 2021 Jan; Vol. 163, pp. 105362. Date of Electronic Publication: 2020 Dec 05.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE
أسماء مطبوعة: Publication: Oct. 2015- : Amsterdam ; Elsevier
Original Publication: London ; San Diego : Academic Press, c1989-
مواضيع طبية MeSH: Atherosclerosis/*drug therapy , Biological Products/*therapeutic use , Gastrointestinal Microbiome/*drug effects, Animals ; Atherosclerosis/microbiology ; Humans
مستخلص: Gut microbiota (GM) has emerged as an essential and integral factor for maintaining human health and affecting pathological outcomes. Metagenomics and metabolomics characterization have furthered gut metagenome's understanding and unveiled that deviation of specific GM community members and GM-dependent metabolites imbalance orchestrate metabolic or cardiovascular diseases (CVDs). Restoring GM ecosystem with nutraceutical supplements keenly prebiotics and probiotics relatively decreases CVDs incidence and overall mortality. In Atherosclerosis, commensal and pathogenic gut microbes correlate with atherogenesis events. GM-dependent metabolites-trimethylamine N-oxide and short-chain fatty acids regulate atherosclerosis-related metabolic processes in opposite patterns to affect atherosclerosis outcomes. Therefore, GM might be a potential therapeutic target for atherosclerosis. In atherogenic animal models, natural products with cardioprotective properties could modulate the GM ecosystem by revitalizing healthier GM phylotypes and abrogating proatherogenic metabolites, paving future research paths for clinical therapeutics.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Atherosclerosis; Gut microbiota; Natural products; SCFAs; TMAO
المشرفين على المادة: 0 (Biological Products)
تواريخ الأحداث: Date Created: 20201207 Date Completed: 20211118 Latest Revision: 20211118
رمز التحديث: 20231215
DOI: 10.1016/j.phrs.2020.105362
PMID: 33285231
قاعدة البيانات: MEDLINE
الوصف
تدمد:1096-1186
DOI:10.1016/j.phrs.2020.105362