دورية أكاديمية
أعرض في EDS

Germinal Center and Extrafollicular B Cell Responses in Vaccination, Immunity, and Autoimmunity.

التفاصيل البيبلوغرافية
العنوان: Germinal Center and Extrafollicular B Cell Responses in Vaccination, Immunity, and Autoimmunity.
المؤلفون: Elsner RA; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15216, USA., Shlomchik MJ; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15216, USA. Electronic address: mshlomch@pitt.edu.
المصدر: Immunity [Immunity] 2020 Dec 15; Vol. 53 (6), pp. 1136-1150.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE
أسماء مطبوعة: Publication: Cambridge, MA : Cell Press
Original Publication: Cambridge, Mass. : Cell Press, c1994-
مواضيع طبية MeSH: B-Lymphocyte Subsets/*immunology , B-Lymphocytes/*immunology , Germinal Center/*immunology , Immunity/*immunology, Animals ; Autoimmune Diseases/immunology ; Humans ; Immunoglobulin Class Switching ; Infections/etiology ; Infections/immunology ; Lymphocyte Activation ; Plasma Cells/immunology ; Vaccines/immunology
مستخلص: Activated B cells participate in either extrafollicular (EF) or germinal center (GC) responses. Canonical responses are composed of a short wave of plasmablasts (PBs) arising from EF sites, followed by GC producing somatically mutated memory B cells (MBC) and long-lived plasma cells. However, somatic hypermutation (SHM) and affinity maturation can take place at both sites, and a substantial fraction of MBC are produced prior to GC formation. Infection responses range from GC responses that persist for months to persistent EF responses with dominant suppression of GCs. Here, we review the current understanding of the functional output of EF and GC responses and the molecular switches promoting them. We discuss the signals that regulate the magnitude and duration of these responses, and outline gaps in knowledge and important areas of inquiry. Understanding such molecular switches will be critical for vaccine development, interpretation of vaccine efficacy and the treatment for autoimmune diseases.
Competing Interests: Declaration of Interests The authors declare no competing interests.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: T32 AI060525 United States AI NIAID NIH HHS; R37 AI118841 United States AI NIAID NIH HHS; R01 AI105018 United States AI NIAID NIH HHS; T32 AI089443 United States AI NIAID NIH HHS; R01 AI043603 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (Vaccines)
تواريخ الأحداث: Date Created: 20201216 Date Completed: 20210521 Latest Revision: 20211216
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7748291
DOI: 10.1016/j.immuni.2020.11.006
PMID: 33326765
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-4180
DOI:10.1016/j.immuni.2020.11.006