دورية أكاديمية
أعرض في EDS

Improvement in Cardiovascular Autonomic Neuropathy After High-Dose Vitamin D Supplementation in Patients With Type 1 Diabetes.

التفاصيل البيبلوغرافية
العنوان: Improvement in Cardiovascular Autonomic Neuropathy After High-Dose Vitamin D Supplementation in Patients With Type 1 Diabetes.
المؤلفون: Silva LSD; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Queiroz NNM; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Melo FTC; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Abrahão Neto JF; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Janaú LC; Department of Medicine, State University of Pará, Belém, Brazil., de Souza Neto NJK; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Lemos MN; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Oliveira MCNI; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Alcântara AL; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Moraes LV; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., da Silva WM; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Souza ÍJA; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Said NM; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Lemos GN; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Felício KM; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Dos Santos MC; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Motta ARB; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Dos Reis MSO; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Lobato IJC; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Figueiredo PBB; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Souza ACCB; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Piani PPF; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Felício JS; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil.
المصدر: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2020 Nov 19; Vol. 11, pp. 605681. Date of Electronic Publication: 2020 Nov 19 (Print Publication: 2020).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مواضيع طبية MeSH: Dietary Supplements*, Autonomic Nervous System Diseases/*drug therapy , Cardiovascular Diseases/*drug therapy , Diabetes Mellitus, Type 1/*complications , Diabetic Neuropathies/*drug therapy , Vitamin D/*administration & dosage, Adolescent ; Adult ; Autonomic Nervous System Diseases/etiology ; Autonomic Nervous System Diseases/pathology ; Blood Glucose/analysis ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/pathology ; Child ; Diabetic Neuropathies/etiology ; Diabetic Neuropathies/pathology ; Female ; Heart Rate ; Humans ; Male ; Middle Aged ; Pilot Projects ; Prospective Studies ; Vitamins/administration & dosage ; Young Adult
مستخلص: Background: Cardiovascular autonomic neuropathy (CAN) is associated with diabetes mellitus , increasing morbidity and mortality. Some cross-sectional studies associated CAN with low 25-hydroxyvitamin D levels. The aim of our study was to evaluate the effect of high-dose vitamin D (VD) supplementation on CAN in Type 1 Diabetes Mellitus (T1DM) patients.
Methods: We performed a prospective study with 23 patients diagnosed with T1DM and CAN. Subjects with VD levels <30 ng/ml received 10,000 IU/day; the ones with VD levels between 30-60 ng/ml were given 4,000 IU/day for 12 weeks.
Results: There was an improvement in CAN parameters related to resting heart rate variability, such as time domain parameters [Maximum RR interval (0.77 ± 0.11 vs 0.94 ± 0.51 s, p <0.05), Mean length of regular RR intervals (0.71 ± 0.10 vs 0.76 ± 0.09 s, p <0.05) and Standard deviation of all NN intervals (0.02 ± 0.01 vs 0.03 ± 0.02 s; p <0.01)] and frequency domain parameters [Low Frequency (1.9 ± 0.5 vs 2.5 ± 0.9 s, p < 0.001), Total Power (2.5 ± 0.4 vs 2.8 ± 0.6 s, p <0.05)]. In addition, there was a correlation between absolute VD level variation and posttreatment High Frequency (%), as well as among percent variation in VD level and end-of-study Low Frequency/High Frequency ratio (r=0.6, p<0.01; r= -0.5, p<0.05, respectively).
Conclusion: Our pilot study is the first to suggest a strong association between high-dose vitamin D supplementation and improved cardiovascular autonomic neuropathy in T1DM patients. It occurred without any variation in HbA1C, blood pressure levels, lipids, and insulin dose.
Clinical Trial Registration: http://www.isrctn.com/ISRCTN32601947, identifier ISRCTN32601947.
(Copyright © 2020 Silva, de Queiroz, de Melo, Abrahão Neto, Janaú, de Souza Neto, de Lemos, de Oliveira, de Alcântara, de Moraes, da Silva, de Souza, Said, de Lemos, Felício, Santos, Motta, dos Reis, Lobato, de Figueiredo, de Souza, Piani and Felício.)
