دورية أكاديمية
An Assessment of Research Priorities to Dampen the Pendulum Swing of Burn Resuscitation.
| العنوان: | An Assessment of Research Priorities to Dampen the Pendulum Swing of Burn Resuscitation. |
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| المؤلفون: | Burmeister DM; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland.; United States Army Institute of Surgical Research, JBSA Fort Sam Houston, Texas., Smith SL; The Warden Burn Center, Orlando Regional Medical Center, Orlando, Florida., Muthumalaiappan K; Department of Surgery, Loyola University Chicago, Maywood, Illinois., Hill DM; Firefighters' Burn Center, Regional One Health, Memphis, Tennessee., Moffatt LT; Firefighters' Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, District of Columbia.; The Burn Center, MedStar Washington Hospital Center; Department of Surgery, Georgetown University School of Medicine, Washington, District of Columbia., Carlson DL; Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas., Kubasiak JC; Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts., Chung KK; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland., Wade CE; Center for Translational Injury Research, and Department of Surgery, McGovern School of Medicine and The John S. Dunn Burn Center, Memorial Herman Hospital, Houston, Texas., Cancio LC; United States Army Institute of Surgical Research, JBSA Fort Sam Houston, Texas., Shupp JW; Firefighters' Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, District of Columbia.; The Burn Center, MedStar Washington Hospital Center; Department of Surgery, Georgetown University School of Medicine, Washington, District of Columbia. |
| المصدر: | Journal of burn care & research : official publication of the American Burn Association [J Burn Care Res] 2021 Mar 04; Vol. 42 (2), pp. 113-125. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101262774 Publication Model: Print Cited Medium: Internet ISSN: 1559-0488 (Electronic) Linking ISSN: 1559047X NLM ISO Abbreviation: J Burn Care Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2018- : Oxford : Oxford University Press Original Publication: Hagerstown, MD : Lippincott Williams & Wilkins, c2006- |
| مواضيع طبية MeSH: | Burns/*therapy , Critical Care/*standards , Evidence-Based Medicine/*standards , Resuscitation/*standards, Humans ; Multiple Organ Failure/prevention & control ; Research Design/standards ; Shock, Traumatic/prevention & control ; Societies, Medical/standards |
| مستخلص: | On June 17 to 18, 2019, the American Burn Association, in conjunction with Underwriters Laboratories, convened a group of experts on burn resuscitation in Washington, DC. The goal of the meeting was to identify and discuss novel research and strategies to optimize the process of burn resuscitation. Patients who sustain a large thermal injury (involving >20% of the total body surface area [TBSA]) face a sequence of challenges, beginning with burn shock. Over the last century, research has helped elucidate much of the underlying pathophysiology of burn shock, which places multiple organ systems at risk of damage or dysfunction. These studies advanced the understanding of the need for fluids for resuscitation. The resultant practice of judicious and timely infusion of crystalloids has improved mortality after major thermal injury. However, much remains unclear about how to further improve and customize resuscitation practice to limit the morbidities associated with edema and volume overload. Herein, we review the history and pathophysiology of shock following thermal injury, and propose some of the priorities for resuscitation research. Recommendations include: studying the utility of alternative endpoints to resuscitation, reexamining plasma as a primary or adjunctive resuscitation fluid, and applying information about inflammation and endotheliopathy to target the underlying causes of burn shock. Undoubtedly, these future research efforts will require a concerted effort from the burn and research communities. (Published by Oxford University Press on behalf of the American Burn Association 2020.) |
| تواريخ الأحداث: | Date Created: 20201211 Date Completed: 20220118 Latest Revision: 20220118 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1093/jbcr/iraa214 |
| PMID: | 33306095 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1559-0488 |
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| DOI: | 10.1093/jbcr/iraa214 |