COVID-19 Test Strategy to Guide Quarantine Interval in University Student.
| العنوان: | COVID-19 Test Strategy to Guide Quarantine Interval in University Student. |
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| المؤلفون: | Kolesar JM, Gayheart T, Poston L, Monday E, Forster D, Belcher E, Jaiswal R, Turner JK, Arnett DK, Durbin EB, Monroe J, Romanelli F, Arnold SM, Jennings CD, Weiss H, DiPaola R |
| المصدر: | MedRxiv : the preprint server for health sciences [medRxiv] 2020 Dec 11. Date of Electronic Publication: 2020 Dec 11. |
| نوع المنشور: | Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
| مستخلص: | Background: Following COVID-19 exposure, the CDC recommends a 10-14 day quarantine for asymptomatic individuals and more recently a 7 day quarantine with a negative PCR test. We performed a university-based prospective student cohort study to determine if early PCR negativity predicts day 14 negativity. Methods: We enrolled 101 asymptomatic, quarantining, students, performed nasopharyngeal swabs for viral testing on days 3 or 4, 5, 7, 10 and 14 and determined the proportion of concordant negative results for each day versus day 14 with a two-sided 95% exact binomial confidence interval. Results: Overall, 14 of 90 (16%, 95% CI: 9% - 25%) tested positive while in quarantine, with 7 initial positive tests on day 3 or 4, 5 on day 5, 2 on day 7, and none on day 10 or 14. Rates of concordant negative test results are: day 5 vs. day 14 = 45/50 (90%, 95% CI: 78% - 97%); day 7 vs. day 14 = 47/52 (90%, 95% CI: 79% - 97%); day 10 vs. day 14 = 48/53 (91%, 95% CI:79% - 97%), with no evidence of different negative rates between earlier days and day 14 by McNemar's test, p > 0.05. Conclusions: The 16% positive rate supports the ongoing need to quarantine close contacts of COVID-19 cases, but this prospective study provides the first direct evidence that exposed asymptomatic students ages 18-44 years in a university setting are at low risk if released from quarantine at 7 days if they test negative PCR test prior to release. |
| معلومات مُعتمدة: | P30 CA177558 United States CA NCI NIH HHS |
| تواريخ الأحداث: | Date Created: 20201217 Latest Revision: 20221007 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC7743099 |
| DOI: | 10.1101/2020.12.09.20246785 |
| PMID: | 33330888 |
| قاعدة البيانات: | MEDLINE |
| DOI: | 10.1101/2020.12.09.20246785 |
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