دورية أكاديمية
Implementation of the asparaginase activity assessment technique for clinical use: experience of a Brazilian Center.
العنوان: | Implementation of the asparaginase activity assessment technique for clinical use: experience of a Brazilian Center. |
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المؤلفون: | Cecconello DK; Graduate Program in Child and Adolescent Health, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. daia_cecconello@hotmail.com.; Translational Pediatrics Laboratory, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil. daia_cecconello@hotmail.com.; Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil. daia_cecconello@hotmail.com., Rechenmacher C; Graduate Program in Child and Adolescent Health, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.; Translational Pediatrics Laboratory, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.; Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil., Werlang I; Translational Pediatrics Laboratory, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.; Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil., Zenatti PP; Centro Infantil Boldrini, Campinas, SP, Brazil., Yunes JA; Centro Infantil Boldrini, Campinas, SP, Brazil., Alegretti AP; Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil., Lanvers-Kaminsky C; University Children's Hospital of Münster, Münster, Germany., Daudt LE; Graduate Program in Child and Adolescent Health, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.; Translational Pediatrics Laboratory, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.; Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil., Michalowski MB; Graduate Program in Child and Adolescent Health, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.; Translational Pediatrics Laboratory, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.; Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil. |
المصدر: | Scientific reports [Sci Rep] 2020 Dec 08; Vol. 10 (1), pp. 21481. Date of Electronic Publication: 2020 Dec 08. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
مواضيع طبية MeSH: | Asparaginase/*analysis , Monitoring, Physiologic/*methods , Precursor Cell Lymphoblastic Leukemia-Lymphoma/*metabolism, Antineoplastic Agents/therapeutic use ; Asparaginase/metabolism ; Asparaginase/therapeutic use ; Brazil/epidemiology ; Child ; Child, Preschool ; Drug Hypersensitivity ; Female ; Humans ; Male ; Polyethylene Glycols/therapeutic use ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Treatment Outcome |
مستخلص: | Acute lymphoid leukemia is a childhood cancer that in high-income countries has event-free survival rates of 80% and global survival rates of 90%. In Brazil these rates are under 70%. This difference may be due to the implementation of supportive care, including the assessment of asparaginase (ASNase) activity. ASNase may cause hypersensitivity reactions and silent drug inactivation. For this reason, ASNase activity monitoring is an essential tool to ensure an effective treatment. Our aim was to implement an ASNase activity measurement technique at a hospital setting. samples from children who were given Escherichia coli-derived ASNase were collected. The results of the analyses conducted in our laboratory Hospital de Clínicas de Porto Alegre were compared to those of two institutions: Centro Infantil Boldrini and University of Munster. 262 samples were assessed. The results of the first analyses were compared with those obtained at Centro Infantil Boldrini and showed an ICC of 0.954. Thirty samples were sent to the University of Munster and presented an ICC was 0.960. Our results, when compared to those of national and international centers, showed an excellent agreement. The study was able to implement an ASNase activity test to monitor the treatment. |
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المشرفين على المادة: | 0 (Antineoplastic Agents) 3WJQ0SDW1A (Polyethylene Glycols) EC 3.5.1.1 (Asparaginase) |
تواريخ الأحداث: | Date Created: 20201209 Date Completed: 20210504 Latest Revision: 20210504 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC7722759 |
DOI: | 10.1038/s41598-020-78549-y |
PMID: | 33293625 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2045-2322 |
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DOI: | 10.1038/s41598-020-78549-y |