دورية أكاديمية
Association of dietary and gut microbiota-related metabolites with calcific aortic stenosis.
| العنوان: | Association of dietary and gut microbiota-related metabolites with calcific aortic stenosis. |
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| المؤلفون: | Kocyigit D; Faculty of Medicine, Department of Cardiology, Hacettepe University, Ankara, Turkey., Tokgozoglu L; Faculty of Medicine, Department of Cardiology, Hacettepe University, Ankara, Turkey., Gurses KM; Faculty of Medicine, Department of Basic Medical Sciences, Adnan Menderes University, Aydin, Turkey., Stahlman M; Department of Molecular and Clinical Medicine, University of Gothenburg Institute of Medicine, Göteborg, Sweden., Boren J; Department of Molecular and Clinical Medicine, University of Gothenburg Institute of Medicine, Göteborg, Sweden., Soyal MFT; Department of Cardiovascular Surgery, Medicana International Ankara Hospital, Ankara, Turkey., Canpınar H; Department of Basic Oncology, Institute of Oncology, Hacettepe University, Ankara, Turkey., Guc D; Department of Basic Oncology, Institute of Oncology, Hacettepe University, Ankara, Turkey., Saglam Ayhan A; Faculty of Medicine, Department of Medical Pathology, Hacettepe University, Ankara, Turkey., Hazirolan T; Faculty of Medicine, Department of Radiology, Hacettepe University, Ankara, Turkey., Ozer N; Faculty of Medicine, Department of Cardiology, Hacettepe University, Ankara, Turkey. |
| المصدر: | Acta cardiologica [Acta Cardiol] 2021 Jul; Vol. 76 (5), pp. 544-552. Date of Electronic Publication: 2020 Dec 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 0370570 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1784-973X (Electronic) Linking ISSN: 00015385 NLM ISO Abbreviation: Acta Cardiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : London : Taylor & Francis Original Publication: Bruxelles : Acta Medica Belgica |
| مواضيع طبية MeSH: | Aortic Valve Stenosis* , Gastrointestinal Microbiome*, Aortic Valve/diagnostic imaging ; Betaine ; Choline ; Humans |
| مستخلص: | Background: Histopathological changes in calcific aortic stenosis (CAS) resemble changes in coronary atherosclerosis. Concerning recent evidence on dietary and gut microbiota-related metabolites representing players in atherosclerosis, we aimed to investigate the link between dietary and gut microbiota-derived metabolites and CAS. Methods: We consecutively recruited eligible subjects with moderate-severe CAS ( n = 60), aortic sclerosis (ASc) ( n = 49) and age and gender-matched control subjects ( n = 48) in May 2016-December 2016. Plasma dietary and gut microbiota-related metabolite levels, namely choline, betaine, and trimethylamine N-oxide (TMAO), were measured using ultra-performance liquid chromatography-tandem mass spectroscopy method. Histopathological examinations were performed in patients that underwent aortic valve surgery. Results: Prevalence of traditional cardiovascular risk factors or co-morbidities did not differ among groups (all p > 0.05). CAS patients had higher plasma choline levels compared to both control ( p < 0.001) and ASc ( p = 0.006). Plasma betaine and TMAO levels were similar (both p > 0.05). Compared to the lowest quartile choline levels (<11.15 μM), patients with the highest quartile choline levels (≥14.98 μM) had higher aortic valvular ( p < 0.001) and mitral annular ( p = 0.013) calcification scores. Plasma choline levels were independently associated with aortic peak flow velocity (B ± SE:0.165 ± 0.060, p = 0.009). Choline levels were elevated in subjects who had aortic valves with denser lymphocyte infiltration ( p < 0.001), neovascularization ( p = 0.011), osseous metaplasia ( p = 0.004), more severe tissue remodelling ( p = 0.002) and calcification ( p = 0.002). Conclusion: We found a significant association between choline levels and CAS presence and severity depicted on imaging modalities and histopathological examinations. Our study may open new horizons for prevention of CAS. |
| فهرسة مساهمة: | Keywords: Calcific aortic stenosis; betaine; choline; trimethylamine N-oxide |
| المشرفين على المادة: | 3SCV180C9W (Betaine) N91BDP6H0X (Choline) |
| تواريخ الأحداث: | Date Created: 20201218 Date Completed: 20211125 Latest Revision: 20220424 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1080/00015385.2020.1853968 |
| PMID: | 33334254 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1784-973X |
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| DOI: | 10.1080/00015385.2020.1853968 |