دورية أكاديمية
Treatment of women with heavy menstrual bleeding: Results of a prospective cohort study alongside a randomised controlled trial.
| العنوان: | Treatment of women with heavy menstrual bleeding: Results of a prospective cohort study alongside a randomised controlled trial. |
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| المؤلفون: | Beelen P; Department of Obstetrics and Gynaecology, Máxima MC, Veldhoven, the Netherlands; Department of General Practice, University of Maastricht, Maastricht, the Netherlands. Electronic address: pleun.beelen@gmail.com., van der Velde MGAM; Department of Obstetrics and Gynaecology, Máxima MC, Veldhoven, the Netherlands., Herman MC; Department of Obstetrics and Gynaecology, Jeroen Bosch Hospital's Hertogenbosch, the Netherlands., Geomini PM; Department of Obstetrics and Gynaecology, Máxima MC, Veldhoven, the Netherlands., van den Brink MJ; Department of General Practice and Elderly Care Medicine, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands., Duijnhoven RG; Department of Obstetrics and Gynaecology, Academic Medical Centre, Amsterdam, the Netherlands., Bongers MY; Department of Obstetrics and Gynaecology, Máxima MC, Veldhoven, the Netherlands; Maastricht University, Grow Research School of Oncology and Developmental Biology, Maastricht, the Netherlands. |
| المصدر: | European journal of obstetrics, gynecology, and reproductive biology [Eur J Obstet Gynecol Reprod Biol] 2021 Feb; Vol. 257, pp. 1-5. Date of Electronic Publication: 2020 Dec 01. |
| نوع المنشور: | Journal Article; Multicenter Study; Observational Study; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 0375672 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7654 (Electronic) Linking ISSN: 03012115 NLM ISO Abbreviation: Eur J Obstet Gynecol Reprod Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Scientific Publishers Original Publication: Amsterdam, Excerpta Medica. |
| مواضيع طبية MeSH: | Contraceptive Agents, Female* , Endometrial Ablation Techniques* , Intrauterine Devices, Medicated* , Menorrhagia*/drug therapy , Menorrhagia*/surgery, Adult ; Female ; Humans ; Levonorgestrel ; Netherlands |
| مستخلص: | Objective: The objective of this study was to compare the reintervention rate of women who opted for treatment with the levonorgestrel-releasing intrauterine system (LNG-IUS) to women who opted for endometrial ablation. Furthermore, the difference in reintervention rate between women in this observational cohort and women who were randomised was compared, with the hypothesis that women who actively decide on treatment have lower reintervention rates compared to women in a RCT. Study Design: An observational cohort study alongside a multicentre randomised controlled trial (RCT) was conducted between April 2012 and January 2016, with a follow-up time of 24 months, in 26 hospitals and nearby general practices in the Netherlands. Women suffering from heavy menstrual bleeding, aged 34 years and older, without intracavitary pathology and without a future fertility desire, were eligible for this trial. Women who declined randomisation were asked to participate in the observational cohort. The outcome measure was reintervention rate at 24 months of follow-up. Results: 276 women were followed in the observational cohort of which 87 women preferred an initial treatment with LNG-IUS and 189 women preferred an initial treatment with endometrial ablation. At 24 months of follow-up women in the LNG-IUS-group were more likely to receive a reintervention compared to the women in the ablation group, 28/81 (35 %) versus 25/178 (14 %) (aRR 2.42, CI 1.47-3.98, p-value 0.001). No differences in reintervention rates were found between women in the observational cohort and women in the RCT. Conclusions: Women who receive an LNG-IUS are more likely to undergo an additional intervention compared to women who receive endometrial ablation. Reintervention rates of women in the cohort and RCT population were comparable. The results of this study endorse the findings of the RCT and will contribute to shared decision making in women with heavy menstrual bleeding. Competing Interests: Declaration of Competing Interest The authors report no declarations of interest. (Copyright © 2020 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Endometrial ablation; Heavy menstrual bleeding; Levonorgestrel intrauterine system; Reintervention |
| المشرفين على المادة: | 0 (Contraceptive Agents, Female) 5W7SIA7YZW (Levonorgestrel) |
| تواريخ الأحداث: | Date Created: 20201214 Date Completed: 20210514 Latest Revision: 20210514 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.ejogrb.2020.11.071 |
| PMID: | 33309849 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1872-7654 |
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| DOI: | 10.1016/j.ejogrb.2020.11.071 |