References: Handb Clin Neurol. 2014;126:63-79. (PMID: 25410215)
Endocr Pract. 2015 Feb;21(2):174-81. (PMID: 25297669)
Ann Intern Med. 2009 May 5;150(9):604-12. (PMID: 19414839)
Front Endocrinol (Lausanne). 2017 Aug 14;8:199. (PMID: 28855892)
Curr Diabetes Rev. 2018;14(4):395-403. (PMID: 28618984)
Medicine (Baltimore). 2020 Jul 31;99(31):e20871. (PMID: 32756079)
Diabetes. 2006 Feb;55(2):341-8. (PMID: 16443766)
Metabolism. 2018 Feb;79:1-9. (PMID: 29113812)
Semin Neurol. 2019 Oct;39(5):560-569. (PMID: 31639839)
Diabetes Metab Res Rev. 2011 Oct;27(7):639-53. (PMID: 21695768)
Front Endocrinol (Lausanne). 2016 Dec 12;7:149. (PMID: 28018288)
Exp Clin Cardiol. 2010 Spring;15(1):e5-9. (PMID: 20664771)
Nutrients. 2020 Aug 20;12(9):. (PMID: 32825324)
Diabetes Metab Res Rev. 2020 Jun 7;:e3361. (PMID: 32506740)
Neurosignals. 2019;27(1):40-49. (PMID: 31769259)
Int J Endocrinol. 2013;2013:148673. (PMID: 23573085)
Diabetes Metab Syndr. 2013 Jul-Sep;7(3):148-53. (PMID: 23953180)
Curr Diabetes Rev. 2020 Jul 29;:. (PMID: 32729423)
Ann Intern Med. 1980 Feb;92(2 Pt 2):308-11. (PMID: 7356219)
Front Neurosci. 2018 Aug 27;12:591. (PMID: 30210276)
J Diabetes Res. 2017;2017:6719239. (PMID: 28373993)
J Med Syst. 2012 Jun;36(3):1935-41. (PMID: 21271353)
Diab Vasc Dis Res. 2015 Sep;12(5):342-51. (PMID: 26150192)
Neurol Sci. 2015 Jul;36(7):1121-6. (PMID: 25851730)
Curr Diab Rep. 2017 Oct 23;17(12):125. (PMID: 29063207)
Diabetes Care. 2020 Jan;43(Suppl 1):S7-S13. (PMID: 31862744)
Curr Diab Rep. 2018 Oct 25;18(12):137. (PMID: 30361834)
BMC Cardiovasc Disord. 2017 Jan 19;17(1):34. (PMID: 28103812)
Diabetes Res Clin Pract. 2018 Sep;143:159-169. (PMID: 30006307)
N Engl J Med. 2016 Nov 10;375(19):1817-1820. (PMID: 27959647)
J Electrocardiol. 1992 Apr;25(2):79-88. (PMID: 1522401)
N Engl J Med. 2003 Jan 30;348(5):383-93. (PMID: 12556541)
Int J Cardiol. 2014 Mar 15;172(2):506-8. (PMID: 24502876)
Diabetologia. 1999 Nov;42(11):1308-13. (PMID: 10550414)
World J Diabetes. 2014 Feb 15;5(1):17-39. (PMID: 24567799)
Diabet Med. 2017 Mar;34(3):364-371. (PMID: 27696502)
Am J Cardiol. 2007 Sep 1;100(5):890-3. (PMID: 17719340)
Circulation. 2009 Jun 9;119(22):2886-93. (PMID: 19470886)
Arq Bras Endocrinol Metabol. 2008 Mar;52(2):166-80. (PMID: 18438527)
Int J Mol Sci. 2018 Jul 31;19(8):. (PMID: 30065237)
Diabetes Care. 2003 May;26(5):1553-79. (PMID: 12716821)
Neuropsychobiology. 2020;79(3):179-185. (PMID: 31812959)
Clin Nutr. 2020 Oct;39(10):2970-2974. (PMID: 32089370)
Lancet. 1998 Dec 19-26;352(9145):1978-81. (PMID: 9872248)
Biomed Eng Online. 2009 Jan 29;8:3. (PMID: 19178728)
J Diabetes Complications. 2017 Sep;31(9):1389-1393. (PMID: 28728915)
J Auton Nerv Syst. 1998 Apr 30;69(2-3):164-72. (PMID: 9696273)
فهرسة مساهمة: Keywords: autonomic nervous system; cardiovascular autonomic neuropathy; diabetes mellitus type 1; heart rate; vitamin D
سلسلة جزيئية: ISRCTN ISRCTN32601947
المشرفين على المادة: 0 (Blood Glucose)
0 (Vitamins)
1406-16-2 (Vitamin D)
تواريخ الأحداث: Date Created: 20201217 Date Completed: 20210603 Latest Revision: 20210603
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7711089
DOI: 10.3389/fendo.2020.605681
PMID: 33329405
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-2392
DOI:10.3389/fendo.2020.605681