دورية أكاديمية
أعرض في EDS

Identification of human cytotoxic ILC3s.

التفاصيل البيبلوغرافية
العنوان: Identification of human cytotoxic ILC3s.
المؤلفون: Krabbendam L; Amsterdam UMC, Department of Experimental Immunology, University of Amsterdam, Amsterdam Infection & Immunity Institute (AI&II), Cancer Center Amsterdam, Amsterdam, The Netherlands., Heesters BA; Amsterdam UMC, Department of Experimental Immunology, University of Amsterdam, Amsterdam Infection & Immunity Institute (AI&II), Cancer Center Amsterdam, Amsterdam, The Netherlands., Kradolfer CMA; Amsterdam UMC, Department of Experimental Immunology, University of Amsterdam, Amsterdam Infection & Immunity Institute (AI&II), Cancer Center Amsterdam, Amsterdam, The Netherlands., Spits H; Amsterdam UMC, Department of Experimental Immunology, University of Amsterdam, Amsterdam Infection & Immunity Institute (AI&II), Cancer Center Amsterdam, Amsterdam, The Netherlands., Bernink JH; Amsterdam UMC, Department of Experimental Immunology, University of Amsterdam, Amsterdam Infection & Immunity Institute (AI&II), Cancer Center Amsterdam, Amsterdam, The Netherlands.
المصدر: European journal of immunology [Eur J Immunol] 2021 Apr; Vol. 51 (4), pp. 811-823. Date of Electronic Publication: 2021 Jan 27.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 1273201 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4141 (Electronic) Linking ISSN: 00142980 NLM ISO Abbreviation: Eur J Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2005->: Weinheim : Wiley-VCH
Original Publication: Weinheim, Verlag Chemie GmbH.
مواضيع طبية MeSH: Cell Differentiation/*immunology , Gene Expression Profiling/*methods , Gene Expression Regulation/*immunology , Killer Cells, Natural/*immunology , Lymphocytes/*immunology, Animals ; Cell Differentiation/genetics ; Cell Line ; Cytotoxicity, Immunologic/genetics ; Cytotoxicity, Immunologic/immunology ; Gene Expression Regulation/drug effects ; Humans ; Immunity, Innate/immunology ; Interleukin-15/pharmacology ; Interleukin-7 Receptor alpha Subunit/genetics ; Interleukin-7 Receptor alpha Subunit/immunology ; Killer Cells, Natural/cytology ; Killer Cells, Natural/metabolism ; Lymphocytes/cytology ; Lymphocytes/metabolism ; Mice ; NK Cell Lectin-Like Receptor Subfamily D/genetics ; NK Cell Lectin-Like Receptor Subfamily D/immunology ; Nuclear Receptor Subfamily 1, Group F, Member 3/genetics ; Nuclear Receptor Subfamily 1, Group F, Member 3/immunology
مستخلص: Human ILCs are classically categorized into five subsets; cytotoxic CD127 - CD94 + NK cells and non-cytotoxic CD127 + CD94 - , ILC1s, ILC2s, ILC3s, and LTi cells. Here, we identify a previously unrecognized subset within the CD127 + ILC population, characterized by the expression of the cytotoxic marker CD94. These CD94 + ILCs resemble conventional ILC3s in terms of phenotype, transcriptome, and cytokine production, but are highly cytotoxic. IL-15 was unable to induce differentiation of CD94 + ILCs toward mature NK cells. Instead, CD94 + ILCs retained RORγt, CD127 and CD200R1 expression and produced IL-22 in response to IL-15. Culturing non-cytotoxic ILC3s with IL-12 induced upregulation of CD94 and cytotoxic activity, effects that were not observed with IL-15 stimulation. Thus, human helper ILCs can acquire a cytotoxic program without differentiating into NK cells.
(© 2020 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.)
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فهرسة مساهمة: Keywords: IL-12; IL-15; NK cells; innate lymphoid cells; tonsil
المشرفين على المادة: 0 (Interleukin-15)
0 (Interleukin-7 Receptor alpha Subunit)
0 (NK Cell Lectin-Like Receptor Subfamily D)
0 (Nuclear Receptor Subfamily 1, Group F, Member 3)
تواريخ الأحداث: Date Created: 20201210 Date Completed: 20210920 Latest Revision: 20210920
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8248192
DOI: 10.1002/eji.202048696
PMID: 33300130
قاعدة البيانات: MEDLINE
الوصف
تدمد:1521-4141
DOI:10.1002/eji.202048696