دورية أكاديمية
Does Gut Microbiota Influence the Course of Parkinson's Disease? A 3-Year Prospective Exploratory Study in de novo Patients.
| العنوان: | Does Gut Microbiota Influence the Course of Parkinson's Disease? A 3-Year Prospective Exploratory Study in de novo Patients. |
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| المؤلفون: | Cilia R; Fondazione IRCCS Istituto Neurologico Carlo Besta, Parkinson and Movement Disorders Unit, Milan, Italy., Piatti M; Department of Neurology, Milan Center for Neuroscience, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy., Cereda E; Clinical Nutrition and Dietetics Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Bolliri C; Parkinson Institute, ASST Gaetano Pini-CTO, Milan, Italy., Caronni S; Parkinson Institute, ASST Gaetano Pini-CTO, Milan, Italy., Ferri V; Parkinson Institute, ASST Gaetano Pini-CTO, Milan, Italy., Cassani E; Parkinson Institute, ASST Gaetano Pini-CTO, Milan, Italy., Bonvegna S; Fondazione IRCCS Istituto Neurologico Carlo Besta, Parkinson and Movement Disorders Unit, Milan, Italy., Ferrarese C; Department of Neurology, Milan Center for Neuroscience, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy., Zecchinelli AL; Parkinson Institute, ASST Gaetano Pini-CTO, Milan, Italy., Barichella M; Parkinson Institute, ASST Gaetano Pini-CTO, Milan, Italy., Pezzoli G; Parkinson Institute, ASST Gaetano Pini-CTO, Milan, Italy.; Fondazione Grigioni per il Morbo di Parkinson, Milan, Italy. |
| المصدر: | Journal of Parkinson's disease [J Parkinsons Dis] 2021; Vol. 11 (1), pp. 159-170. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: IOS Press Country of Publication: Netherlands NLM ID: 101567362 Publication Model: Print Cited Medium: Internet ISSN: 1877-718X (Electronic) Linking ISSN: 18777171 NLM ISO Abbreviation: J Parkinsons Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : IOS Press |
| مواضيع طبية MeSH: | Disease Progression* , Gastrointestinal Microbiome*, Cognitive Dysfunction/*physiopathology , Dysbiosis/*microbiology , Executive Function/*physiology , Parkinson Disease/*microbiology , Parkinson Disease/*physiopathology, Aged ; Cognitive Dysfunction/etiology ; Dysbiosis/diagnosis ; Feces ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Parkinson Disease/diagnosis ; Prognosis ; Proof of Concept Study ; Prospective Studies ; RNA, Ribosomal, 16S ; Sequence Analysis, RNA |
| مستخلص: | Background: Although abnormalities in gut microbiota are hypothesized to influence the pathogenesis and clinical phenotype of Parkinson's disease (PD), prospective studies on de novo patients are lacking. Objective: To preliminarily investigate whether gut microbiota in early untreated PD may predict motor and non-motor features progression over a 3-year period. Methods: 16S ribosomal RNA gene amplicons were sequenced on fecal samples of 39 de novo PD patients. Multiple confounders were taken into account, including dietary habits. Motor and non-motor symptoms were assessed using validated scales at baseline and followed-up yearly for 3 years. At last follow-up, a detailed neuropsychological assessment was additionally performed. A general linear model for repeated measurements- adjusted by dopaminergic therapy at follow-up- was used to investigate the relationship between bacterial taxa abundance at baseline (stratified by the median of distribution at baseline) and outcome variables. Results: Twenty-five patients were included (11 refused, 2 lost at follow-up, 1 died). Lower abundance of Roseburia (Firmicutes phylum) at baseline was associated with worse evolution of motor, non-motor and cognitive functions at 3-year follow-up. Similarly, lower abundance of Ruminococcaceae and Actinobacteria at baseline was associated with faster worsening of global cognitive functions. At follow-up, frontal lobe functions were the features most robustly associated with baseline microbial abnormalities. Conclusion: In the present exploratory study on de novo PD, we found an association between abnormal distribution of specific bacterial taxa and the progression of motor and non-motor features over a 3-year period. This proof-of-principle study supports the design of a larger observational study aiming to determine whether these differences survive multiple-comparison correction and define microbiota-specific subgroups suitable for therapeutic targeting. |
| فهرسة مساهمة: | Keywords: Parkinson’s disease; de novo; gut microbiota; prognosis; prospective study |
| المشرفين على المادة: | 0 (RNA, Ribosomal, 16S) |
| تواريخ الأحداث: | Date Created: 20201218 Date Completed: 20211112 Latest Revision: 20211112 |
| رمز التحديث: | 20240628 |
| DOI: | 10.3233/JPD-202297 |
| PMID: | 33337387 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1877-718X |
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| DOI: | 10.3233/JPD-202297 |