Ethanol consumption increases renal dysfunction and mortality in a mice model of sub-lethal sepsis.

التفاصيل البيبلوغرافية
العنوان:	Ethanol consumption increases renal dysfunction and mortality in a mice model of sub-lethal sepsis.
المؤلفون:	do Valle GT; Escola de Enfermagem de Ribeirão Preto (EERP), Universidade de São Paulo -USP, São Paulo, Brasil., Ricci ST; Escola de Enfermagem de Ribeirão Preto (EERP), Universidade de São Paulo -USP, São Paulo, Brasil., Silva AO; Departamento de Alimentos e Medicamentos, Universidade Federal de Alfenas (UNIFAL-MG), Minas Gerais, Brasil., Tirapelli CR; Escola de Enfermagem de Ribeirão Preto (EERP), Universidade de São Paulo -USP, São Paulo, Brasil., Ceron CS; Departamento de Alimentos e Medicamentos, Universidade Federal de Alfenas (UNIFAL-MG), Minas Gerais, Brasil.; Departamento de Ciências Biológicas, Universidade Federal de Ouro Preto (UFOP), Minas Gerais, Brasil.
المصدر:	Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2021 Jul; Vol. 99 (7), pp. 699-707. Date of Electronic Publication: 2020 Dec 08.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Canadian Science Publishing Country of Publication: Canada NLM ID: 0372712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1205-7541 (Electronic) Linking ISSN: 00084212 NLM ISO Abbreviation: Can J Physiol Pharmacol Subsets: MEDLINE
أسماء مطبوعة:	Publication: 2011- : Ottawa, ON : Canadian Science Publishing Original Publication: Ottawa, National Research Council of Canada.
مواضيع طبية MeSH:	Sepsis*, Animals ; Disease Models, Animal ; Hydrogen Peroxide ; Male ; Mice ; Oxidative Stress
مستخلص:	Chronic ethanol consumption and sepsis cause oxidative stress and renal dysfunction. This study aimed to examine whether chronic ethanol consumption sensitizes the mouse kidney to sub-lethal cecal ligation and puncture (SL-CLP) sepsis, leading to impairment of renal function by tissue oxidative and inflammatory damage. Male C57BL/6J mice were treated for 9 weeks with ethanol (20%, v / v ) before SL-CLP was induced. Systolic blood pressure (SBP), survival rate, creatinine plasma, oxidative stress, and inflammatory parameters, inducible nitric oxide synthase (iNOS), cytokines, and metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) levels were evaluated. Chronic ethanol consumption increased SBP, plasma creatinine, O 2 ^.- , H 2 O 2 , lipid peroxidation, catalase activity, Nox4, IL-6, and TNF-α levels, and MMP-9/TIMP-1 ratio. SL-CLP decreased SBP, increased creatinine, lipid peroxidation, IL-6, TNF-α, nitrate/nitrite (NOx), and iNOS levels, and MMP-2/TIMP-2 ratio, and decreased catalase activity. SL-CLP mice previously treated with ethanol showed a similar decrease in SBP but higher mortality and creatinine levels than SL-CLP alone. These responses were mediated by increased O 2 ^- , lipid peroxidation, IL-6, TNF-α, NOx, iNOS, MMP-2, and MMP-9 levels, and MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios. Our findings demonstrated that previous oxidative stress and inflammatory damage caused by ethanol consumption sensitizes the kidney to SL-CLP injury, resulting in impaired kidney function and sepsis prognosis.
فهرسة مساهمة:	Keywords: acute kidney injury; cecal ligation and puncture; consommation d’éthanol à long terme; dysfonctionnement des reins; ethanol chronic consumption; insuffisance rénale aiguë; kidney dysfunction; ligature et perforation du cæcum; metalloproteinases; mortalité par septicémie; métalloprotéinases; oxidative stress; sepsis mortality; stress oxydatif
المشرفين على المادة:	BBX060AN9V (Hydrogen Peroxide)
تواريخ الأحداث:	Date Created: 20201208 Date Completed: 20211203 Latest Revision: 20211214
رمز التحديث:	20221213
DOI:	10.1139/cjpp-2020-0564
PMID:	33290154
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	1205-7541
DOI:	10.1139/cjpp-2020-0564